Effects of Nano Zinc Oxide on Growth Performance and Intestinal Mucosal Barrier in Weaner Piglets

HU Caihong, YOU Zhaotong, ZHU Kang, LUAN Zhaoshuang

doi:10.3969/j.issn.1006-267x.2012.02.014

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 2: 285 - 290

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.02.014

Feed Science and Technology

Effects of Nano Zinc Oxide on Growth Performance and Intestinal Mucosal Barrier in Weaner Piglets

Expand

1. Institute of Feed Science, Zhejiang University, Hangzhou 310058, China;
2. Institute of Virology and Biotechnology Research, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received date: 2011-10-19

Online published: 2012-02-07

Fold

Abstract

This experiment was conducted to study the effects of nano zinc oxide on growth performance and intestinal mucosal barrier in weaner piglets. Ninety-six 'Duroc × Landrace × Yorkshire’ crossbred piglets with an average body weight of (5.7±0.2) kg were weaned at 21 days of age and randomly allocated into control group, zinc oxide group and nano zinc oxide group (4 replicates in each group and 8 piglets per replicate). A basal diet was the diet of control group, a basal diet supplemented with 3 000 mg/kg zinc as zinc oxide was the diet of zinc oxide group, and a basal diet supplemented with 300 mg/kg zinc as nano zinc oxide was the diet of nano zinc oxide group, respectively. Feeding trial lasted for 14 days. The results showed that the diet of nano zinc oxide group improved average daily gain (P<0.05) and decreased diarrhea rate of piglets (P<0.05) compared with the diet of control group. There was no significant difference in growth performance and diarrhea rate between the piglets of nano zinc oxide group and the piglets of zinc oxide group (P>0.05). The piglets of nano zinc oxide group had higher villus height and villus height/crypt depth (P<0.05), lower plasma D-lactate content and diamine oxidase activity (P<0.05) compared with the piglets of control group. No significant difference in intestinal mucosal barrier was found between the piglets of nano zinc oxide group and the piglets of zinc oxide group (P>0.05). The results indicate that the diet supplemented with 300 mg/kg zinc as nano zinc oxide can protect intestinal mucosal barrier, decrease diarrhea rate and improve growth performance, which is comparable to the effect of the diet supplemented with 3 000 mg/kg zinc as zinc oxide.

Key words： nano zinc oxide; weaner piglets; diarrhea rate; intestinal mucosal barrier

Cite this article

HU Caihong, YOU Zhaotong, ZHU Kang, LUAN Zhaoshuang . Effects of Nano Zinc Oxide on Growth Performance and Intestinal Mucosal Barrier in Weaner Piglets[J]. Chinese Journal of Animal Nutrition, 2012 , 24(2) : 285 -290 . DOI: 10.3969/j.issn.1006-267x.2012.02.014

References

[1] LALLES J P,BOSI P,SMIDT H,et al.Weaning-A challenge to gut physiologists[J].Livestock Science,2007,108(1/2/3):82-93.

[2] VALLEE B L,FALCHUK K H.The biochemical basis of zinc physiology[J].Physiological Reviews,1993,73(1):79-118.

[3] DAVIS M E,BROWN D C,MAXWELL C V,et al.Effect of phosphorylated mannans and pharmacological additions of zinc oxide on growth and immunocompetence of weanling pigs[J].Journal of Animal Science,2004,82(2):581-587.

[4] HEO J M,KIM J C,HANSEN C F,et al.Effects of dietary protein level and zinc oxide supplementation on the incidence of post-weaning diarrhoea in weaner pigs challenged with an enterotoxigenic strain of Escherichia coli[J].Livestock Science,2010,133(1/2/3):210-213.

[5] 计峰,罗绪刚,李素芬,等.高锌对断乳仔猪促生长作用及其机理的研究进展[J].动物营养学报,2003,15(3):1-5.

[6] 周维仁,邹思湘,李松岩,等.高铜高锌日粮在猪体内的代谢规律及对土壤污染的评估[J].江苏农业科学,2011,39(2):290-294.

[7] POULSEN H D.Zinc and copper as feed additives,growth factors or unwanted environmental factors[J].Journal of Animal and Feed Sciences,1998,7:135-142.

[8] 王之盛,况应谷,任守国,等.纳米氧化锌对仔猪生产性能和粪便微生物群落的影响[J].中国畜牧杂志,2006,42(9):22-24.

[9] 马恒东,王之盛,周安国,等.翻转肠囊法研究仔猪小肠对纳米氧化锌的吸收[J].中国畜牧杂志,2005,41(9):25-26.

[10] 田丽娜,朱风华,任慧英,等.纳米氧化锌对肉仔鸡抗氧化性能的影响[J].动物营养学报,2009,21(4):534-539.

[11] 丁小波,文利新,袁慧.纳米氧化锌对AA肉鸡肝脏金属硫蛋白的影响[J].中国兽医学报,2009,29(2):242-244.

[12] 徐奇友,刘立波,侯奉雨,等.纳米氧化锌对肉仔鸡血清生化指标的影响[J].动物营养学报,2007,19(1):76-80.

[13] 胡彩虹,钱仲仓,刘海萍,等.高锌对早期断奶仔猪肠黏膜屏障和肠上皮细胞紧密连接蛋白表达的影响[J].畜牧兽医学报,2009,40(11):1638-1644.

[14] HOET P H,BRVSKE-HOHLFELD I,SALATA O V.Nanoparticles-known and unknown health risks[J].Journal of Nanobiotechnology,2004,2(1):12.

[15] DESAI M P,LABHASETWAR V,AMIDON G L,et al.Gastrointestinal uptake of biodegradable microparticles:effect of particle size[J].Pharmaceutical Research,1996,13(12):1838-1845.

[16] 张立德.纳米材料和纳米结构[M].北京:科学出版社,2001.

[17] 李彦峰,汪斌华,黄婉霞,等.纳米无机抗菌材料抗菌性能研究[J].化工新型材料,2002,30(6):44-46.

[18] 吴诚,文利新,袁慧,等.纳米氧化锌对小鼠的毒性试验[J].粮食与饲料工业,2008(5):38-39.

[19] 杨辉,杨丹凤,张华山,等.4种典型纳米材料对小鼠胚胎成纤维细胞毒性的初步研究[J].生态毒理学报,2007,2(4):427-434.

[20] CARLSON M S,HILL G M,LINK J E.Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide: effect on metallothionein and mineral concentrations[J].Journal of Animal Science,1999,77(5):1199-1207.

[21] 刘海萍,胡彩虹,徐勇.早期断奶对仔猪肠通透性和肠上皮紧密连接蛋白Occludin mRNA表达的影响[J].动物营养学报,2008,20(4):442-446.

[22] 徐勇,刘海萍,胡彩虹.高锌对早期断奶仔猪肠形态和肠屏障通透性的影响[J].浙江大学学报:农业与生命科学版,2009,35(2):209-214.

[23] ROSELLI M,FINAMORE A,GARAGUSO I,et al.Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli[J].The Journal of Nutrition,2003,133(12):4077-4082.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References