[1] HENTZE M W,MUCHKENTHALER M U,ANDREWS N C.Balancing acts:molecular control of mammalian iron metabolism[J].Cell,2004,117(3):285-297.
[2] ANDREW N C.Medical progress:disorders of iron metabolism[J].New England Journal of Medicine,1999,41(12):1986-1995.
[3] GRIFFITHS E.Iron in biological systems[M]//BULLEN J J,GRIFFITHS E.Iron and infection.Chichester:Wiley Press,1999:1-26.
[4] KORTMAN G A M,BOLEIJ A,SWINKELS D W,et al.Iron availability increases the pathogenic potential of
Salmonella typhimurium and other enteric pathogens at the intestinal epithelial interface[J].PLoS One,2012,7(1):e29968.doi:10.1371/journal.pone.0029968.
[5] FOSTER S L,RICHARDSON S H,FAILLA M L.Elevated iron status increase bacterial invasion and surevival and alters cytokine/chemokine mRNA expression in Caco-2 human intestinal cells[J].The Journal of Nutrition,2001,131(5):1452-1458.
[6] WESSLING-RESNICK M.Iron homeostasis and the inflammatory response[J].Annual Review of Nutrition,2010,30(4):105-122.
[7] GUNSHIN H,MACKENZIE B,BERGER U V,et al.Cloning and characterization of a mammalian proton coupled metal-ion transporter[J].Nature,1997,388(6641):482-488.
[8] CONRAD M E,UMBREIT J N.Iron absorption and transport-an update[J].American Journal of Haematology,2000,64(4):287-298.
[9] VULPE C D,KUO Y,MURHY T L,et al.Hephaestin, a ceruloplasmi homologue implicated in intestinal iron transport,is defective in the sla mouse[J].Nature Genetics,1999,21(2):195-199.
[10] DONOVAN A,BROWNLIE A,ZHOU Y,et al.Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrae iron exporter[J].Nature,2000,403(6771):776-781.
[11] BAI S P,LU L,LUO X G,et al.Kinetic of manganese absorption in ligated small intestinal segments of broilers[J].Poultry Science,2008,87(12):2596-2604.[JP+1]
[12] FRAZER D M,WILKINS S J,BECKER E M,et al.A rapid decrease in the expression of DMT1 and Dcytb but not Ireg 1 or hephaestin explains the mucosal block phenomena of iron absorption[J].Gut,2003,52(3):340-346.
[13] HAN O,WESSLING-RESNICK M.Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2002,282(3):G527-G533.[JP+1]
[14] SINGH B,ARORA S,AGRAWAL P,et al.Hepcidin:a novel peptide hormone regulating iron metabolism[J].Clinica Chimica Acta,2011,412(11/12):823-830.[JP+1]
[15] KAWABATA H,YANG R,IRAMA T,et al.Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family[J].Journal of Biological Chemistry,1999,274(30):20826-20832.
[16] MASARATANA P,LAFTAH A H,LATUNDE-DADA G O,et al.Iron absorption in hepcidin1 knockout mice[J].British Journal of Nutrition,2011,105(11):1583-1591.
[17] GEWIRTZ A T,MADARA J L.Periscope,up!Monitoring microbes in the intestine[J].Nature Immunology,2001,2(4):288-290.
[18] VASQUEZ-TORRES A,FANG F C.Cellular routes of invasion by enteropathogens[J].Current Opinion in Microbiology,2000,3(1):54-59.
[19] GUMBINER B.Structure,biochemistry,and assembly of epithelial tight junctions[J].American Journal of Physiology,1987,253(6 Pt 1):C749-C758.
[20] BURKEY T E,SKJOLAAS-WILSON K,MINTON J E.Expression of porcine toll-like receptors 2,4 and 9 in response to lipopolysaccharide and
Salmonella enterica serovars
Typhimurium and
Choleraesuis[J].Veterinary Immunology and Immunopathology,2009,130(1/2):96-101.
[21] NEUTRA M R,MANTIS N J,KRAEHENBUHL J P.Collaboration of epithelial cells with organized mucosal lymphoid tissues[J].Nature Immunology,2001,2(11):1004-1009.
[22] DIDIERLAURENT A,SIRAD J C,KRAEHENBUHL J P,et al.How the gut senses its content[J].Cell Microbiology,2002,4(2):61-72.
[23] AKIRA S,TAKEDA K.Toll-like receptor signaling[J].Nature Reviews Immunology,2004,4(7):499-511.
[24] GHOSH S,MAY M J,KOPP E B.Nf-kappa B and Rel proteins:evolutionarily conserved mediateors of immune responses[J].Annual Review Immunology,1998,16:225-260.
[25] SKJOLAAS K A,BURKEY T E,DRITZ S S,et al.Effects of
Salmonella enterica serovars
Typhimurium and
Choleraesusis on chemokine and cytokine expression in swine ileum and jejunal epithelial cells[J].Veterinary Immunology and Immunopathology,2006,111(3/4):119-209.
[26] MEANS T K,HAYASHI F,SMITH K D,et al.The toll-like recetpor 5 stimulus bacterial flagell in induces maturation and chemokine production in human dendritic cells[J].Journal of Immunology,2003,170(10):5165-5175.
[27] TAKEDA K,AKIRA S.Toll receptors and pathogen resistance[J].Cell Micobiology,2003,5(3):143-153.
[28] MAASER C,KAGOFF M F.Role of the intestinal epithelium in orchestrating innate and adaptive mucosal immunity[J].Gastroenterology,2002,40(7):525-529.
[29] KIRBY A C,YIRLID U,WICK M J.The innate immune response differs in primary and secondary
Salmonella infection[J].Journal of Immunology,2002,169(8):4450-4459.
[30] MILLAR A D,RAMPTON D S,BLAKE D R.Effects of iron and iron chelation
in vitro on mucosal oxidant activity in ulcerative colitis[J].Alimentary Pharmacology & Therapeutics,2000,14(9):1163-1168.
[31] BERGERON R J,WIEGAND J,WEIMAR W R,et al.Prevention of acetic acid-induced colitis by desferrithiocin analogs in a rat model[J].Digestive Diseases and Sciences,2003,48(2):399-407.
[32] SERIL D N,LIAO J,HO K L,et al.Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice[J].Digestive Diseases and Sciences,2002,47(6):1266-1278.
[33] WILSON A,REYES E,OFMAN J.Prevalence and outcomes of anemia in inflammatory bowel disease:a systematic review of the literature[J].American Journal of Medicine,2004,116(Suppl.7A):44S-49S.
[34] BYRD T F,HORWITZ M A.Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular mulitplication of
Legionella pneumophila by limiting the availability of iron[J].Journal of Clinical Investigation,1989,83(5):1457-1465.
[35] YEH K Y,YEH M,GLASS J.Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2004,286(3):G385-G394.[JP+1]
[36] PEPPERCORN M A.Is there a role for antibiotics as primary therapy in Crohn’s ileitis?[J].Journal of Clinical Gastroenterology,1993,17(3):235-237.
[37] NICOLAS G,BENNOUN M,DEVAUX I,et al.Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice[J].Proceedings of the National Academy of Sciences of the United States of America,2001,98(15):8780-8785.
[38] BURPEE T,MITCHELL P,FISHMAN D,et al.Intestinal ferroportin expression in pediatric Crohn’s disease[J].Inflammatory Bowel Diseases,2011,17(2):524-531.
[39] NEMETH F,RIVERA S,GABAYAN V,et al.IL-6 mediates hypoferremia of inflammation by inducting the synthersis of the iron regulatory hormone hepcidin[J].Journal of Clinical Investigation,2004,113(9):1271-1276.
[40] YANG F,LIU X B,QUINONES M,et al.Regulation of reticuloendothelial iron transporter MTP1 by inflammation[J].Journal of Biological Chemistry,2002,277:39786-39791.
[41] JOHNSON E E,SANDGREN A,CHERAYIL B J,et al.Role of ferroportin in macrophage-mediated immunity[J].Infection and Immunity,2010,78(12):5099-5106.
