Effects of Dietary Acanthopanax senticosus Polysaccharide on Immune Parameters in Blood of Weaner Piglets

HAN Jie; BIAN Lianquan; LIU Xianjun; ZHANG Fei; YANG Kankan

doi:10.3969/j.issn.1006-267x.2012.12.019

Chinese Journal of Animal Nutrition >

2012 , Vol. 24 >Issue 12: 2444 - 2449

DOI: https://doi.org/10.3969/j.issn.1006-267x.2012.12.019

Feed Science and Technology

Effects of Dietary Acanthopanax senticosus Polysaccharide on Immune Parameters in Blood of Weaner Piglets

HAN Jie ,
BIAN Lianquan ,
LIU Xianjun ,
ZHANG Fei ,
YANG Kankan

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1. College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang 110866, China;
2. Department of Life Science, Luoyang Normal University, Luoyang 471022, China;
3. Breeding Pigs Field for Scientific Research, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2012-06-11

Online published: 2012-12-03

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Abstract

This experiment was conducted to investigate the effects of dietary Acanthopanax senticosus polysaccharide (ASPS) on blood immune parameters of weaner piglets. This experiment was a 21-d growth assay, in which 96 'Landrac×Yorkshire’ crossbred weaner piglets aged (28±3) days were randomly allotted to 6 dietary treatments supplemented with 0, 150, 300, 500, 800 and 1 000 mg/kg of ASPS, respectively. Each treatment was replicated in 4 pens containing 4 pigs per pen. The results showed that compared with the control, diets supplemented with ASPS did not significantly affect the number of red blood cell (RBC) and neutrophil in peripheral blood, the content of IL-4 and the antibody levels of IgG, IgA and IgM in serum (P＞0.05), but significantly increased the number of white blood cell (WBC) and lymphocyte in peripheral blood and the contents of IL-2 and IFN-γ in serum (P＜0.05). With the increase of dietary ASPS supplemental level, the number of WBC (P＜0.01) and lymphocyte in peripheral blood (P＜0.01), and serum IL-2 (P＜0.05) and IFN-γ contents (P＜0.01) were increased quadratically. The effects of dietary ASPS on the number of WBC and lymphocyte in peripheral blood and the contents of IL-2 and IFN-γ in serum had a dose-dependent relationship, 500 to 1 000 mg/kg ASPS significantly affected them (P＜0.05 or P＜0.01) except that serum IL-2 content was only affected by 800 mg/kg ASPS (P＜0.05), while the effects were not significant when the supplemental level was less than 500 mg/kg (P＞0.05). The results indicate that the number of WBC and lymphocyte in peripheral blood, and the contents of IL-2 and IFN-γ in serum are improved in a dose-dependent manner, and as a consequence, ASPS can enhance immunological function of weaner piglets.

Key words： Acanthopanax senticosus polysaccharide; weaner piglets; immune function; cytokines

Cite this article

HAN Jie , BIAN Lianquan , LIU Xianjun , ZHANG Fei , YANG Kankan . Effects of Dietary Acanthopanax senticosus Polysaccharide on Immune Parameters in Blood of Weaner Piglets[J]. Chinese Journal of Animal Nutrition, 2012 , 24(12) : 2444 -2449 . DOI: 10.3969/j.issn.1006-267x.2012.12.019

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