Lipoic Acid: Effects on Growth Performance, Antioxidant Capacity and Immune Function in Yellow-Feathered Broilers

LI Xing; CHEN Xiaolian; ZHU Lihui; WU Hongmei; WANG Yafen; XU Congcong; GU Juan; XU Jianxiong

doi:10.3969/j.issn.1006-267x.2012.03.018

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 3: 515 - 521

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.03.018

Lipoic Acid: Effects on Growth Performance, Antioxidant Capacity and Immune Function in Yellow-Feathered Broilers

LI Xing ,
CHEN Xiaolian ,
ZHU Lihui ,
WU Hongmei ,
WANG Yafen ,
XU Congcong ,
GU Juan ,
XU Jianxiong

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1. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China;
2. Key Laboratory for Veterinary and Biotechnology, Shanghai 200240, China;
3. Shanghai Xiangchuan Feed Company, Shanghai 201613, China

Received date: 2011-09-29

Online published: 2012-02-28

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Abstract

The study was conducted to investigate the effects of lipoic acid on growth performance, antioxidant capacity and immune function in yellow-feathered broilers. Sixty 21-day-old yellow-feathered broiler chickens with the similar body weight were randomly divided into control group and lipoic acid group, and there were 5 replicates per group and 6 broilers per replicate. The control group was fed a basal diet, and the lipoic acid group was fed the basal diet supplemented with 300 mg/kg lipoic acid. The experiment period was 30 days. The results showed that lipoic acid supplementation in the diet did not significantly affect growth performance (P>0.05), but promoted the development of spleen (P<0.05), increased total superoxide dismutase activity (P<0.05) and immunoglobulin G content (P<0.01), and decreased nitric oxide content (P<0.05) in serum of broilers on the 15th day of the experiment; lipoic acid supplementation in the diet decreased serum malondialdehyde content (P<0.05), and increased the capacity of scavenging ·OH (P<0.01) and immunoglobulin G content (P<0.05) in serum and the lymphocyte transformation rate stimulated by concanavalin A and lipopolysaccharide in peripheral blood (P<0.05) of broilers on the 30th day of the experiment. In conclusion, the supplementation of lipoic acid in the diet can enhance antioxidant capacity and immune function in broilers.

Key words： lipoic acid; growth performance; antioxidant capacity; immune function; yellow-feathered broilers

Cite this article

LI Xing , CHEN Xiaolian , ZHU Lihui , WU Hongmei , WANG Yafen , XU Congcong , GU Juan , XU Jianxiong . Lipoic Acid: Effects on Growth Performance, Antioxidant Capacity and Immune Function in Yellow-Feathered Broilers[J]. Chinese Journal of Animal Nutrition, 2012 , 24(3) : 515 -521 . DOI: 10.3969/j.issn.1006-267x.2012.03.018

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