Secretory Immunoglobulin A:Relationship with Intestinal Mucosal Immunity and Nutritional Regulation of Its Secretion

WANG Dingyue; XU Shengyu; SONG Jie; YANG Shuangyuan; WU De

doi:10.3969/j.issn.1006-267x.2012.10.002

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 10: 1854 - 1860

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.10.002

Review

Secretory Immunoglobulin A:Relationship with Intestinal Mucosal Immunity and Nutritional Regulation of Its Secretion

WANG Dingyue ,
XU Shengyu ,
SONG Jie ,
YANG Shuangyuan ,
WU De

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Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratary of Animal Disease-Resistance Nutrition of Sichuan Province, Ya'an 625014, China

Received date: 2012-04-24

Online published: 2012-09-29

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Abstract

Secretory immunoglobulin A (SIgA) is composed by dimeric IgA which connected by J chain and secretory component (SC). SIgA antibodies have some important physiological functions in intestinal mucosal immunity such as maintaining stabilization of intestinal mucosal homeostasis, regulating endogenous microecology, blocking pathogen attachment to epithelial cell receptors and directly decreasing bacterial virulence and immune exclusion, thus inhibiting the spread of pathogens and further infection. Under the condition of pathogens or stress, nutritional factors such as fatty acids, amino acids and vitamins might significantly promote the secretion of intestinal SIgA, increase the body's resistance ability to pathogens, and improve the performance of the animals.

Key words： secretory immunoglobulin A; intestinal tract; mucosal immune; nutrition

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WANG Dingyue , XU Shengyu , SONG Jie , YANG Shuangyuan , WU De . Secretory Immunoglobulin A:Relationship with Intestinal Mucosal Immunity and Nutritional Regulation of Its Secretion[J]. Chinese Journal of Animal Nutrition, 2012 , 24(10) : 1854 -1860 . DOI: 10.3969/j.issn.1006-267x.2012.10.002

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