[1] CEREIJIDO M,CONTRERAS R G,SHOSHANI L,et al.Tight junction and polarity interaction in the transporting epithelial phenotype[J].Biochimica et Biophysica Acta:Biomembranes,2008,1778(3):770-793.
[2] WALSH S V,HOPKINS A M,CHEN J,et al.Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia[J].Gastroenterology,2001,121(3):566-579.
[3] UTECH M,IYANOV A I,SAMARIN S N,et al.Mechanism of IFN-γ-induced endocytosis of tight junction proteins:myosin Ⅱ-dependent vacuolarization of the apical plasma membrane[J].Molecular Biology of the Cell,2005,16(10):5040-5052.
[4] TERRY S,NIE M,MATTER K,et al.Rho signaling and tight junction functions[J].American Physiological Society,2010,25(1):16-26.
[5] RUSS P K,PINO C J,WILLIAMS C S,et al.Bves modulates tight junction associated signaling[J].PLoS One,2011,6(1):e14563.
[6] MATTER K,BALDA M S.Signalling to and from tight junctions[J].Nature Reviews Molecular Cell Biology,2003,4(3):225-237.
[7] PARIS L,TONUTTI L,VANNINI C,et al.Structural organization of the tight junctions[J].Biochimica et Biophysica Acta:Biomembranes,2008,1778(3):646-659.
[8] DÖRFEL M J,HUBER O.Modulation of tight junction structure and function by kinases and phosphatases targeting occludin[J].Journal of Biomedicine and Biotechnology,2012,2012:807356.
[9] ANGELOW S,AHLSTROM R,YU A S L.Biology of claudins[J].American Journal of Physiology:Renal Physiology,2008,295(4):F867-F876.
[10] HARTSOCK A,NELSON W J.Adherens and tight junctions:structure,function and connections to the actin cytoskeleton[J].Biochimica et Biophysica Acta:Biomembranes,2008,1778(3):660-669.
[11] AIJAZ S,BALDA M S,MATTER K.Tight junctions:molecular architecture and function[J].International Review of Cytology,2006,248:261-298.
[12] HOU J H,RENIGUNTA A,KONRAD M,et al.Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex[J].The Journal of Clinical Investigation,2008,118(2):619-628.
[13] ADACHI M,INOKO A,HATA M,et al.Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3,a tight-junction MAGUK protein[J].Molecular and Cellular Biology,2006,26(23):9003-9015.
[14] LEUNG L W,CONTRERAS R G,FLORES-MALDONADO C,et al.Inhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cells[J].American Journal of Physiology:Cell Physiology,2003,284(4):C1021-C1030.
[15] NAKAO T,KURITA N,KOMATSU M,et al.Irinotecan injures tight junction and causes bacterial translocation in rat[J].Journal of Surgical Research,2012,173:341-347.
[16] SCHNEEBERGER E E,LYNCH R D.The tight junction:a multifunctional complex[J].American Journal of Physiology:Cell Physiology,2004,286(6):C1213-C1228.
[17] LAFFAFIAN I,HALLETT M B.Lipid-protein cargo transfer:a mode of direct cell-to-cell communication for lipids and their associated proteins[J].Journal of Cellular Physiology,2007,210(2):336-342.
[18] COLEMAN M L,MARSHALL C J,OLSON M F.RAS and RHO GTPases in G1-phase cell-cycle regulation[J].Nature Reviews Molecular Cell Biology,2004,5(5):355-366.
[19] ETIENNE-MANNEVILLE S,HALL A.Rho GTPases in cell biology[J].Nature,2002,420:629-635.
[20] BERNARDS A,SETTLEMAN J.GAPs in growth factor signaling[J].Growth Factors,2005,23(2):143-149.
[21] GARCÍA-MATA R,BURRIDGE K.Catching a GEF by its tail[J].Trends in Cell Biology,2007,17(1):36-43.
[22] BRUEWER M,HOPKINS A M,HOBERT M E,et al.RhoA,Rac1,and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin[J].American Journal of Physiology:Cell Physiology,2004,287(2):C327-C335.
[23] GOPALAKRISHNAN S,RAMAN N,ATKINSON S J,et al.Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion[J].American Journal of Physiology:Cell Physiology,1998,275:C798-C809.
[24] BIRUKOVA A A,ADYSHEV D,GORSHKOV B,et al.GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction[J].American Journal of Physiology:Lung Cellular and Molecular Physiology,2006,290:L540-L548.
[25] LI B,ZHAO W D,TAN Z M,et al.Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells[J].FEBS Letters,2006,580(17):4252-4260.
[26] BOGATCHEVA N V,ADYSHEV D,MAMBETSARIEV B,et al.Involvement of microtubules,p38,and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction[J].American Journal of Physiology:Lung Cellular and Molecular Physiology,2007,292:L487-L499.
[27] FUJITA H,KATOH H,HASEGAWA H,et al.Molecular decipherment of Rho effector pathways regulating tight-junction permeability[J].Biochemical Journal,2000,346:617-622.
[28] IVANOV A I,BACHAR M,BABBIN B A,et al.A unique role for nonmuscle myosin heavy chain ⅡA in regulation of epithelial apical junctions[J].PLoS One,2007,2(8):e658.
[29] MA T Y,BOIVIN M A,YE D M,et al.Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier:role of myosin light-chain kinase protein expression[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2005,288:G422-G430.
[30] SHEN L,BLACK E D,WITKOWSKI E D,et al.Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure[J].Journal of Cell Science,2006,119:2095-2106.
[31] MCKENZIE J A G,RIDLEY A J.Roles of RhoROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeability[J].Journal of Cellular Physiology,2007,213:221-228.
[32] GAVARD J,PATEL V,GUTKIND J S.Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia[J].Developmental Cell,2008,14(1):25-36.
[33] BERNARD O.Lim kinases,regulators of actin dynamics[J].The International Journal of Biochemistry & Cell Biology,2007,39(6):1071-1076.
[34] NAGUMO Y,HAN J,BELLILA A,et al.Cofilin mediates tight-junction opening by redistributing actin and tight-junction proteins[J].Biochemical and Biophysical Research Communications,2008,377(3):921-925.
[35] MIYAZAKI T,HONDA K,OHATA H.m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions[J].Cardiovascular Research,2010,85(3):530-541.
[36] GOPALAKRISHNAN S,RAMAN N,ATKINSON S J,et al.Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion[J].American Journal of Physiology:Cell Physiology,1998,275:C798-C809.
[37] HIRASE T,KAWASHIMA S,WONG E Y M,et al.Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and-independent mechanisms[J].The Journal of Biological Chemistry,2001,276(13):10423-10431.
