Effects of Acanthopanax senticosus Polysaccharide on Growth Performance and Blood Physiology and Biochemistry Indexes of Weaner Piglets Challenged with Lipopolysaccharide

HAN Jie; BIAN Lianquan; ZHANG Yiran; LIU Xianjun; ZHANG Fei

doi:10.3969/j.issn.1006-267x.2013.05.021

2013 , Vol. 25 >Issue 5: 1054 - 1061

DOI: https://doi.org/10.3969/j.issn.1006-267x.2013.05.021

Feed Science and Technology

Effects of Acanthopanax senticosus Polysaccharide on Growth Performance and Blood Physiology and Biochemistry Indexes of Weaner Piglets Challenged with Lipopolysaccharide

HAN Jie ,
BIAN Lianquan ,
ZHANG Yiran ,
LIU Xianjun ,
ZHANG Fei

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1. College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang 110866, China;
2. Department of Life Science, Luoyang Normal University, Luoyang 471022, China;
3. Breeding Pigs Field for Scientific Research, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2012-11-28

Online published: 2013-04-12

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Abstract

This experiment was conducted to evaluate the effects of dietary Acanthopanax senticosus polysaccharide (ASPS) on growth performance and blood physiology and biochemistry indexes of weaner piglets challenged with lipopolysaccharide (LPS). The experiment was a 2×2 factorial design with two factors: diet (supplementation with ASPS or not) and immunological challenge (LPS or normal saline injection). A total of 64 crossbred barrows (Duroc×Large White×Landrace), aged (28±3) days, with an initial weight of (7.22±0.46) kg were randomly allotted to 4 treatments, treatments 1 and 2 were fed a basal diet with 0 mg/kg ASPS, and treatments 3 and 4 were fed the basal diet with 800 mg/kg ASPS. On days 14 and 21, pigs in treatments 2 and 4 were given an intraperitoneal injection with 100 μg/kg BW of LPS, and pigs in the other treatments were given equivalent amount of normal saline. Blood samples were obtained at 3 h after injection to analyze blood physiology and biochemistry parameters. The experiment lasted for 21 days. The results showed as follows: on days 1 to 14, ASPS supplementation had no significant effect on growth performance of piglets without LPS challenge (P>0.05). On days 15 to 21, ASPS supplementation significantly increased average daily gain (ADG) and average daily feed intake (ADFI) of piglets (P<0.05), and there was a significant interaction between ASPS supplementation and LPS challenge on the effect of ADG (P<0.05). ASPS supplementation significantly increased ADG and ADFI in LPS challenged piglets (P<0.05), but did not in normal saline-injected piglets (P>0.05). On day 14, ASPS supplementation significantly increased the number of peripheral blood lymphocytes (P<0.05), and it had significant interaction with LPS challenge (P<0.05). ASPS supplementation significantly increased the number of peripheral blood lymphocytes in LPS challenged piglets (P<0.05), but did not in normal saline-injected piglets (P>0.05). On days 14 and 21, ASPS supplementation significantly reduced the plasma contents of α-acid glycoprotein (α-AGP), glucose and prostaglandin (PGE₂) (P<0.05) as well as significantly increased the content of interleukin-2 (IL-2) of piglets (P<0.05). ASPS supplementation significantly reduced the plasma contents of α-AGP, glucose and PGE₂ in LPS challenged piglets (P<0.05), but did not in normal saline-injected piglets (P>0.05). The results indicate that ASPS supplementation can alleviate growth-depression of immunological challenge weaner piglets by depressed contents of α-AGP, PGE₂ as well as increase IL-2 content in plasma and the number of peripheral blood lymphocytes, but has no effect on growth performance in normal weaner piglets.

Key words： Acanthopanax senticosus polysaccharide; weaner piglets; lipopolysaccharide; growth performance; immune challenge

Cite this article

HAN Jie , BIAN Lianquan , ZHANG Yiran , LIU Xianjun , ZHANG Fei . Effects of Acanthopanax senticosus Polysaccharide on Growth Performance and Blood Physiology and Biochemistry Indexes of Weaner Piglets Challenged with Lipopolysaccharide[J]. Chinese Journal of Animal Nutrition, 2013 , 25(5) : 1054 -1061 . DOI: 10.3969/j.issn.1006-267x.2013.05.021

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