This experiment was conducted to study the effects of zinc and calcitonin gene-related peptide (CGRP) on feed intake and its regulation mechanism of piglets. Thirty crossed-bred (Duroc×Landrace×Large White) pigs with an average body weight of 9.57 kg were randomly assigned to five groups (control group Ⅰ, trial group Ⅰ, trial groupⅡ, control group Ⅱ and trial group Ⅲ) with 6 piglets per group. Piglets in all the groups were fed with the same basal diet. The feeding trial lasted for 14 days. After 24-hour fasting (free access to water), piglets in control group Ⅰ, trial group Ⅰ and trial group Ⅱ were injected 0, 2 and 4 mg/kg BW zinc, and then slaughtered at 24-hour after injection. Piglets in control group Ⅱ and trial group Ⅲ were injected 0 and 0.05 mg/kg BW CGRP, and then slaughtered at 2-hour after injection. The results showed as follows: 1) compared with the control group Ⅰ, feed intake of trial group Ⅰ and trial group Ⅱ were significantly increased (P<0.05) and decreased (P<0.05), respectively. Compared with the control group Ⅱ, feed intake in trial group Ⅲ were significantly decreased (P<0.05). 2) There were no significant differences on serum glucose and leptin levels by injection of zinc （P＞0.05）, but the triglyceride (TG), insulin and glucagon levels were significantly decreased (P<0.05). Injection of CGRP significantly decreased serum glucose, TG and insulin levels (P<0.05) and increased glucagon levels (P<0.05), but had no effect on leptin levels （P＞0.05）. 3) Compared with the control group Ⅰ, the expression levels of NPY mRNA in trial group Ⅰ and trial group Ⅱ were significantly increased (P<0.05), but the CGRP and CCK mRNA expression levels were significantly decreased (P<0.05). Compared with the control group Ⅱ, the CGRP and CCK mRNA expression level were significantly increased (P<0.05), while NPY mRNA expression levels was decreased significantly (P<0.05) in trial group Ⅲ. These results indicate that zinc can stimulate intake of piglets through inducing NPY mRNA expression and inhibiting CGRP and CCK mRNA expression. However, CGRP can compromise feed intake of piglets by inhibiting NPY mRNA expression and inducing CGRP as well as CCK mRNA expression.［Chinese Journal of Animal Nutrition, 2011, 23（9）：1545 -1552］
WANG Kunkun,CAO Chonghai,SUN Jianyi,LIU Jianxin,QIAN Lichun
. Zinc and CGRP on Feed Intake of Piglets: Effects and Mechanism[J]. Chinese Journal of Animal Nutrition, 2011
, 23(09)
: 1545
-1552
.
DOI: 10.3969/j.issn.1006-267x.2011.09.013
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