This experiment was conducted to study the effects of adding β-hydroxy-β-methylbutyrate (HMB) to sow diets on reproductive performance of sows and growth performance of piglets and their immune function. Twenty crossbred pregnant sows (Landrace×Large White) were randomly allotted by parity and expected delivery date into 2 groups with 10 replicates of 1 sow. Control group was fed a basal diet, and experimental group was fed the basal diet supplemented with 2 000 mg/kg HMB. The experiment was from day 74 of gestation to day 21 after parturition. The results showed that with addition of 2 000 mg/kg HMB to late gestation and lactation sow diets, compared with the control group, birth weight of piglets born alive was increased by 14.1% (P<0.05), litter body weight at 7 and 21 days of age was increased by 16.6% and 11.7% (P<0.05), and litter body weight gain from birth to 7 days of age and from birth to 21 days of age was increased by 28.3% and 12.5% (P<0.05). On day 98 of gestation and the day of parturition, compared with the control group, the serum immunoglobulin G (IgG) content of sows was increased by 35.3% (P<0.01) and 13.0% (P>0.05), and the serum immunoglobulin M (IgM) content was increased by 34.7% (P<0.05) and 12.6% (P>0.05). Compared with the control group, colostrum IgG content was increased by 19% (P<0.05), and milk IgM content on day 14 after parturition was increased by 21.4% (P<0.05). Compared with the control group, plasma IgG and IgM contents of piglets at 7 days of age were increased by 11.4% and 40.1% (P<0.05). It is concluded that 2 000 mg/kg HMB can enhance body weight at birth and body weight gain during suckling periods of piglets, and improve immune function of sows and their suckling piglets.
LI Yongming
,
XU Ziwei
,
LIU Jie
,
FENG Shanglian
. Effects of Adding β-Hydroxy-β-Methylbutyrate to Sow Diets on Reproductive Performance of Sows and Growth Performance of Piglets and Their Immune Function[J]. Chinese Journal of Animal Nutrition, 2012
, 24(9)
: 1745
-1753
.
DOI: 10.3969/j.issn.1006-267x.2012.09.018
[1] VAN DE LIGT J L G,LINDEMANN M D,HARMON R J,et al.Effect of chromium tripicolinate supplementation on porcine immune response during the periparturient and neonatal period[J].Journal of Animal Science,2002,80(2):456-466.
[2] CZECH A,GRELA E R,MOKRZYCKA A,et al.Efficacy of mannanoligosaccharides additive to sows diets on colostrum,blood immunoglobulin content and production parameters of piglets[J].Polish Journal of Veterinary Sciences,2010,13(3):525-531.
[3] 张荣庆,韩正康,陈杰,等.大豆黄酮对母猪免疫功能和血清及初乳中GH、PRL、SS水平的影响[J].动物学报,1995,41(2):201-206.
[4] CORINO C,PASTORELLI G,ROSI F,et al.Effect of dietary conjugated linoleic acid supplementation in sows on performance and immunoglobulin concentration in piglets[J].Journal of Animal Science,2009,87(7):2299-2305.
[5] 田春庄,肖成林,黄飞若,等.β-CD-半胱胺对母猪繁殖性能和仔猪生长性能的影响[J].动物营养学报,2007,19(5):559-566.
[6] 乔璇,张海军,齐广海,等.β-羟基-β-丁酸甲酯调控肌肉代谢的研究进展[J].动物营养学报,2011,23(12):2064-2070.
[7] NISSEN S,FULLER J C,Jr,SELL J,et al.The effect of beta-hydroxy-beta-methylbutyrate on growth,mortality,and carcass qualities of broiler chickens[J].Poultry Science,1994,73(1):137-155.
[8] PETERSON A L,QURESHI M A,FERKET P R,et al.In vitro exposure with β-hydroxy-β-methylbutyrate enhances chicken macrophage growth and function[J].Veterinary Immunology and Immunopathology,1999,67(1):67-78.
[9] SIWICKI A K,FULLER J C,Jr,NISSEN S,et al.In vitro effects of β-hydroxy-β-methylbutyrate(HMB) on cell-mediated immunity in fish[J].Veterinary Immunology and Immunopathology,2000,76(3/4):191-197.
[10] SIWICKI A K,MORAND M,FULLER J C,Jr,et al.Influence of HMB (β-hydroxy-β-methylbutyrate) on antibody secreting cells (ASC) after in vitro and in vivo immunization with the anti-Yersinia ruckeri vaccine of rainbow trout (Oncorhynchus mykiss)[J].Veterinary Research,2001,32(5):491-498.
[11] SIWICKI A K,ZAKC S ' Z,FULLER J C,Jr,et al.Influence of β-hydroxy-β-methylbutyrate on nonspecific humoral defense mechanisms and protection against furunculosis in pikeperch (Sander lucioperca)[J].Aquaculture Research,2006,37(2):127-131.
[12] NISSEN S,FAIDLEY T D,ZIMMERMAN D R,et al.Colostral milk fat percentage and pig performance are enhanced by feeding the leucine metabolite beta-hydroxy-beta-methyl butyrate to sows[J].Journal of Animal Science,1994,72(9):2331-2337.
[13] KRAKOWSKI L,KRZYZANOWSKI J,WRONA Z,et al.The influence of nonspecific immunostimulation of pregnant sows on the immunological value of colostrum[J].Veterinary Immunology and Immunopathology,2002,87(1/2):89-95.
[14] TATARA M R,SLIWA E,KRUPSKI W.Prenatal programming of skeletal development in the offspring:effects of maternal treatment with beta-hydroxy-beta-methylbutyrate (HMB) on femur properties in pigs at slaughter age[J].Bone,2007,40(6):1615-1622.
[15] 郭万正.规模养猪实用技术[M].北京:金盾出版社,2010:65.
[16] GERLINGER-ROMERO F,GUIMARÃES-FERREIRA L,GIANNOCCO G,et al.Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMB) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats[J].Growth Hormone & IGF Research,2011,21(2):57-62.
[17] TATARA M R.Neonatal programming of skeletal development in sheep is mediated by somatotrophic axis function[J].Experimental Physiology,2008,93(6):763-772.
[18] STERLE J A,CANTLEY T C,LAMBERSON W R,et al.Effects of recombinant porcine somatotropin on placental size,fetal growth,and IGF-Ⅰ and IGF-Ⅱ concentrations in pigs[J].Journal of Animal Science,1995,73(10):2980-2985.
[19] BUYSE J,SWENNEN Q,VANDEMAELE F,et al.Dietary β-hydroxy-β-methylbutyrate supplementation influences performance differently after immunization in broiler chickens[J].Journal of Animal Physiology and Animal Nutrition,2009,93(4):512-519.
[20] 郭俊清.亮氨酸及β-羟基-β-甲基丁酸钙对绒山羊免疫机能和生产性能影响的研究.硕士学位论文.呼和浩特:内蒙古农业大学,2009:36-54.
[21] PETERSON A L,QURESHI M A,FERKET P R,et al.Enhancement of cellular and humoral immunity in young broilers by the dietary supplementation of beta-hydroxy-beta-methylbutyrate[J].Immunopharmacology and Immunotoxicology,1999,21(2):307-330.
[22] MARTINSSON K.Mammary secretion of IgG in sows[J].Acta Veterinaria Scandinavica,1972,13(2):191-196.
[23] BOURNE F J,CURTIS J.The transfer of immunoglobins IgG,IgA and IgM from serum to colostrum and milk in the sow[J].Immunology,1973,24(1):157-162.
[24] VAN KOEVERING M,NISSEN S.Oxidation of leucine and α-ketoisocaproate to β-hydroxy-β-methylbutyrate in vivo[J].American Journal of Physiology:Endocrinology and Metabolism,1992,262(1):E27-E31.