Review

The Relationship between Cytochrome CYP3A4 in Vivo and the Toxicity of Aflatoxin B1 in Feedstuffs

  • ZHENG Lili ,
  • ZHU Yujing ,
  • SHAO Caimei ,
  • ZHANG Yong
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  • 1. School of Animal Science and Veterinary, Shenyang Agricultural University, Shenyang 110866, China;
    2. Liaoning Wellhope Agri-Tech Co., Ltd., Shenyang 110164, China

Received date: 2012-07-02

  Online published: 2013-01-04

Abstract

Aflatoxin B1 (AFB1) is one of the metabolites of aflatoxin, which mainly affects the antioxidant systems and the immune systems in vivo as the main pathogenic carcinogenic substances in an organism. AFB1 metabolism was mainly found in animal liver, and the cytochrome P450 (CYP450s) in liver microsomal involved in a variety of drug and toxicant metabolism. Cytochrome CYP3A4 (CYP3A4) involved in the metabolism of AFB1 as the isozyme of CYP450 in the liver. AFB1 ingested by an animal combines with DNA and RNA and produces toxic effects, and another part of AFB1 metabolizes with glutathione peroxidase and glutathione S-transferase enzymes and then goes into blood and urine, which acts as detoxification effect. Adding antioxidants in feeds has a positive effect on relieving AFB1 toxicity. Another way to study AFB1 damage is to add some natural or chemical ingredients in feeds to act as the inhibition of CYP3A4 in the liver, which will provide a new approach to the development of feed additives.

Key words: CYP3A4; AFB1; antioxidants

Cite this article

ZHENG Lili , ZHU Yujing , SHAO Caimei , ZHANG Yong . The Relationship between Cytochrome CYP3A4 in Vivo and the Toxicity of Aflatoxin B1 in Feedstuffs[J]. Chinese Journal of Animal Nutrition, 2013 , 25(1) : 13 -20 . DOI: 10.3969/j.issn.1006-267x.2013.01.003

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