Regulation of Intestinal Mucosal Immunity by Intestinal Flora in Animals

  • LEI Chunlong ,
  • DONG Guozhong
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  • Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Chongqing 400716, China

Received date: 2011-09-13

  Online published: 2012-02-28

Supported by

国家"973计划"项目资助(2011CB100800)

Abstract

There exists a huge amount of flora with complex structures in the animals' intestine; also, there are many powerful mucosal lymphocytes within the intestinal wall. The intestinal flora plays an important role both in promoting growth and development of the intestinal mucosal immune system and in regulating intestinal mucosal barrier and immune functions. This paper reviews the colonization and characteristics of the intestinal flora, the function of intestinal mucosal immune cells, as well as the regulation of intestinal mucosal barrier and immune functions by the intestinal flora.

Cite this article

LEI Chunlong , DONG Guozhong . Regulation of Intestinal Mucosal Immunity by Intestinal Flora in Animals[J]. Chinese Journal of Animal Nutrition, 2012 , 24(3) : 416 -422 . DOI: 10.3969/j.issn.1006-267x.2012.03.005

References

[1] VINCENTER B.Vaccination for app is even useful when mortality is low[J].Livestock Science,2007,109:174-178.
[2] TANNOCK G W,SVAGE D C.Influences of dietary and environmental stress on microbial population in the murine gastrointestinal tract[J].Infection and Immunity,1974,9(3):591-598.
[3] CUKROWSKA B,KOZAKOVA H,REHAKOVA Z,et al.Specific antibody and immunoglobulin responses after intestinal colonization of germ-free piglets with non-pathogenic Escherichia coli O86[J].Immunobiology,2001,204(4):425-433.  
[4] BRANDTZAG P,FARSTAD N,JOHANSEN F E,et al.The B-cell system of human mucosae and exocrine glands[J].Immunological Reviews,1999,171(1):45-87.  
[5] JIANG Y,MCGEE D W.Regulation of human lymphocyte IL-4 secretion by intestinal epithelial cell derived interleukin-7 and transforming growth factor-β[J].Clinical Immunology and Immunopathology,1998,88(3):287-296.  
[6] CERUTTI A,RESCIGNO M.The biology of intestinal immunoglobulin A responses[J].Immunity,2008,28(6):740-750.  
[7] SUZULI K,MEEK B,DOI Y,et al.Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(7):1981-1986.  
[8] CAMERINI V,SYDORA B C,ARANDA R,et al.Generation of intestinal mucosal lymphocyte in SCD mice reconstituted with mature thymus derived T cell[J].The Journal of Immunology,1998,160(6):2608-2618.
[9] CHRISTENSEN H R,FROKIAER H,PESTKA J J.Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells[J].The Journal of Immunology,2002,168(1):171-178.
[10] ZYREK A A,CICHON C,HELMS S.Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair[J].Cell Microbiology,2007,9(3):804-816.  
[11] UKENA S N,SINGH A,DRINGENBERG U,et al.Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity[J].Public Library of Science,2007,2(12):e1308.
[12] LINDFORS K,BLOMQVIST T,JUUTI-UUSITALO K,et al.Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture[J].Clinical & Experimental Immunology,2008,152(3):552-558.  
[13] CANDELA M,PERNA F,CARNEVALI P,et al.Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells:adhesion properties,competition against enteropathogens and modulation of IL-8 production[J].International Journal of Food Microbiology,2008,125(3):286-292.  
[14] YAN F,CAO H,COVER T L,et al.Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth[J].Gastroenterology,2007,132(2):562-575.  
[15] BUNEO J,TORRES M,ALMENDROS A,et al.Effect of dietary nucleotide on small intestinal repair after diarrhea.Histological and ultrastructural change[J].Gut,1994,35(8):926-933.
[16] BAUMGART D C,DIGNASS A U.Intestinal barrier function[J].Current Opinion in Clinical Nutrition & Metabolic Care,2002,5(6):685-694.  
[17] GAUFFIN P G,AGUERO G,PERDIGON G.Adjuvant effects of Lactobacillus casei added to a renutrition diet in malnourished mouse model[J].Biology Cell,2002,26(1):35-48.  
[18] LEE Y K,LIM C Y,TENG W L,et al.Quantitative approach in the study of adhesion of lactic acid bacteria to intestinal cells and their competition with enterobacteria[J].Applied and Environmental Microbiology,2000,66(9):3692-3697.  
[19] WELSH D A,MASON C M.Host defense in respiratory infections[J].Medical Clinics of North America,2001,85(6):1329-1347.  
[20] MANTIS N J,CHEUNG M C,CHINTALACHARUVU K R,et al.Selective adherence of IgA to murine Peyer's patch M cells:evidence for a novel IgA receptor[J].The Journal of Immunology,2002,169(4):1844-1851.
[21] KOBAYASHI K S,CHAMAILLARD M,OGURA Y,et al.Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract[J].Science,2005,307:731-734.
[22] HELGLAND L,VAAGE J T,KOALTAD B,et al.Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine[J].Immunology,1996,89(4):494-501.  
[23] MONICA R,MARIA R.Uptake and presentation of orally administered antigens[J].Vaccine,2005,23(15):1793-1796.  
[24] JALIL B,CZARNECK M,CHRISTOPH C,et al.Supplementation of food with Enterococcus faecium (SF68) stimulates immune functions in young dogs[J].The Journal of Nutrition,2003,133:158-1162.
[25] SALMINEN S,ISOLAURI E,SALMINEN E.Clinical use of probiotics for stabilizing the gut mucosal barrier:successful strains and future challenges[J].Antonie Van Leeuwenhoek,1996,70(2):347-358.  
[26] KONSTANTINOV S R,SMIDT H,DEVOS W M,et al.S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(49):19474-19479.  
[27] GORCZYNSKI R M,LEE L,BOUDAKOU I.Augmented induction of CD4+ CD25+ Treg using monoclonal antibodies to CD200R[J].Transplantation,2005,79(9):488-491.
[28] MARLS N A,DESSINGD M C,DEVOS A F,et al.Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin[J].European Respiratory Journal,2006,28(3):622-626.  
[29] SUDO N,SAWAMMURA S,TANAKA K,et al.The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction[J].The Journal of Immunology,1997,159(4):1739-1745.
[30] KIRJAVAINEN P V,APOSTDOU E,SALMINEN S J,et al.New aspects of probiotics a novel approach in the management of food allergy[J].Allergy,1999, 54(9):909-915.  
[31] DUCHMANN R,KAISER I,HARMANN E,et al.Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)[J].Clinical & Experimental Immunology,1995,102(3):448-455.
[32] SINGN B,READ S,ASSEMAN C,et al.Control of intestinal inflammation by regulatory T cells[J].Immunological Reviews,2001,182(9):190-200.
[33] DUGA B,MERCENIER A,LENOIR-WIJNKOOP I,et al.Immunity and probiotics[J].Immunology Today,1999,20(9):387-390.  
[34] TAKAHASHI I.Mucosal immune system:the second way of the host defense[J].Japanese Journal of Clinical Medicine,2007,65(2):102-108.
[35] TIM L.Probiotics may alter intestinal immune function in broilers[J].Feedstuffs,2001,8(6):9.
[36] MEDICI M,VINDEROLA C G,PERDIGON G.Gut mucosal immunomodulation by probiotic fresh cheese[J].International Dairy Journal,2004,14(7):611-618.  
[37] DEMORENO D E,LEBLANC A,CHAVES S,et al.Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages[J].Immunobiology,2008,213(2):97-108.  
[38] MA D,FORSYTHE P,BIENENSTOCK J.Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression[J].Infection and Immunity,2004,72(9):5308-5314.  
[39] DOGI C A,GALDEANO C M,PERDIGON G.Gut immune stimulation by non pathogenic Gram (+) and Gram (-) bacteria.Comparison with a probiotic strain[J].Cytokine,2008,41(3):223-231.  
[40] HANSEN J,GULATI A,SARTOR R B.The role of mucosal immunity and host genetics in defining intestinal commensal bacteria[J].Current Opinion in Gastroenterology,2010,26(6):564-571.  
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