Effects of Lactoferrin Supplementation on Growth Performance, Intestinal Microflora and Mucosal Morphology of Early Weaned Piglets

LI Meijun, FANG Chengkun, ZHANG Kai, LI Yunhu, FANG Rejun

doi:10.3969/j.issn.1006-267x.2012.01.016

2012 , Vol. 24 >Issue 1: 111 - 116

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.01.016

Feed Science and Technology

Effects of Lactoferrin Supplementation on Growth Performance, Intestinal Microflora and Mucosal Morphology of Early Weaned Piglets

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1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. College of Orient Science and Technology, Hunan Agricultural University, Changsha 410128, China;
3. College of Hunan Biological and Electromechanical Polytechnic, Changsha 410127, China

Received date: 2011-07-14

Online published: 2012-01-13

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Abstract

This experiment was conducted to investigate the effects of lactoferrin(LF)on growth performance, intestinal microflora and mucosal morphology in early weaned piglets. Ninety-six piglets weaned at 21 days of age were randomly divided into four groups with four replicates in every group and 6 piglets in every replicate. The four groups were basal diet group, basal diet+250 mg/kg LF group, basal diet+500 mg/kg LF group and basal diet+750 mg/kg LF group, respectively. The experiment lasted for 21 days. The results showed that compared with the control and 750 mg/kg LF group, diets supplemented with 250 and 500 mg/kg LF could significantly improve average daily gain(P<0.05);compared with the control group,LF could reduce the sum of Escherichia coli in caecum(P<0.05). The supplementation of 500 mg/kg LF was significantly increased Lactobacillus number in caecum and colon(P<0.05)as well as significantly reduced Escherichia coli number in colon(P<0.05).The supplementation of 250 and 500 mg/kg LF were extremely significantly increased villus height to crypt depth ratio in duodenum, jejunum and ileum(P<0.01). The results indicate that supplementation of LF can improve the growth performance and regulate intestinal microflora as well as mucosal morphology. The optimum supplemental level of LF is 250 mg/kg under this experimental condition.

Key words： lactoferrin; growth performance; intestinal microflora; intestinal mucosal morphology; weaned piglets

Cite this article

LI Meijun, FANG Chengkun, ZHANG Kai, LI Yunhu, FANG Rejun . Effects of Lactoferrin Supplementation on Growth Performance, Intestinal Microflora and Mucosal Morphology of Early Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2012 , 24(1) : 111 -116 . DOI: 10.3969/j.issn.1006-267x.2012.01.016

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