[1] THANNICKAL V J,FANBURG B L.Reactive oxygen species in cell signaling pathway[J].American Journal of Physilogy-Lung Cellular and Molecular Physiology,2000,279:1005-1028.
[2] CRAWFORD D,AMSTAD P,ZBINDEN I,et al.Oxidant stress induces the proto-oncogenes
c-fos and
c-myc in mouse epidermal cells[J].Oncogene,1988,3:27-32.
[3] DEVARY Y,GOTTIEB R A,LAU L F,et al.Rapid and preferential activation of the
c-jun gene during the mammalian UV response[J].Molecular Cellular Biology,1991,11:2804-2811.
[4] NOSE K,SHIBANUMA M,KIKUCHI K,et al.Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line[J].European Journal Biochemistry,1991,201:99-106.
[5] DARNELL J E Jr.Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway[J].Journal of Interferon Cytokine Research,1998,18:549-554.
[6] SCHIEFFER B,LUCHTEFELD M,BRAUN S,et al.Role of NAD(P)H oxidase in angiotensin Ⅱ-induced JAK/STAT signaling and cytokine induction[J].Circulation Research,2000,87:1195-2001.
[7] GROTE M,LUCHTEFELD M,SCHIEFFER B.JANUS under stress-role of JAK/STAT signaling pathway in vascular diseases[J].Vascular Pharmacology,2005,43:357-363.
[8] HOU Y C,JANCZUK A,WANG P G.Current trends in the development of nitric oxide donors[J].Current Pharmaceutical Design,1999,5(6):417-471.
[9] LE BELLE J E,OROZCO N M,PAUCAR A A,et al.Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner[J].Cell Stem Cell,2011,8(1):59-71.

[10] LOH K,DENG H,FUKUSHIMA A,et al.Reactive oxygen species enhance insulin sensitivity[J].Cell Metabolism,2009,10:260-272.
[11] LINNANE A W,KIOS M,VITETTA L.Coenzyme Q10-Its role as a prooxidant in the formation of superoxide anion/hydrogen peroxide and the regulation of the metabolome[J].Mitochondrion,2007,7:51-61.
[12] ST-PIERRE J,BUCKINGHAM J,ROEBUCK S J,et al.Topology of superoxide production from different sites in the mitochondrial electron transport chain[J]. The Journal of Biological Chemistry,2002,277:44784-44790.
[13] NOHL H,GILLE L,STANIE K.Intracellular generation of reactive oxygen species by mitochondria[J].Biochemical Pharmacology,2005,69:719-723.
[14] CHANCE B,SIES H,BOVERIS A.Hydroperoxide metabolism in mammalian organs[J].Physiological Reviews,1979,59:527-605.
[15] 胡文琴,王恬,孟庆利.动物中活性氧的产生及清除机制[J].家畜生态,2004,25(3):64-67.
[16] WILLCOX D C,WILLCOX B J,TODORIKI H,et al.Caloric restriction and human longevity:what can we learn from the Okinawans?[J].Biogerontology,2006,7:173-177.
[17] REDMAN L M,HEIBRONN L K,MARTIN C K,et al.Metabolic and behavioral compensations in response to caloric restriction:implications for the maintenance of weight loss[J].PLoS One,2009,4(2):1-9.
[18] STREEKUMAR R,UNNIKRISHNAN J,FU A,et al.Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle[J].American Journal of Physiology-Endocrinology and Metabolism,2002,283(1):38-43.
[19] 彦怀城,刘同华.A族维生素的抗氧化和促氧化作用[J].中国药业,2006,15(20):3-5.
[20] CHIU H J,FISCHMAN D A,HAMMERLING U.Vitamin A depletion causes oxidative stress, mitochondrial dysfunction,and PARP-1-dependent energy deprivation[J].The Journal of the Federation of American Societies for Experimental Biology,2008,22:3878-3887.
[21] 韩磊,马爱国,张燕.维生素A干预对大鼠抗氧化能力及细胞膜流动性影响的研究[J].卫生研究,2004,33(4):450-452.
[22] KHOPDE S M,PRIYADSINI K I,MUKHERJEE T,et al.Does β-carotene protect memebrane lipids from nitrogen dioxide[J].Free Radical Biology & Medicine,1998,25(1):66-71.

[23] KLEINJANS J C,VAN HERWIJNEN M H,VAN MAANEN J M,et al.
In vitro investigations into the interaction of beta-carotene with DNA: evidence for the role of carbon-centered free radicals[J].Carcinogenesis,2004,25(7):1249-1256.

[24] 沈莉,王胜,谢芳,等.β-胡萝卜素对心肌细胞缺氧损伤的保护作用的研究[J].营养学报,2001, 23(2):164-166.
[25] ZHANG P,OMAYE S T.DNA strand breakage and oxygen tension: effect of β-carotene,α-tocopherol and ascorbic acid[J].Food Chemical Toxicology,2001,39:239-346.
[26] 任国峰,黄忆明,刘富强.维生素A对妊期大鼠脂质过氧化及抗氧化系统的影响[J].实用预防医学,2001,8(3):173-175.
[27] PALOZZA P,SERINI S,TORSELLO A,et al.Regulation of cell cycle progression and apoptosis by β-carotene in undifferentiated and differentiated HL-60 leukemia cells:possible involvement of a redox mechanism[J].International Journal of Cancer,2002,97:593-600.
[28] PALOZZA P,SERINI S,DI NICUOLO F,et al.Prooxidant effects of β-carotene in cultured cells[J].Molecular Aspects of Medicine,2003,24:353-362.
[29] MURATA M,KAWANISHI S.Oxidative DNA damage by vitamin A and its derivative via superoxide generation[J].Journal of Biological Chemistry,2000,275:2003-2008.
[30] BURTON G W,INGOLD K U.beta-Carotene:an unusual type of lipid antioxidant[J].Science,1984,224(4649):569-573.

[31] TRUSCOTT T G.β-carotene and disease:a suggested pro-oxidant and anti-oxidant mechanism and speculations concerning its role in cigarette smoking[J].Journal of Photochemistry and Photobiology B:Biology,1996,35:233-235.
[32] EDGE R,MCGARVEY D J,TRUSSCOTT T G.The carotenoids as antioxidants-a review[J].Journal of Photochemistry and Photobiology B: Biology,1997,41:189-200.
[33] 宋雁.类胡萝卜素抗氧化和促氧化作用的影响因素[J].卫生研究,2003,32(4):417-419.
[34] JURCZUK M,BRZOSKA M M,MONIUSZKO-JAKOIUK J.Hepatic and renal concentrations of vitamins E and Cin lead- and ethanol-exposed rats.An assessment of their involvement in the mechanisms of peroxidative damage[J].Food and Chemical Toxicology,2007,45(8):1478-1486.

[35] WAGNER B A,BUETTNER G R,BURNS C P.Vitamin E slows the rate of free radical-mediated lipid peroxidation in cells[J].Archives of Biochemistry and Biophysics,1996,334(2):261-267.

[36] BRENNAN L A,MORRIS G M,WASSON G R, et al.The effects of vitamin C or vitamin E supplementation on basal and H
2O
2-induced DNA damage in human lymphocytes[J].British Journal of Nutrition,2000,84(2):195-202.
[37] 汪求真,马爱国.维生素E对氧化应激及相关慢性病的影响[J].国外医学:卫生学分册,2008,35(6):364-370.
[38] WEINBERG R B,VANDERWERKEN B S,ANDERSON R A,et al.Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2001,21:1029-1033.
[39] EDER K K,FLAKER D,HIRCHE F,et al.Excess dietary vitamin E lowers the activation of antioxidative enzymes in erythrocytes of rats fed salmon oil[J].The Journal of Nutrition,2002,132(11):3400-3404.
[40] HAJIANI M,GOLESTANIO A,SHRIFTABRIZI A,et al.Dose-dependent modulation of systemic lipid peroxidation and activity of anti-oxidant enzymes by vitamin E in the rat[J].Redox Report,2008,13(2):60-66.

[41] ALBERTINI R,ABUJAP.Prooxidant and antioxidant properties of trolox C,analogue of vitamin E, in oxidation of low-density lipoprotein[J].Free Radical Research,1999,3:181-188.
[42] MILLER E R,PASTOR-BARRIUSO R, DALAL D,et al.Meta-analysis: high dosage vitamin E supplementation may increase all-cause mortality[J].Annals of Internal Medicine,2005,142:37-46.
[43] FUKUNAGA-TAKENAKA R,SHIRAI Y,YAGI K,et al.Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by
D-alpha-tocopherol[J].Genes Cells,2005,10:311-319.
[44] HUANG W C,CHEN P C,JOU S B,et al.Protein kinase C and changes in manganese suproxide dismutase gene expression in cultured glial cells[J].Clinical Experimental Pharmacology and Physiology,2001,28:822-825.
[45] PADAYATTY S J,KATZ A,WANG Y H,et al.Vitamin C as an antioxidant:evaluation of Its role in disease prevention[J].Journal of the American College of Nutrition,2003,22(1):18-35.
[46] 马爱国,刘四朝.不同剂量维生素C对DNA氧化损伤影响的研究[J].营养学报,2001,23(1):12-14.
[47] KAPSOKEFALOU M,MILLER D D.Iron loading and large doses of intravenous ascorbic acid promote lipid peroxidation in whole serum in guinea pigs[J].British Journal of Nutrition,2001,85:681-687.
[48] LACHILI B,HININGER I,FAURE H,et al.Increased lipid peroxidation in pregnant women after iron and vitamin C supplementation[J].Biological Trace Element Research,2001,83:103-110.
[49] COOKE M S,MISTRY N,AHMAD J,et al.Deoxycytidine glyoxal:lesion induction and evidence of repair following vitamin C supplementation in vivo[J].Free Radical Biology & Medicine,2003,34:218-225.
[50] CHEN W T,LIN Y F,YU F C,et al.Effect of ascorbic acid administration in hemodialysis patients on
in vitro oxidative stress parameters:influence of serum ferritin levels[J].American Journal of Kidney Disease,2003,42:158-166.
[51] BAILEY D M,RAMAN S,MCENERY J,et al.Vitamin C prophylaxis promotes oxidative lipid damage during surgical ischemia-reperfusion[J].Free Radical Biology and Medicine,2006,40:591-600.
[52] CHILDS A,JACOBS C,KAMINSKI T,et al.Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise[J].Free Radical Biology & Medicine,2001,31:745-753.
[53] HININGER I,WATERS R,OSMAN M,et al.Acute prooxidant effects of vitamin C in EDTA chelation therapy and long-term antioxidant benefits of therapy[J].Free Radical Biology & Medicine,2005,38:1565-1570.
[54] 崔乃杰,崔乃强,付强,等.抗坏血酸、抗氧化及促氧化双向作用的ESR研究 //第七届全国中西医结合普通外科临床及基础研究学术会议论文汇编.北京:中国中西医结合学会,2001:383-386.
[55] BUETTNER G R,JURKIEWICZ B A.Catalytic metals,ascorbate and free radicals:combinations to avoid[J].Radiation Research,1996,145:532-541.
[56] SARDI B.High-dose vitamin C and iron overlaod[J]. Annals of Internal Medicine,2004,140:846-847.
[57] BUSH A I.Metals and neuroscience[J].Current Opinion in Chemical Biology,2000,4(2):184-191.

[58] RIMBACH G,BOESCH-SAADATMANDI C,FRANK J,et al.Deietary isoflavones in the prevention of cardiovascular disease-a molecular perspective[J].Food Chemical Toxicology,2008,46(4):1308-1319.

[59] PETRA A T,THOMAS W.Benzo pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes-inhibition by plant polyphenols[J].Chemico-Biological Interactions,2007,169(1):25-31.

[60] 林映才,蒋宗勇,刘建中,等.大豆黄素对生长肥育猪的生产性能和血液免疫指标的影响[J].饲料博览,2001(6):4-6.
[61] JIANG Z Y,JIANG S W,LIN Y C. ,et al.Effects of soybean isoflavone on growth performance, meat quality and anti-oxidation in male broilers[J].Poultry Science,2007,86:1356-1362.
[62] KAMPKÖTTER A,TIMPEL C,RÖHRDANZE E,et al.Increased expression of catalase in human hepatoma cells by the soy isoflavone,Daidzein[J].Basic & Clinical Pharmacology Toxicology,2007,28:1176-1182.
[63] ARORA A,NAIR M G,STRASBURG G M.Antioxidant activities of isoflavones and their biological metabolites in a liposomal system[J].Archives of Biochemistry and Biophysics,1998,356:133-141.
[64] MIRA L,FERNANDEZ M T,SANTOS M,et al.Interactions of flavonoids with iron and copper ions:a mechanism for their antioxidant activity[J].Free Radical Research,2002,36(11):1199-1208.

[65] AGNIESZKA R,ANETA B,GRZEGORZ B.Antoxidative and prooxidative effects of quercetin on A549 cells[J].Cell Biology International,2007,34:1245-1250.
[66] FANG M Z,CHEN D P,YANG C S.Dietary polyphenols may affect DNA methylation[J].The Journal of Nutrition,2007,137:223-228.
[67] CANADA A,GIANNELLA E, NGUYEN T,et al.The production of reactive oxygen species by dietary flaonols[J].Free Radical Biological Medicine,1990,9:441-449.
[68] 许宗运.七种植物提取物对猪油的抗氧化性研究[J].塔里木农垦大学学报,2003,15(4):1-5.
[69] 朱宇旌,李新华,张勇,等.苜蓿黄酮抗氧化性研究[J].沈阳农业大学学报,2006,37(4):615-618.
[70] 程忠刚,林映才,余德谦,等.大豆异黄酮对肥育猪生产性能的影响极其作用机制探讨[J].动物营养学报,2005,17(1):30-34.
[71] LU J F,LI T,JIN D,et al.Preliminary study of dual characteristics of antioxidation and prooxidation of flavonoids[J].Journal of Chinical Pharmalogical Science,1999,8(1):15-20.
[72] GUO Q,RIMBACH G,MOINI H,et al.ESR and cell culture studies on free radical-scavenging and antioxidant activities of isoflavonoids[J].Toxicology,2002,179(1/2):171-180.
[73] GALATI G,SABZEVARI O,WILSON J X,et al.Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and others polyphenolics[J].Toxicology,2002,177:91-104.
[74] NORIYUKI K,POCAS E S,TOUZA N A,et al.Isoflavone decreases the free sulfydryl groups present in the enzyme and its inhibitory effect on enzyme activity[J].Bioorganic & Medicinal Chemistry,2008,16(19):8801-8805.

[75] CHOIA E J,CHEEA K M,LEEB B H.The prooxidant,rather than antioxidant,acts of daidzein
in vivo and
in vitro:daidzein suppresses glutathione metabolism[J].European Journal of Pharmacology,2006,542(3):162-169.

[76] SAHU S C,GRAY G C.Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei[J].Cancer Letters,1996,104(2):196-196.
[77] ASLAN M,OZBEN T.Oxidants in receptor tyrosine kinase signal transduction pathways[J].Antioxidants & Redox Signaling,2003,5(6):781-788.

[78] 田芳,仲伟鉴.α-硫辛酸的抗氧化和促氧化双向作用[J].环境与职业医学,2008,25(1):90-93.
[79] MORKUNAITE-HAIMI S,KRUGLOV A G,TEPLOVA V V,et al.Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate[J].Biochemical Pharmacology,2003,65:43-49.
[80] SARIS N E,KARJALAINEN A,TEPLOVAE V V,et al.Stimulation of the mitochondrial permeability transition by α-lipoate and dihydrolipoate[J].Biochemistry & Molecular Biology International,1998,44:127-134.
[81] BHATTI F,MANKHEY R W,ASICO L,et al.Mechanisms of antioxidant and pro-oxidant effects of α-lipoic acid in the diabetic and nondiabetic kidney[J].Kidney International,2005,67:1371-1380.
[82] ÇAKATAY UFUK.Pro-oxidant actions of α-lipoic acid and dihydrolipoic acid[J].Medical Hypotheses,2006,66:110-117.
[83] LINNANE A W,EASTWOOD H.Cellular redox poise modulation;the role of coenzyme Q,gene and metabolic regulation[J].Mitochondrion,2004,4:779-789.
[84] TIAN B,HUA Y J.Concentration-dependece of prooxidant and antioxidant effects of aloin and aloe-emodin on DNA[J].Food Chemistry,2005,91:413-418.
[85] LAMBERT J D,ELIAS R J.The antioxidant and pro-oxidant activities of green tea polyphenols:a role in cancer prevention[J].Archives Biochemistry and Biophysics,2010,501(1):65-72.

[86] WALLACE D C.Mitochondrial bioenergetics and reactive oxygen species in degenerative diseases and aging[M]//GUARENTE L P,PARTRIDGE L,WALLACE D C.Molecular Biology of Aging.Copenhagen:Cold Spring Harbor Laboratory Press,1999:125-147.
[87] MILLER E R,PASTOR-BARRIUSO R,DALAL D,et al.Meta-analysis:high dosage vitamin E supplementation may increase all-cause mortality[J].Annals of Internal Medicine,2005,142:37-46.