XU Youqing , LI Weifeng , DING Zhaokun . Synergism of Glutamine and Vitamin E on Animals: Effects and Mechanisms[J]. Chinese Journal of Animal Nutrition, 2013 , 25(8) : 1671 -1676 . DOI: 10.3969/j.issn.1006-267x.2013.08.002

[1] LI H T,FENG L,JIANG W D,et al.Oxidative stress parameters and anti-apoptotic response to hydroxyl radicals in fish erythrocytes:protective effects of glutamine,alanine,citrulline and proline[J].Aquatic Toxicology,2013,126:169-179.

[2] RAUT A M,SURYAKAR A N,MHAISEKAR D.Study of glutathione metabolism,oxidative stress and the effect of vitamin e supplementation in chronic obstructive pulmonary disease (copd)[J].International Journal of Biomedical Research,2012,3(7):322-326.

[3] SCHUSTER H,BLANC M C,BONNEFONT-ROUSSELOT D,et al.Protective effects of glutamine dipeptide and α-tocopherol against ischemia-reperfusion injury in the isolated rat liver[J].Clinical Nutrition,2009,28(3):331-337.  

[4] CHENG Z,GATLIN D M,BUENTELLO A.Dietary supplementation of arginine and/or glutamine influences growth performance,immune responses and intestinal morphology of hybrid striped bass (Morone chrysops×Morone saxatilis)[J].Aquaculture,2012,362:39-43.

[5] POHLENZ C,BUENTELLO A,BAKKE A M,et al.Free dietary glutamine improves intestinal morphology and increases enterocyte migration rates,but has limited effects on plasma amino acid profile and growth performance of channel catfish Ictalurus punctatus[J].Aquaculture,2012,370:32-39.

[6] GAO J,KOSHIO S,ISHIKAWA M,et al.Effects of dietary oxidized fish oil with vitamin E supplementation on growth performance and reduction of lipid peroxidation in tissues and blood of red sea bream Pagrus major[J].Aquaculture,2012,356:73-79.

[7] JIANG J,ZHENG T,ZHOU X Q,et al.Influence of glutamine and vitamin E on growth and antioxidant capacity of fish enterocytes[J].Aquaculture Nutrition,2009,15(4):409-414.  

[8] EL-SHEIKH N M,KHALIL F A.L-arginine and L-glutamine as immunonutrients and modulating agents for oxidative stress and toxicity induced by sodium nitrite in rats[J].Food and Chemical Toxicology,2011,49(4):758-762.  

[9] 许友卿,李伟峰,丁兆坤.谷氨酰胺对水生动物免疫的影响及机理[J].动物营养学报,2012,24(3):406-410.

[10] JACOBS H,MOALIN M,BAST A,et al.An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network[J].PLoS One,2010,5(11):1-9.

[11] KATZ A,BROBERG S,SAHLIN K,et al.Muscle anmlonia and amino acid metabolism during dynamic exercise:in man[J].Clinical Physiology,1986,6(4):365-379.  

[12] 马宏霞.L-谷氨酰胺与维生素E联合给药对游泳力竭大鼠抗氧化和运动后免疫功能的影响[J].中国老年学杂志,2007,27(16):1565-1567.

[13] GUPTA A,SINGH S,JAMAL F,et al.Synergistic effects of glutathione and vitamin E on ROS mediated ethanol toxicity in isolated rat hepatocytes[J].Asian Journal of Biochemistry,2011,6(4):347-356.  

[14] NATTAKOM T V,CHARLTON A,WILMORE D W.Use of vitamin E and glutamine in the successful treatment of severe ven-occlusive disease following bone marrow transplantation[J].Nutrition in Clinical Practice,1995,10(1):16-18.  

[15] GORINGE A P,BROWN S,O’CALLAGHAN U,et al.Glutamine and vitamin E in the treatment of hepatic veno-occlusive disease following high-dose chemotherapy[J].Bone Marrow Transplantation,1998,21(8):829-832.  

[16] SAKAMOTO M I,MURAKAMI A E,SILVEIRA T G V,et al.Influence of glutamine and vitamin E on the performance and the immune responses of broiler chickens[J].Brazilian Journal of Poultry Science,2006,8(4):243-249.

[17] MURAKAMI A E,SAKAMOTO M I,NATALI M R,et al.Supplementation of glutamine and vitamin E on the morphometry of the intestinal mucosa in broiler chickens[J].Poultry Science,2007,86(3):488-495.

[18] 王立媛,程爱国,张小平.谷氨酰胺、精氨酸、维生素E和β-胡萝卜素联合应用对饥饿大鼠肠屏障功能的保护作用[J].中国普通外科杂志,2008,17(2):183-185.

[19] 李金敏.谷氨酰胺对慢性冷应激雏鸡肝脏损伤的影响 .硕士学位论文.哈尔滨:东北农业大学,2009.

[20] 李士泽,李玲,高福久,等.谷氨酰胺和L-肉碱对低温下肉羊抗氧化性能的影响[J].中国畜牧杂志,2012,48(7):43-46.

[21] VENDITTI P,DI STEFANO L,DI MEO S.Vitamin E reduces cold-induced oxidative stress in rat skeletal muscle decreasing mitochondrial H₂O₂ release and tissue susceptibility to oxidants[J].Redox Report,2009,14(4):167-175.  

[22] FERRARO V,CRUZ I B,JORGE R F,et al.Valorisation of natural extracts from marine source focused on marine by-products:a review[J].Food Research International,2010,43(9):2221-2233.  

[23] LEYGONIE C,BRITZ T J,HOFFMAN L C.Impact of freezing and thawing on the quality of meat:review[J].Meat Science,2012,91(2):93-98.  

[24] ASHADEVI S,MANJULA K R,SUBRAMANYAM M V V.Protective role of vitamins E and C against oxidative stress caused by intermittent cold exposure in aging rat’s frontoparietal cortex[J].Neuroscience Letters,2012,529(2):155-160.  

[25] PAULA D A J,ANDRADE E S,MURGAS L D S,et al.Vitamin E and reduced glutathione in Prochilodus lineatus (Curimba) semen cryopreservation (Characiformes:Prochilodontidae)[J].Neotropical Ichthyology,2012,10(3):661-665.  

[26] ANEL-LPEZ L,LVAREZ-RODRGUEZ M,GARCA-LVAREZ O,et al.Reduced glutathione and Trolox (vitamin E) as extender supplements in cryopreservation of red deer epididymal spermatozoa[J].Animal Reproduction Science,2012,135(1/2/3/4):37-46.

[27] TAPPEL A L.Selenium-glutathione peroxidase and vitamin E[J].The American Journal of Clinical Nutrition,1974,27(9):960-965.

[28] 许友卿,李文龙,丁兆坤.添加剂维生素E对鱼类的抗氧化作用剂其机理[J].饲料工业,2010,31(18):6-10.

[29] HAMRE K,MOLLAN T A,SLE ,et al.Rotifers enriched with iodine and selenium increase survival in Atlantic cod (Gadus morhua) larvae[J].Aquaculture,2008,284(1/2/3/4):190-195.

[30] SUN Z H,HE Z X,ZHANG Q L,et al.Effects of protein and/or energy restriction for six weeks on antioxidation capacity of plasma and gastrointestinal epithelial tissues of weaned kids[J].Livestock Science,2012,149(3):232-241.  

[31] TSAI P H,LIU J J,YEH C L,et al.Effects of glutamine supplementation on oxidative stress-related gene expression and antioxidant properties in rats with streptozotocin -induced type 2 diabetes[J].British Journal of Nutrition,2012,107(8):1112-1118.  

[32] HAMRE K,WAAGB R,BERGE R K,et al.Vitamins C and E interact in juvenile Atlantic salmon (Salmo salar L.)[J].Free Radical Biology and Medicine,1997,22(1/2):137-149.

[33] BOSE K S C,VYAS P,SINGH M.Plasma non-enzymatic antioxidants-vitamin C,E,β-carotenes,reduced glutathione levels and total antioxidant activity in oral sub mucous fibrosis[J].European Review for Medical and Pharmacological Sciences,2012,16(4):530-532.

[34] PFLUGMACHER S,WIEGAND C,OBEREMM A,et al.Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin LR:the first step in detoxification[J].Biochimica et Biophysica Acta,1998,1425(3):527-533.  

[35] 刘佃辛,顾景范.维生素E在生物膜中的作用[J].生理科学进展,1993,24(1):83-86.

[36] 许友卿,黄金华,姜洁,等.柠檬酸和维生素E对鱼类的影响及机理研究进展[J].中国农学通报,2012,28(32):94-99.

[37] LIN Y,ZHOU X Q.Dietary glutamine supplementation improves structure and function of intestine of juvenile Jian carp (Cyprinus carpio var.Jian)[J].Aquaculture,2006,256(1/2/3/4):389-394.

[38] 张洪斌.谷胱甘肽和维生素E、C与自由基[J].新疆师范大学学报,1999,9(18):79-81.

[39] AZZI A,STOCKER A.Vitamin E:non-antioxidant roles[J].Progress in Lipid Research,2000,39(3):231-255.  

[40] LUO M,BAZARGAN N,GRIFFITH D P,et al.Metabolic effects of enteral versus parenteral alanyl-glutamine dipeptide administration in critically ill patients receiving enteral feeding:a pilot study[J].Clinical Nutrition,2008,27(2):297-306.  

[41] SCHWIMMER J B,EE L,ZHENG S,et al.Glutamine promotes triglyceride absorption in a dose-dependent manner[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2002,282(2):G317-G323.