Mechanism of Transient Receptor Potential 2 Mediating Animal Oxidative Stress and Its Nutrition Regulation

MA Sicong; LI Lei; LI Haiyan; AO Yunyang; TANG Zhiru

doi:10.3969/j.issn.1006-267x.2013.10.006

Chinese Journal of Animal Nutrition >

2013 , Vol. 25 >Issue 10: 2231 - 2237

DOI: https://doi.org/10.3969/j.issn.1006-267x.2013.10.006

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Mechanism of Transient Receptor Potential 2 Mediating Animal Oxidative Stress and Its Nutrition Regulation

MA Sicong ,
LI Lei ,
LI Haiyan ,
AO Yunyang ,
TANG Zhiru

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1. Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400716, China;
2. Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, College of Animal Science and Technology, Southwest University, Chongqing 400716, China

Received date: 2013-04-24

Online published: 2013-09-16

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Abstract

Transient receptor potential 2 (TRPM2) can be activated by adenosine diphosphoribose and reactive oxygen species, and is a kind of protein with dual functions of both ion channel and adenosine diphosphate ribose hydrolase. With high permeability to Ca²⁺, the channel also acts as an endogenous redox sensor for mediating oxidative stress, and induces subsequent specific Ca²⁺-dependent cellular reactions, such as endothelial hyper-permeability and apoptosis. This article mainly reviewed TRPM2 feature, the mechanism of TRPM2 mediating animal oxidative stress and the regulation of nutrients on TRPM2 channel mediating animal oxidative stress.

Key words： transient receptor potential 2; oxidative stress; nutrients

Cite this article

MA Sicong , LI Lei , LI Haiyan , AO Yunyang , TANG Zhiru . Mechanism of Transient Receptor Potential 2 Mediating Animal Oxidative Stress and Its Nutrition Regulation[J]. Chinese Journal of Animal Nutrition, 2013 , 25(10) : 2231 -2237 . DOI: 10.3969/j.issn.1006-267x.2013.10.006

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