Mechanism of Action of Probiotic Function of Lactobacilli

  • ZHANG Wenming ,
  • WANG Haifeng ,
  • LIU Jianxin
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  • 1. National Engineering Laboratory of Biofeed Safety & Pollution Control, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China;
    2. College of Forestry and Biotechnology, Zhejiang A & F University, Lin'an 311300, China

Received date: 2011-10-11

  Online published: 2012-02-28

Supported by

国家自然科学基金(30901043,30901043);中国博士后科学基金(20090461387);浙江省自然科学基金(Y3090050)

Abstract

Lactobacilli have been widely applied to exert health benefits for human and animals. This article reviewed the recent advances in the mechanisms underlying the health-promoting functions of Lactobacilli. Lactobacilli can secrete antimicrobial compounds (lactic acid, H2O2 or bacteriocin), or compete with pathogenic bacteria for nutrient or attachment site in the intestinal tract. Probiotic Lactobacilli are suggested to strengthen the epithelial barrier by induction of mucin secretion or prevention of epithelial cell apoptosis. This review focused on Lactobacilli surface factors such as surface protein, teichoic acids and peptidoglycan, and their intestinal receptors (C-type lectin receptor, toll-like receptor, and nucleotide binding oligomerization domain-like receptors, NLRs). Their combination may modulate immune signaling pathways and promote immune function in the gut, resulting in beneficial effects on host.

Cite this article

ZHANG Wenming , WANG Haifeng , LIU Jianxin . Mechanism of Action of Probiotic Function of Lactobacilli[J]. Chinese Journal of Animal Nutrition, 2012 , 24(3) : 389 -396 . DOI: 10.3969/j.issn.1006-267x.2012.03.001

References

[1] SERVIN A L.Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens[J].FEMS Microbiology Reviews,2004,28:405-440.
[2] DE KEERSMAECKER S C J,VERHOEVEN T L A,DESAIR J,et al.Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid[J].FEMS Microbiology Letters,2006,259:89-96.
[3] OGAWA M,SHIMIZU K,NOMOTO K,et al.Inhibition of in vitro growth of Shiga toxin-producing Escherichia coli O157∶H7 by probiotic Lactobacillus strains due to production of lactic acid[J].International Journal of Food microbiology,2001,68:135-140.
[4] OTERO M C,NADER-MACAS M E.Inhibition of Staphylococcus aureus by H2O2-producing Lactobacillus gasseri isolated from the vaginal tract of cattle[J].Animal Reproduction Science,2006,96:35-46.
[5] PRIDMORE R D,PITTET A C,PRAPLAN F,et al.Hydrogen peroxide production by Lactobacillus johnsonii NCC 533 and its role in anti-Salmonella activity[J].FEMS Microbiology Letters,2008,283:210-215.
[6] VOLTAN S,MARTINES D,ELLI M,et al.Lactobacillus crispatus M247-Derived H2O2 acts as a signal transducing molecule activating peroxisome proliferator activated receptor-γ in the intestinal mucosa[J].Gastroenterology,2008,135:1216-1227.
[7] EIJSINK V G,AXELSSON L,DIEP D B,et al.Production of class Ⅱ bacteriocins by lactic acid bacteria; an example of biological warfare and communication[J].Antonie Van Leeuwenhoek,2002,81:639-654.
[8] CORR S C,LI Y,RIEDEL C U,et al.Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104:7617-7621.
[9] SONNENBURG J L,CHEN C T L,GORDON J I.Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host[J].PLoS Biology,2006,4:2213-2226.
[10] NIKOSKELAINEN S,SALMINEN S,BYLUND G,et al.Characterization of the properties of human- and dairy-derived probiotics for prevention of infectious diseases in fish[J].Applied and Environmental Microbiology,2001,67:2430-2435.
[11] KMET V,CALLEGARI M L,BOTTAZZI V,et al.Aggregation-promoting factor in pig intestinal Lactobacillus strains[J].Letters in Applied Microbiology,1995,21:351-353.
[12] COLLADO M C,SURONO I S,MERILUOTO J,et al.Potential probiotic characteristics of Lactobacillus and Enterococcus strains isolated from traditional dadih fermented milk against pathogen intestinal colonization[J].Journal of Food Protection,2007,70:700-705.
[13] CHEN X Y,XU J J,SHUAI J B,et al.The S-layer proteins of Lactobacillus crispatus strain ZJ001 is responsible for competitive exclusion against Escherichia coli O157∶H7 and Salmonella typhimurium[J].International Journal of Food Microbiology,2007,115:307-312.
[14] YAN F,CAO H W,COVER T L,et al.Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth[J].Gastroenterology,2007,132:562-575.
[15] RESTA-LENERT S,BARRETT K E.Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells[J].Gastroenterology,2006,130:731-746.
[16] YAN F,POLK D B.Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells[J].Journal of Biological Chemistry,2002,277:50959-50965.
[17] VIDAL K,DONNET-HUGHES A,GRANATO D.Lipoteichoic acids from Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus strain La10 antagonize the responsiveness of human intestinal epithelial HT29 cells to lipopolysaccharide and gram-negative bacteria[J].Infection and Immunity,2002,70:2057-2064.
[18] FUJIYA M,MUSCH M W,NAKAGAWA Y,et al.The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2,a host cell membrane transporter[J].Cell Host & Microbe,2007,1:299-308.
[19] SCHIFFRIN E J,ROCHAT F,LINK-AMSTER H,et al.Immunomodulation of human blood cells following the ingestion of lactic acid bacteria[J].Journal of Dairy Science,1995,78:491-497.
[20] YAMAMOTO M,AKIRA S.Mechanisms of innate immune responses mediated by Toll-like receptors[J].Clinical and Applied Immunology Reviews,2005,5:167-183.
[21] 汪海峰,章文明,汪以真,等.乳酸杆菌与肠道黏附相关表面因子及机制研究进展[J].动物营养学报,2011,23(2):179-186.
[22] BERGONZELLI G E,GRANATO D,PRIDMORE R D,et al.GroEL of Lactobacillus johnsonii La1 (NCC 533) is cell surface associated:potential role in inter-actions with the host and the gastric pathogen Helicobacter pylori[J].Infection and Immunity,2006,74:425-434.
[23] GRANATO D,BERGONZELLI G E,PRIDMORE R D,et al.Cell surface-associated elongation factor Tu mediates the attachment of Lactobacillus johnsonii NCC533 (La1) to human intestinal cells and mucins[J].Infection and Immunity,2004,72:2160-2169.
[24] KONSTANTINOV S R,SMIDT H,DE VOS W M,et al.S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions[J].Proceedings of National Academy Sciences of the United States of America,2008,105(49):19474-19479.  
[25] SU S C,HUA K F,LEE H,et al.LTA and LPS mediated activation of protein kinases in the regulation of inflammatory cytokines expression in macrophages[J].Clinica Chimica Acta,2006, 374:106-115.
[26] MATSUGUCHI T,TAKAGI A,MATSUZAKI T,et al.Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2[J].Clinical and Diagnostic Laboratory Immunology,2003,10:259-266.
[27] SHIDA K,KIYOSHIMA-SHIBATA J,KAJI R,et al.Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms[J].Immunology,2009,128:858-869.
[28] ENGERING A,GEIJTENBEEK T B H,VAN VLIET S J,et al.The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells[J].The Journal of Immunology,2002,168:2118-2126.
[29] WEIS W I,TAYLOR M E,DRICKAMER K.The C-type lectin superfamily in the immune system[J].Immunological Reviews,1998,163:19-34.
[30] TAKEDA K,KAISHO T,AKIRA S.Toll-like receptors[J]. Annual Review Immunology,2003,21:335-376.
[31] AKIRA S,TAKEDA K.Toll-like receptor signaling[J].Nature Reviews Immunology,2004,4:499-511.
[32] UNDERHILL D M,OZINSKY A.Toll-like receptors: key mediators of microbe detection[J].Current Opinion in Immunology,2002,14:103-110.
[33] ADEREM A,ULEVITCH R J.Toll-like receptors in the induction of the innate immune response[J]. Nature,2000,406:782-787.
[34] LEBOURHIS L,BENKO S,GIRARDIN S E.Nod1 and Nod2 in innate immunity and human inflammatory disorders[J]. Biochemical Society Transactions,2007,35:1479-1484.
[35] MALDONADO-CONTRERAS A L,MCCORMICK B A.Intestinal epithelial cells and their role in innate mucosal immunity[J].Cell and Tissue Research,2011,343:5-12.
[36] LEBEER S,VANDERLEYDEN J,DE KEERSMAECKER S C.Genes and molecules of lactobacilli supporting probiotic action[J].Microbiology and Molecular Biology Reviews,2008,74:728-764.
[37] KOBAYASHI K S,CHAMAILLARD M,OGURA Y,et al.Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract[J].Science,2005,307:731-734.
[38] KOBAYASHI K, NOHARA N,HERNANDEZ L D,et al.RICK/Rip2/CARDIAK mediates signaling for receptors of the innate and adaptive immune systems[J].Nature,2002,416:194-199.
[39] YAMAMOTO-FURUSHO J K,BARNICH N,XAVIER R,et al.Centaurin β1 down-regulate nucleotide-binding oligomerization domains 1- and 2-dependent NF-κB activation[J].The Journal of Biology Chemistry,2006,281:36060-36070.
[40] WILMANSKI J M,PETNICKI-OCWIEJA T,KOBAYASHI K S.NLR proteins:integral members of innate immunity and mediators of inflammatory diseases[J].Journal of Leukocyte Biology,2008,83:13-30.
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