Effects of Complex Polypeptide on Growth Performance, Blood Physiological and Chemical Parameters and Intestinal Main Microbial Flora Number in Early-Weaner Piglets

GU Juan; XU Congcong; CAI Xuan; YANG Shoufeng; QI Liang; XU Jianxiong

doi:10.3969/j.issn.1006-267x.2013.03.016

2013 , Vol. 25 >Issue 3: 579 - 586

DOI: https://doi.org/10.3969/j.issn.1006-267x.2013.03.016

Feed Science and Technology

Effects of Complex Polypeptide on Growth Performance, Blood Physiological and Chemical Parameters and Intestinal Main Microbial Flora Number in Early-Weaner Piglets

GU Juan ,
XU Congcong ,
CAI Xuan ,
YANG Shoufeng ,
QI Liang ,
XU Jianxiong

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1. School of Agriculture and Biology, Shanghai Jiao Tong University, Key Laboratory for Veterinary and Biotechnology, Shanghai 200240, China;
2. Shanghai Go-Try Biotechnology Company, Shanghai 201404, China

Received date: 2012-09-12

Online published: 2013-02-28

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Abstract

This study was to investigate the effects of complex polypeptide on growth performance, physiological and chemical parameters in blood and intestinal main microbial flora unmber in early-weaner piglets. Ninety 21-day-old weaner piglets with similar average body weight were randomly allocated to 3 groups with 3 replicates per group and 10 piglets per replicate. The control group was fed a basal diet and the experimental groups were fed the basal diets supplemented with 0.5% and 1.0% complex polypeptide, respectively. The experiment period was 30 days. The results showed as follows: compared with the control group, the supplementation of 0.5% and 1.0% complex polypeptide could improve average daily gain and average daily feed intake, and decrease feed/gain in the experiment period (P>0.05). The supplementation of 0.5% complex polypeptide significantly increased the total antioxidant capacity (P<0.05), and the supplementation of 1.0% complex polypeptide significantly decreased the content of nitric oxide in serum (P<0.05). Addition of 0.5% and 1.0% complex polypeptide could increase serum immune indices to different extents, and the supplementation of 1.0% complex polypeptide significantly increased the contents of interleukin-2, thyroxine, insulin and gastrin in serum (P<0.05). The supplementation of 0.5% complex polypeptide significantly increased the number of Lactobacillus and significantly decreased the number of Escherichia coli in intestinal tract (P<0.05). In conclusion, supplementation of 0.5% and 1.0% complex polypeptide in diets improves growth performance, antioxidant ability, immune indices and hormone indices in serum, and the supplementation of 0.5% complex polypeptide increases the number of Lactobacillus and decreases the number of Escherichia coli in intestinal tract.

Key words： complex polypeptide; early-weaner piglets; growth performance; intestinal microbial flora

Cite this article

GU Juan , XU Congcong , CAI Xuan , YANG Shoufeng , QI Liang , XU Jianxiong . Effects of Complex Polypeptide on Growth Performance, Blood Physiological and Chemical Parameters and Intestinal Main Microbial Flora Number in Early-Weaner Piglets[J]. Chinese Journal of Animal Nutrition, 2013 , 25(3) : 579 -586 . DOI: 10.3969/j.issn.1006-267x.2013.03.016

References

[1] 汪莉,苏军.应激与现代养猪生产[J].家畜生态,2000,2(14):27-32.
[2] 刘影,朱文涛,张博,等.微生态制剂替代抗生素对生长肥育猪生长性能的影响[J].饲料工业,2010,31(14):30-33.
[3] 魏华光,穆小梅,黄汉军.八菌宝微生态制剂对仔猪免疫功能试验研究[J].畜牧兽医杂志,2003,22(5):6-7.
[5] 陈小波,田允波,葛长荣,等.中草药添加剂对生长肥育猪免疫功能的影响研究[J].云南农业大学学报,2002,17(2):176-179.
[6] YIMIT D,HOXUR P,AMAT N,et al.Effects of soybean peptide on immune function,brain function,and neurochemistry in healthy volunteers[J].Nutrition,2011,28(2):154-159.
[7] 国明明,华欲飞.大豆肽免疫调节作用的研究[J].食品科技,2007(7):242-244.
[8] CLARE D A,SWAISGOOD H E.Biocative milk peptides:a prospectus[J].Journal of Dairy Science,2000,83(6):1187-1195.

[9] 张源淑,邓艳,宋晓丹,等.酪啡肽及其酪蛋白水解肽对早期断奶仔猪分泌型免疫球蛋白A和细胞因子水平的影响[J].动物营养学报,2008,20(2):196-199.
[10] 王莹,李文丽,马忠明.多肽的固相合成方法研究[J].安徽农业科学,2006,34(22):5768-5770.
[11] 许丛丛,陈小连,朱丽慧,等.复合抗氧化剂对早期断奶仔猪肠道主要菌群的影响[J].饲料研究,2012(4):4-8.
[12] 王淑彩,许梓荣.免疫促进胸腺肽的研究紧张[J].畜牧与兽医,2002,34(10):39-41.
[13] 余斌,傅伟龙.饲粮添加胸腺肽对肉鸡增重、免疫及内分泌的影响[J].华南农业大学学报,1997,18:6-11.
[14] 单安山,马得莹,冯兴军,等.抗菌肽的功能、研发与应用[J].中国农业科学,2012,45(11):2249-2259.
[15] ALEXANDRA K M,WILLIAM J G,ROBERT E W.Antibacterial peptides for therapeutic use:obstacles and realistic outlook[J].Current Opinion in Pharmacology,2006,6(5):468-472.

[16] 温刘发,张常明.抗菌肽代替抗生素在断奶仔猪饲粮中的应用效果[J].中国饲料,2001(18):13-14.
[17] 刘莉如,杨开伦,滑静,等.抗菌肽对蛋用仔公鸡生长性能、免疫指标及空肠组织相关细胞因子基因mRNA表达的影响[J].动物营养学报,2012,24(7):1345-1351.
[18] LEICHTLING K D,SERRATE S A,SZTEIN M B.Thymosin alpha1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes[J].International Journal of Immunopharmacology,1990,12(1):19-29.

[19] BOMAN H G.Peptide antibiotics and their role in innate immunity[J].Annual Review of Immunology,1995,13:61-92.
[20] LANGERHOLC T,MARAGKOUDAKIS P A,WOLLGAST J,et al.Novel and established intestinal cell line models-an indispensable tool in food science and nutrition[J].Trends in Food Science and Technology,2011,22:S11-S20.
[21] SCOTT T,ZIJPP A,GLICK B.Effect of thiouracil-induced hypothyroidism on the humoral immunity of new Hampshire chickens[J].Poultry Science,1985,64:2211-2217.
[22] HADDAD E E,MASHALY M M.Effect of thyrotropin-releasing hormone,triiodothyronine,and chicken production hormone on plasma concentration of lymphoid organs and leukocyte the population in immature male chickens[J].Poultry Science,1990,69(7):1094-1102.

[23] CANH T T,SUTTON A L,AARNINK A J,et al.Dietary carbohydrates alter the fecal composition and pH and the ammonia emission from slurry of growing pigs[J].Journal of Animal Science,1998,76(7):1887-1895.
[24] MATHEW A G,SUTTON A L,SCHEIDT A B,et al.Effect of galactan on selected microbial populations in the ileum of the weaning pig[J].Journal of Animal Science,1993,71(6):1503-1509.

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