Dietary Conjugated Linoleic Acid Affects Intestinal Mucosal Immunity Response of Broiler Chickens

LIU Yongxiang, LIU Yanli, XU Qiuliang, JIANG Dongfeng, YANG Jianping

doi:10.3969/j.issn.1006-267x.2012.01.018

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 1: 124 - 130

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.01.018

Feed Science and Technology

Dietary Conjugated Linoleic Acid Affects Intestinal Mucosal Immunity Response of Broiler Chickens

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1. Engineering Technology Research Center of Animal Nutrition and Feed, Henan University, Zhengzhou 450011, China;
2. Zhengzhou College of Animal Husbandry Engineering, Zhengzhou 450011, China

Received date: 2011-08-08

Online published: 2012-01-13

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Abstract

This experiment was conducted to investigate the effects of dietary conjugated linoleic acid (CLA) on the intestinal mucosal immunity response of broiler chickens. Seventy-two 1-day-old male Abor Acre (AA) broiler chickens were randomly allocated into two groups and fed a basal diet or a diet supplemented with 1% CLA, and each group contained six replicates with 6 chicks each and 6 chicks in each replicate. The brolier chickens were slaughtered at 21 days of age and samples were collected. Chicks fed the CLA supplementation diet had significantly higher jejunal chyme SIgA content and jejunum SIgA gene mRNA expression compared with those fed the basal diet (P<0.01). Jejunal peroxisome proliferator-activated receptor γ (PPARγ) gene mRNA expression was significantly enhanced in chicks fed the CLA supplementation diet than that in chicks fed the basal diet (P<0.01), but the transforming growth factor-β4 (TGFβ4) gene mRNA expression was not significantly different between them (P>0.05). Dietary CLA increased the percentages of CD8⁺ T cell subsets of Peyer's patch (P<0.01) and lymphocyte transformation rate (P<0.05). Dietary 1% CLA increases jejunum SIgA secretion, at least in part, through activating the PPARγ transcription. Dietary 1% CLA infulences the jejunal mucosal cell immunity response of broiler chickens.

Key words： CLA; broiler chickens; intestinal mucosal immunity

Cite this article

LIU Yongxiang, LIU Yanli, XU Qiuliang, JIANG Dongfeng, YANG Jianping . Dietary Conjugated Linoleic Acid Affects Intestinal Mucosal Immunity Response of Broiler Chickens[J]. Chinese Journal of Animal Nutrition, 2012 , 24(1) : 124 -130 . DOI: 10.3969/j.issn.1006-267x.2012.01.018

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