Intrauterine growth retardation (IUGR) increases the risk of perinatal death and metabolic diseases in neonatal period as well as adult life, with multiple births animals more affected. In animal models, IUGR is usually induced by uterine arteries ligation, maternal caloric restriction and maternal protein restriction. Recently, many researches were conducted to study the consequences of IUGR on the endocrine of pancreas. Those studies have shown that IUGR impairs the development, differentiation and proliferation of pancreatic beta cells. In addition, IUGR leads to a decrease in beta cell mass and pancreatic insulin contents, as well as insulin secretion, and consequently induces metabolic diseases in adult life. This paper reviewed the effect of IUGR on the development of endocrine pancreas.［Chinese Journal of Animal Nutrition, 2011, 23（10）：1658 -1663］
KONG Lingrui,WANG Yuanxiao,WANG Tian
. Effect of Intrauterine Growth Retardation on Endocrine Function of Pancreas: a Review
[J]. Chinese Journal of Animal Nutrition, 2011
, 23(10)
: 1658
-1663
.
DOI: 10.3969/j.issn.1006-267x.2011.10.003
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