YANG Yongsheng, HE Jianhua, DENG Huizhong, XIE Hongbing, JIANG Bibo, LUO Jiajie . Myostain: Effects on Muscle, Fat and Bone of Animals[J]. Chinese Journal of Animal Nutrition, 2012 , 24(2) : 220 -225 . DOI: 10.3969/j.issn.1006-267x.2012.02.005

[1] BELLINGE R H, LIBERLES D A, IASCHI S P, et al. Myostatin and its implications on animal breeding: a review[J]. Animal Genetics, 2005, 36(1):1-6.  



[2] JOULIA-EKAZA D, CABELLO G. Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects[J]. Experimental Cell Research, 2006, 312(13):2401-2414.  



[3] MCPHERRON A C, LEE S J. Double muscling in cattle due to mutations in the myostatin gene[J]. Proceedings of the National Academy of Sciences of the United States of America, 1997, 94(23):12457-12461.  



[4] SHARMA M, KAMBADUR R, MATTHEWS K G, et al. Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct[J]. Journal of Cellular Physiology, 1999, 180(1):1-9.  



[5] LEE S J, MCPHERRON A C. Regulation of myostatin activity and muscle growth[J]. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98(16):9306-9311.  



[6] THOMAS M, LANGLEY B, BERRY C, et al. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation[J]. The Journal of Biological Chemistry, 2000, 275(51):40235-40243.  



[7] MCFARLANE C, LANGLEY B, THOMAS M, et al. Proteolytic processing of myostatin is auto-regulated during myogenesis[J]. Development Biology, 2005, 283(1):58-69.  



[8] BREITBART A, AUGER-MESSIER M, MOLKENTIN J D, et al. Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting[J]. American Journal of Physiology: Heart and Circulatory Physiology, 2011, 300:1973-1982.



[9] MCPHERRON A C, LAWLER A M, LEE S J. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member[J].Nature, 1997, 387(6628):83-90.  



[10] KAMBADUR R, SHARMA M, SMITH T P, et al. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle[J]. Genome Research, 1997, 7(9):910-916.



[11] BASS J, OLDHAM J, SHARMA M, et al. Growth factors controlling muscle development[J]. Domestic Animal Endocrinology, 1999, 17(2/3):191-197.



[12] OLDHAM J M, MARTYN J A, SHARMA M, et al. Molecular expression of myostatin and MyoD is greater in double-muscled than normal-muscled cattle fetuses[J]. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001, 280(5):1488- 1493.



[13] JI S, LOSINSKI R L, CORNELIUS S G, et al. Myostatin expression in porcine tissues: tissue specificity and developmental and postnatal regulation[J]. American Journal of Physiology, 1998, 275(4 Pt 2):1265-1273.



[14] WELLE S, BHATT K, SHAH B, et al. Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 year old men[J]. Experimental Gerontology, 2002, 37(6):833-839.  



[15] 杨晓静,陈杰,胥清富,等.二花脸猪和大白猪背最长肌中肌肉生长抑制素和生肌调节因子基因的表达及其性别特点[J].南京农业大学学报,2006,29(3):64-68.



[16] CARLSON C J, BOOTH F W, GORDON S E. Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading[J]. American Journal of Physiology, 1999, 277(2):601-606.



[17] GIRGENRATH S, SONG K, WHITTEMORE L A. Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscle[J]. Muscle and Nerve, 2005, 31(1):34-40.  



[18] MITCHELL M D, OSEPCHOOK C C, LEUNG K C, et al. Myostatin is a human placental product that regulates glucose uptake[J]. The Journal of Clinical Endocrinology & Metabolism, 2006, 91(4):1434-1437.  



[19] REBBAPRAGADA A, BENCHABANE H, WRANA J L, et al. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis[J]. Molecular and Cellular Biology, 2003, 23(20):7230-7242.  



[20] PIEK E, HELDIN C H, TEN DIJKE P. Specificity, diversity, and regulation in TGF-beta superfamily signaling[J]. The Journal of the Federation of American Societies for Experimental Biology, 1999, 13(15):2105-2124.



[21] NAKAO A, IMAMURA T, SOUCHELNYTSKYI S, et al. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4[J]. The EMBO Journal, 1997, 16(17):5353-5362.  



[22] SOUCHELNYTSKYI S, TAMAKI K, ENGSTROM U, et al. Phosphorylation of Ser⁴⁶⁵ and Ser⁴⁶⁷ in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling[J]. The Journal of Biological Chemistry, 1997, 272(44):28107-28115.  



[23] ZHANG Y, MUSCI T, DERYNCK R. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function[J]. Current Biology, 1997, 7(4):270-276.  



[24] ZHU X, TOPOUZIS S, LIANG L F, et al. Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism[J]. Cytokine, 2004, 26(6):262-272.  



[25] FORBES D, JACKMAN M, BISHOP A, et al. Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism[J]. Journal of Cellular Physiology, 2006, 206(1):264-272.  



[26] PHILIP B, LU Z, GAO Y. Regulation of GDF-8 signaling by the p38 MAPK[J]. Cellular Signalling, 2005, 17(3):365-375.  



[27] RIOS R, CARNEIRO I, ARCE V M, et al. Myostatin is an inhibitor of myogenic differentiation[J]. American Journal of Physiology-Cell Physiology, 2002, 282(5):993-999.



[28] WELLE S, BHATT K, PINKERT C A, et al. Muscle growth after postdevelopmental myostatin gene knockout[J]. American Journal of Physiology-Endocrinology and Metabolism, 2007, 292(4):985-991.



[29] WHITTEMORE L A, SONG K, LI X, et al. Inhibition of myostatin in adult mice increases skeletal muscle mass and strength[J]. Biochemical and Biophysical Research Communications, 2003, 300(4):965-971.  



[30] LEE S J. Regulation of muscle mass by myostatin[J]. Annual Review of Cell and Developmental Biology, 2004, 20:61-86.



[31] FELDMAN B J, STREEPER R S, FARESE R V, Jr., et al. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(42):15675-15680.  



[32] ARTAZA J N, BHASIN S, MAGEE T R, et al. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T (1/2) mesenchymal multipotent cells[J]. Endocrinology, 2005, 146(8):3547-3557.  



[33] REISZ-PORSZASZ S, BHASIN S, ARTAZA J N, et al. Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin[J]. American Journal of Physiology: Endocrinology and Metabolism, 2003, 285(4):876-888.



[34] ELKASRAWY M N, HAMRICK M W. Myostatin (GDF-8) as a key factor linking muscle mass and bone structure[J]. Journal of Musculoskeletal and Neuronal Interactions, 2010, 10(1):56-63.



[35] HAMRICK M W, MCPHERRON A C, LOVEJOY C O. Bone mineral content and density in the humerus of adult myostatin-deficient mice[J]. Calcified Tissue International, 2002, 71(1):63-68.  



[36] HAMRICK M W, MCPHERRON A C, LOVEJOY C O, et al. Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice[J]. Bone, 2000, 27(3):343-349.  



[37] HAMRICK M W. Increased bone mineral density in the femora of GDF8 knockout mice[J]. Anatomical Record Part A: Discoveries in Molecular Cellular and Evolutionary Biology, 2003, 272(1):388-391.



[38] CHO T J, GERSTENFELD L C, EINHORN T A. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing[J]. Journal of Bone and Mineral Research, 2002, 17(3):513-520.  



[39] GUO W, FLANAGAN J, JASUJA R, et al. The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways[J]. The Journal of Biological Chemistry, 2008, 283(14):9136-9145.  



[40] NAGAMINE T, IMAMURA T, ISHIDOU Y, et al. Immunohistochemical detection of activin A, follistatin, and activin receptors during fracture healing in the rat[J]. Journal of Orthopaedic Research, 1998, 16(3):314-321.  



[41] MENDIAS C L, BAKHURIN K I, FAULKNER J A. Tendons of myostatin-deficient mice are small, brittle, and hypocellular[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1):388-393.  



[42] ZHANG L, RAJAN V, LIN E, et al. Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease[J]. The Journal of the Federation of American Societies for Experimental Biology, 2011, 25(5):1653-1663.



[43] MCPHERRON A C, LEE S J. Suppression of body fat accumulation in myostatin-deficient mice[J]. The Journal of Clinical Investigation, 2002, 109(5):595-601.



[44] GUO T, JOU W, CHANTURIYA T, et al. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity[J]. Public Library of Science One, 2009, 4(3):4937.