This experiment was conducted to investigate the effects of threonine supplementation on growth performance and intestinal health of weaner piglets challenged with Pseudorabies virus (PRV). A total of 30 healthy DLY weaner piglets with an average body weight of (6.94?1.26) kg were used in this experiment. A 3?2 factorial design was used. Dietary true ileal digestible threonine (TIDT) levels were 0.74%, 0.89% and 1.11%, respectively. Piglets were injected with live swine PRV or sterilized saline water. The injection was carried out on day 8, and the whole experiment lasted for 21 days. The results showed that the injection of PRV significantly increased serum PRV-specific antibody level (P<0.01), which showed that stress pattern had been successfully established. Under immune stress condition challenged by PRV, the feed:gain ratio (F/G) of piglets at 1 to 21 days (P<0.10) and 7 to 21 days of the experiment (P<0.05) and the crypt depth in jejunum of piglets (P<0.01) were increased. The ratio of villus height to crypt depth in jejunum of piglets was significantly decreased (P<0.01) in such an immune stress condition and pathological changes such as degeneration, necrosis and exfoliation occurred in duodenal mucosal epithelium of the villus. As the dietary TIDT level increased, the villus height in duodenum of piglets experienced an upward trends (P<0.10). Threonine supplementation, to a certain extent, could affect the feed:gain ratio of piglets at 1 to 21 days and 7 to 21 days of the experiment (P<0.10). At the same time, there was a significant interaction between dietary TIDT level and immune stress on the ratio of villus height to crypt depth in duodenum (P<0.05), and the pathological changes which were induced by PRV could be alleviated at a relative high dietary TIDT level. In conclusion, supplementation of dietary threonine, to a certain extent, can improve growth performance and alleviate intestinal injury which is induced by PRV injection.
LAI Xiang
,
MAO Xiangbing
,
YU Bing
,
HAN Guoquan
,
HE Jun
,
HUANG Zhiqing
,
ZHENG Ping
,
YU Jie
,
CHEN Daiwen
. Effects of Threonine Supplementation on Growth Performance and Intestinal Health of Weaner Piglets Challenged with Pseudorabies Virus[J]. Chinese Journal of Animal Nutrition, 2012
, 24(9)
: 1647
-1655
.
DOI: 10.3969/j.issn.1006-267x.2012.09.006
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