Review

Oxidative Stress and DNA Injury

  • RAN Maoliang ,
  • GAO Huan ,
  • YIN Jie ,
  • CHEN Bin
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  • 1. College of Animal Science & Technology, Hunan Agriculture University, Changsha 410128, China;
    2. Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock and Poultry, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    3. University of the Chinese Academy of Sciences, Beijing 10008, China

Received date: 2013-04-03

  Online published: 2013-09-16

Abstract

After challenged by intra-and extracellular environmental factors, such as nitric oxide, calcium and pathogenic organisms, the balance between oxidative and antioxidant defense systems in human and animal cells is broken, which results in the accumulation of reactive oxygen species (ROS) within cells, and finally oxidative stress occurs. Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes; meanwhile, when challenged by physical or chemical factors, such as depurination and apyrimidinic factors, X-ray, ultraviolet, alkylating agent and intercalator, DNA also could be injured, furthermore, DNA damage is a source to oxidative stress in body. This paper mainly reviewed oxidative stress, DNA damage, and their relationship, which could provide a theoretical basis for a further research.

Cite this article

RAN Maoliang , GAO Huan , YIN Jie , CHEN Bin . Oxidative Stress and DNA Injury[J]. Chinese Journal of Animal Nutrition, 2013 , 25(10) : 2238 -2245 . DOI: 10.3969/j.issn.1006-267x.2013.10.007

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