This experiment was conducted to determine the amino acid standardized ileal digestibility of cottonseed meals from different areas of China and establish the predicating models of amino acid standardized ileal digestibility of cottonseed meals through analyzing the chemical composition of cottonseed meals. Twelve crossed-bred swine (Duroc×Landrace×Yorkshine) with an average body weight of 40 kg were randomly assigned to two Latin square design treatments with 6 swine per treatment, and each treatment included five cottonseed meal diets and a N-free diet. Each Latin square treatment had Ⅰ to Ⅵ periods, each period lasted for seven days, the first five days were pre-feeding period, and the final two days were sample collection period. The T-type fistula method was used to determinate the amino acid standardized ileal digestibility of cottonseed meals. The results showed as follows: the mean range of essential amino acid standardized ileal digestibility of cottonseed meals was from 69.42% to 94.50%, and the essential amino acid standardized ileal digestibility was Lys 74.63%, Met 69.42%, Trp 77.95%, Thr 81.43%, Val 83.26%, Ile 81.97%, Leu 84.65%, Phe 89.97%, His 87.89% and Arg 94.50%. According to the different areas, the mean range of essential amino acid standardized ileal digestibility of cottonseed meal from Yangtze River basin was from 65.02% to 95.96%, that from Yellow River basin was from 68.02% to 93.15%, and that from Inland northwest was from 74.70% to 95.76%. The predicating models for amino acid standardized ileal digestibility were as follows: SLys=-63.372+2.783×CP (R²=0.499, RSD=5.119, P<0.05); SMet=98.861-1.623×CF (R²=0.402, RSD=5.274, P<0.05); STrp=48.863-0.031×FG+1.001×CP (R²=0.707, RSD=2.492, P<0.05); SThr=114.937-0.050×FG (R²=0.449, RSD =5.443, P<0.05). The results indicate that the amino acid standardized ileal digestibility of cottonseed meals is different. Most essential amino acid standardized ileal digestibility of cottonseed meals from Yangtze River basin is the highest among the three ares, and the Inland northwest is better than Yellow River basin. The predicating models for amino acid standardized ileal digestibility are established according to the chemical composition of cottonseed meals.