Review

Ornithine Decarboxylase Antizyme 1: Molecular Characterization and Functions

  • MA Rong ,
  • KANG Bo ,
  • JIANG Dongmei ,
  • HE Hui
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  • College of Animal Science and Technology, Sichuan Agricultural University, Ya’an 625014, China

Received date: 2013-01-07

  Online published: 2013-06-17

Abstract

The synthesis of ornithine decarboxylase antizyme 1 (OAZ1) protein is mediated by a mechanism involving a programmed +1 frameshifting during translation of the OAZ1 full-length mRNA. The studies suggest that OAZ1 could bind to ornithine decarboxylase (ODC) and facilitate its degradation, resulting in decreasing the polyamine level in cells; OAZ1 also could bind to cell cycle regulatory proteins including Cyclin D1, Cyclin E1 and Smad1, and then result in blocking the cell cycle. Furthermore, recent studies showed that OAZ1 acted as a tumor suppressor and played an important role in regulating the process of animal reproduction. Furthermore, antizyme inhibitor has a higher affinity for OAZ1 than for ODC, and as such can displace ODC from the ODC-OAZ1 complex and prevent ODC from being degraded. Asparagine can effectively inhibit OAZ1 expression and regulate the ODC activity. In this paper, the research progress in molecular characterization and functions of OAZ1 were reviewed.

Cite this article

MA Rong , KANG Bo , JIANG Dongmei , HE Hui . Ornithine Decarboxylase Antizyme 1: Molecular Characterization and Functions[J]. Chinese Journal of Animal Nutrition, 2013 , 25(7) : 1453 -1458 . DOI: 10.3969/j.issn.1006-267x.2013.07.008

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