Effects of Betulinic Acid on Antioxidant Ability of Immune Organs in Mice

YI Jin; TU Di; WU Jing; YUAN Hui

doi:10.3969/j.issn.1006-267x.2012.04.025

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 4: 786 - 790

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.04.025

Effects of Betulinic Acid on Antioxidant Ability of Immune Organs in Mice

YI Jin ,
TU Di ,
WU Jing ,
YUAN Hui

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College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China

Received date: 2011-11-18

Online published: 2012-03-30

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Abstract

This experiment was conducted to investigate the effects of betulinic acid (BA) on antioxidant ability of immune organs in mice. A total of 28 KM mice were randomly divided into 4 groups with 7 mice in each group. The BA was administered once daily by gavage at dose levels of 0, 0.25, 0.50, and 1.00 mg per kg body weight for 14 days, and the BA was suspended in 0.2 mL of 1% soluble starch solution. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) content and total antioxidant capacity (T-AOC) of spleen and thymus in mice were determined at the end of the experiment. The results showed as follows: the activities of SOD and GSH-Px, and T-AOC of spleen and thymus were increased, while the MDA content of spleen and thymus was decreased by BA. Thereinto, the GSH-Px activity and T-AOC of spleen and thymus were significantly increased (P<0.05 or P<0.01), while the MDA content of spleen and thymus was significantly decreased at the dose of 0.50 mg BA per kg body weight (P<0.05 or P<0.01); the activities of SOD and GSH-Px, and T-AOC of spleen and thymus were significantly increased (P<0.05 or P<0.01), while the content of MDA was significantly decreased at the dose of 1.00 mg BA per kg body weight (P<0.01). Therefore, BA can effectively improve the antioxidant ability of immune organs in mice.

Key words： betulinic acid; mice; immune organs; antioxidant ability

Cite this article

YI Jin , TU Di , WU Jing , YUAN Hui . Effects of Betulinic Acid on Antioxidant Ability of Immune Organs in Mice[J]. Chinese Journal of Animal Nutrition, 2012 , 24(4) : 786 -790 . DOI: 10.3969/j.issn.1006-267x.2012.04.025

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