Iron Absorption and Its Regulation in the Neonate

SUN Xiaoming; WU Xin; YIN Yulong; SHU Xugang

doi:10.3969/j.issn.1006-267x.2012.06.002

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 6: 1001 - 1006

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.06.002

Iron Absorption and Its Regulation in the Neonate

SUN Xiaoming ,
WU Xin ,
YIN Yulong ,
SHU Xugang

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1. Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
2. Guangzhou Jiuyi Bio-Technology Co. , Ltd. , Guangzhou 510800, China

Received date: 2012-01-08

Online published: 2012-06-04

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Abstract

Maintaining iron homeostasis is important for mammal health, particularly in the rapidly growing period following birth. Iron deficiency not only decreases growth performance but also results in irreversible damage to central nervous system. However, the overload of iron during this period can also be detrimental, possibly due to excessive free radical production. However, neonates are unable to be down regulated in response to excess iron as it can be fine balanced in adults. So it is prudent to supplement neonates with iron as the immature regulation of iron absorption during early infancy. This article provides a succinct overview of current understanding of intestinal iron absorption and its regulation in the neonate.

Key words： iron homeostasis; neonate; absorption; iron overload; regulation

Cite this article

SUN Xiaoming , WU Xin , YIN Yulong , SHU Xugang . Iron Absorption and Its Regulation in the Neonate[J]. Chinese Journal of Animal Nutrition, 2012 , 24(6) : 1001 -1006 . DOI: 10.3969/j.issn.1006-267x.2012.06.002

References

[1] FRAZER D M,ANDERSON G J.Intestinal iron absorption and its regulation[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2005,289:G631-G635.
[2] DOMELLOF M.Iron requirements,absorption and metab-olism in infancy and childhood[J].Current Opinion in Clinical Nutrition & Metabolic Care,2007,10(3):329-335.
[3] COLLARD K J.Iron homeostasis in the neonate[J].Pediatrics,2009,123(4):1208-1216.
[4] 常彦忠,段相林,钱忠明.Hepc和铁稳态[J].中华内分泌代谢杂志,2003,19(6):501-504.
[5] FRAZER D M,DARSHAN D,ANDERSON G J.Intestinal iron absorption during suckling in mammals[J].BioMetals,2011,24(3):567-574.
[6] 张元贞.仔猪贫血及其防治[J].饲料研究,1989,5:26-27.
[7] 许丽,韩友文.甘氨酸螯合铁、蛋氨酸螯合铜预防仔猪贫血效果的研究[J].饲料工业,2001,22(11):38-39.
[8] 徐建雄,俞沛初,李家铨,等.母猪饲粮中添加蛋氨酸铁螯合物对预防仔猪贫血的影响[J].动物营养学报,1998,10(1):44-48.
[9] 何春红,王海霞,刘文博,等.洋姜治疗仔猪贫血的试验研究[J].中国畜牧兽医,2010,37(5):194-195.
[10] SHAYEGHI M,VULPE C D,MCKIE A T,et al.Identification of an intestinal heme transporter[J].Cell,2005,122:789-801.
[11] 郭佩,陈伟斌,张洁,等.小肠铁释放机制及相关疾病研究进展[J].生命科学,2008,20(4):651-656.
[12] KRAUSE A,NEITZ S,MAGERT H J,et al.LEAP2 1,a novel highly disul-fide-bonded human peptide,exhibits antimicr obial activity[J].FEBS Letters,2000,480(2/3):147-150.
[13] PARK C H,VALORE E V,WARING A J,et al.Hepc,a urinary anti-microbial peptide synthesized in the liver[J].The Journal of Biological Chemistry,2001,276:7806-7810.
[14] NICOLAS G,BENNOUN M,DEVAUX I,et al.Lack of Hepc gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockoutmice[J].Proceedings of the National Academy of Sciences of the United States of America,2001,98:8780-8785.
[15] ZHANG Z,FAN Z,PENG A,et al.Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses[J].Blood,2011(1):330-324.
[16] 袁粒星,高举,潘玲丽.肠道铁吸收及转运调节的研究进展[J].现代预防医学,2005,32(12):1652-1654.
[17] HENTZE M W,MUCKENTHALER M U,GALY B,et al.Two to tango:regulation of mammalian iron metabolism[J].Cell,2010,142(1):24-38.
[18] MITCHELL D K.Iron-sensing proteins that regulate Hepc and entiric iron absorption[J].Annual Review of Nutrition,2010,30:149-171.
[19] FRAZER D M,WILKINS S J,BECKER E M,et al.Hepc expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats[J].Gastroenterology,2002,123:835-844.
[20] DOMELLF M,COHEN R J,DEWEY K G,et al.Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age[J].Journal of Pediatrics,2001,138:679-687.
[21] DOMELLF M,LNNERDAL B,ABRAMS S A,et al.Iron absorption in breast-fed infants:effects of age,iron status,iron supplements,and complementary foods[J].The American Journal of Clinical Nutrition,2002,76:198-204.
[22] LEONG W I,BOWLUS C L,TALLKVIST J,et al.DMT1 and FPN1 expression during infancy:developmental regulation of iron absorption[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2003,285:G1153-G1161.
[23] LEONG W I,BOWLUS C L,TALLKVIST J,et al.Iron supplementation during infancy-effects on expression of iron transporters,iron absorption,and iron utilization in rat pups[J].The American Journal of Clinical Nutrition,2003,78:1203-1211.
[24] LIPINSKI P,STARZYNSKI R R,CANONNE H F,et al.Benefits and risks of iron supplementation inanemic neonatal pigs[J].The American Journal of Patbology,2010,177:1233-1243.
[25] FRAZER D M,WILKINS S J,ANDERSON G J.Elevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tract[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2007,293(3):G525-G531.
[26] HANSEN S L,TRAKOOLJUL N,SPEARS J W,et al.Age and dietary iron affect expression of genes involved in iron acquisition and homeostasis in yong pigs[J].The Journal of Nutrition,2010,140:271-277.
[27] SHANNON B L,KELLEHER L.Iron metabolism in infants and children[J].Food and Nutrition Bulletin,2007,28(4):S491-S499.
[28] 刘宝娟,张文兵.铁蛋白的结构、功能及表达调控[J].饲料工业,2009,30(4):42-47.
[29] DEWEY K G,DOMELLF M,COHEN R J,et al.Iron supplementation affects growth and morbidity of breast-fed infants:results of a randomized trial in Sweden and Honduras[J].The Journal of Nutrition,2002,132:3249-3255.
[30] FREDRIKSSON A,SCHRODER N,ERIKSSON P,et al.Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice[J].Toxicology and Applied Pharmacology,1999,159:25-30.
[31] LAO T T,LOONG E P,CHIN R K H,et al.Relationship between newborn and maternal iron status and haematological indices[J].Biology of the Neonate,1991,60(5):303-307.

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