This experiment was conducted to study the effects of lactoferricin B (Lfcin B) and cecropin P1 (Cec P1) on growth and gut microflora in weaned piglets after orally challenged with enterotoxigenic Escherichia coli (ETEC). Forty-eight 28-day-old German Landrace×German Landrace weaned piglets with average body weight of (7.18±1.32) kg were randomly assigned to four dietary treatments (the control, ETEC, LfcinB, Cec P1) with two replicates per treatment and six pigs per replicate. The feeding trial lasted for 12 days. The results showed as follows: 1) there were no significant differences in body weight and average daily gain among control, ETEC, Lfcin B and Cec P1 group (P>0.05). 2) The incidence of diarrhea in ETEC group was significantly higher than that in the other groups (P<0.05), but there was no significant difference among control, Lfcin B and Cec P1 group (P>0.05). After challenged with ETEC firstly, the content of dry matter in feces of 29-day-old weaned piglets in ETEC, Lfcin B and Cec P1 group was significantly decreased (P<0.05), and after challenged with ETEC secondly, the content of dry matter in feces of 31-day-old weaned piglets in ETEC and Lfcin B group was still significantly lower than that in the control group (P<0.05), but there was no significant difference between the control group and Cec P1 group. 3) There was no significant difference in gut microflora among all groups (P>0.05). In conclusion, there are no significant differences in the growth and gut microflora of weaned piglets among the control, ETEC, Lfcin B and Cec P1 group, however, because Cec P1 is separated from nematode Ascaris suum of gut microbe in pigs, it lives more easily in the gut than Lfcin B, and it is more favourable to the health of piglets.［Chinese Journal of Animal Nutrition, 2011, 23（9）：1536 -1544］
HOU Zhenping,YIN Yulong,WANG Wenjie,LIU Jingxi,SOUFFRANT W B
. Effects of Lactoferricin B and Cecropin P1 on Growth and Gut Microflora in Weaned Piglets Challenged with Enterotoxigenic Escherichia coli[J]. Chinese Journal of Animal Nutrition, 2011
, 23(09)
: 1536
-1544
.
DOI: 10.3969/j.issn.1006-267x.2011.09.012
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