This experiment was conducted to investigate the effects of fish oil supplementation on production performance, inflammatory parameters and hypothalamus-pituitary-adrenal axis in piglets. Thirty-two crossbred (Duroc×Large White×Landrace) piglets with (8.91±0.74) kg BW weaned at （28±3） d of age were randomly allocated into 4 group with 4 replicates per group and 2 pigs (male∶female was 1∶1) in each replicate in a two-factorial design. The main factors consisted of diet (5% fish oil or 5% corn oil) and immunological challenge [lipopolysaccharide (LPS) or physiological saline]. The experiment lasted for 19 days. On day 19, pigs were injected intraperitoneally with either 150 μg/kg BW of LPS or an equivalent amount of sterile saline. Blood samples were collected at pre-injection (0 h), or 2, 4 h post-injection for analysis of tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), cortisol, adrenocorticotropic hormone (ACTH) and corticotrophin releasing hormone (CRH). The results showed that fish oil had no effects on production performance of piglets compared to corn oil (P>0.05). At 2 h post-injection, LPS challenge significantly increased contents of TNF-α, PGE2, ACTH and cortisol (P<0.01), LPS challenge×diet interactions were observed for TNF-α, PGE2, cortisol such as these measurements responded to the LPS challenge to a lesser extent in pigs receiving the fish oil diet than in pigs fed the corn oil diet (P<0.05). Pigs fed fish oil had lower ACTH level compared with those fed corn oil (P＜0.01) . At 4 h post-injection, LPS challenge significantly increased contents of TNF-α, PGE2, and cortisol (P<0.05). Among LPS-treated pigs, pigs fed fish oil had lower TNF-α than those fed corn oil (P<0.05). Pigs fed fish oil had lower PGE2 (P＜0.01) and ACTH levels (P＜0.05) compared with those fed corn oil, but fish oil had no effects on cortisol content (P>0.05). Both LPS and fish oil had no effect on CRH. These results suggest that fish oil alters hypothalamus-pituitary-adrenal axis, which may be due to the inhibition of pro-inflammatory cytokine during an immunological challenge.［Chinese Journal of Animal Nutrition, 2011, 23（6）：937 -942］
HONG Yu,LIU Yulan,WU Zhifeng,ZHU Huiling,HOU Yongqing,DING Bingying
. Effects of Fish Oil Supplementation on Production Performance, Inflammatory Parameters and Hypothalamus-Pituitary-Adrenal Axis in Piglets[J]. Chinese Journal of Animal Nutrition, 2011
, 23(06)
: 937
-942
.
DOI: 10.3969/j.issn.1006-267x.2011.06.008
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