Molecular Mechanisms of Feed Intake Regulation through Integration of Various Peripheral Signals by Central Nervous System

ZHENG Liufeng; PENG Jian

doi:10.3969/j.issn.1006-267x.2013.10.004

2013 , Vol. 25 >Issue 10: 2212 - 2221

DOI: https://doi.org/10.3969/j.issn.1006-267x.2013.10.004

Review

Molecular Mechanisms of Feed Intake Regulation through Integration of Various Peripheral Signals by Central Nervous System

ZHENG Liufeng ,
PENG Jian

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College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Received date: 2013-04-03

Online published: 2013-09-16

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Abstract

Feed intake is the cornerstone of assuring adequate production performance of animals and a variety of environmental stimuli influences the feed intake. Numerous peripheral stimuli involved gastrointestinal peptides, adiposity signaling molecules (insulin and leptin), and nutrients signal to central nervous system (CNS) have an important physiological role in regulating feed intake. CNS plays the central role in feed intake regulation, while the molecular pathway and mechanism has been increasingly recognized for the past few years. In mammals, it has already identified some key CNS intracellular signal transduction pathways and transcription factors as sensors/integrators in regulating feed intake, such as some highly conserved key pathways—the hypothalamic mammalian target of rapamycin (mTOR) and general control nonderepressible-2 kinase (GCN2)-mediated general amino acid control (GAAC) pathway, and transcription factors involved forkhead transcription factor 1 (FoxO1) and signal transducer and activator of transcription 3 (STAT3). This review provided an overview of the research progress of physiological and CNS molecular mechanisms in the overall control of feed intake.

Key words： feed intake; regulation mechanisms; central nervous system; signal pathway; mTOR; GCN2

Cite this article

ZHENG Liufeng , PENG Jian . Molecular Mechanisms of Feed Intake Regulation through Integration of Various Peripheral Signals by Central Nervous System[J]. Chinese Journal of Animal Nutrition, 2013 , 25(10) : 2212 -2221 . DOI: 10.3969/j.issn.1006-267x.2013.10.004

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