Review

Nutrition Physiological and Immune Functions of Arginine in Animals

  • SUN Hongnuan ,
  • YANG Haiming ,
  • WANG Zhiyue ,
  • ZHANG Decai ,
  • ZHANG Fenfen ,
  • YANG Zhi
Expand
  • College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2013-08-07

  Online published: 2013-12-24

Abstract

Arginine not only participates in anabolism and catabolism of various nutrients in the body, but also can regulate the immunity system by means of arginase and nitric oxide metabolic pathways as a immune regulator. This article reviewed the physico-chemical properties, anabolism and catabolism, nutrition physiological and immune functions of arginine.

Cite this article

SUN Hongnuan , YANG Haiming , WANG Zhiyue , ZHANG Decai , ZHANG Fenfen , YANG Zhi . Nutrition Physiological and Immune Functions of Arginine in Animals[J]. Chinese Journal of Animal Nutrition, 2014 , 26(1) : 54 -62 . DOI: 10.3969/j.issn.1006-267x.2014.01.008

References

[1] GENG M M, LI T J, KONG X F, et al.Reduced expression of intestinal N-acetylglutamate synthase in sucling piglets:a novel molecular mechanism for arginine as a nutritionally essential amino acid for neonates[J].Amino Acids, 2011, 40(5):1513-1522.  

[2] TAMIR H, RATNER S.Enzymes of arginine metabolism in chicks[J].Archives of Biochemistry and Biophysics, 1963, 102(2):249-258.  

[3] WU G Y, JAEGER L A, BAZER F W, et al.Arginine deficiency in preterm infants:biochemical mechanisms andnutritional implications[J].The Journal of Nutritional Biochemistry, 2004, 15(8):442-451.  

[4] EFRON D, BARBUL A.Role of arginine in immunonutrition[J].Journal of Gastroenterology, 2000, 35(Suppl.12):20-23.

[5] WANG W W, QIAO S Y, LI D F.Amino acids and gut function[J].Amino Acids, 2009, 37(1):105-110.  

[6] LI P, KIM S W, LI X, et al.Dietary supplementation wit cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs[J].Nitric Oxide, 2008, 19(3):259-265.  

[7] WU G Y, BAZER F W, DAVIS T A, et al.Important roles for the arginine family of amino acids in swine nutrition and production[J].Livestock Science, 2007, 112(1/2):8-22.

[8] LIGTHART-MELIS G C, VAN DE POLL M C G, BOELENS P G, et al.Glutamine is an important precursor for de novo synthesis of arginine in humans[J].American Society for Clinical Nutrition, 2008, 87(5):1282-1289.

[9] ROGERS Q R, FREEDLAND R A, SYMMONS R A.In vivo synthesis and utilization of arginine in the rat[J].American Journal of Physiology, 1972, 223(1):236-240.

[10] SZEPESI B, AVER E H, FREEDLAND R A, et al.Role of kidney in luconeogenesis and amino acid excretion[J].American Journal of Physiology, 1970, 219:1627-1631.

[11] BLACHIER F, M'RABET-TOUIL H, POSHO L, et al.Intestinal arginine metabolism during development[J].European Journal of Biochemistry, 1993, 216(1):109-117.  

[12] 石现瑞, 王恬.家禽体内精氨酸功能研究进展[J].中国饲料, 2003(4):12-14.

[13] LABELLE W C, MILLER D S, LERNER J, et al.Interactions between leucine and arginine transport in chicken small intestine[J].Biochemical and Biophysical Research Communications, 1971, 45(1):131-137.  

[14] CLOSS E I, SIMON A, VÉKONY N, et al.Plasma membrane transporters for arginine[J].The Journal of Nutrition, 2004, 134(Suppl.10):2752-2759.

[15] BALL R O, URSCHEL K L, PENCHARZ P B.Nutritional consequences of interspecies differences in arginine and lysine metabolism[J].The Journal of Nutrition, 2007, 137(Suppl.2):1626S-1641S.

[16] MORRIS S M, Jr.Arginine metabolism:boundaries of our knowledge[J].The Journal of Nutrition, 2007, 137(Suppl.2):1602S-1609S.

[17] NIEVES C Jr, ANGKAMP-HENKEN B.Arginine and immunity:a unique perspective[J].Biomedicine Pharmacotherrapy, 2002, 56(10):471-482.  

[18] GOBERT A P, DAULOUEDE S, LEPOIVRE M, et al.L-aginine availability modulates local nitric oxide production and parasite illing inn experimental trypanosomiasis[J].Infection and Immunity, 2000, 68(8):4653-4657.  

[19] 麻名文, 李福昌.日粮精氨酸水平对断奶-2月龄肉兔生长性能、免疫器官指数及血清指标的影响[J].动物营养学报, 2009, 21(3):405-410.

[20] CORZO A, MORAN E T, Jr, HOEHLER D.Arginine need of heavy broiler males applying the ideal protein concept[J].Poultry Science, 2003, 82(3):402-407.

[21] 刘凤菊, 呙于明, 王磊.1-3周龄雌性肉仔鸡精氨酸需要量[J].动物营养学报, 2011, 23(4):571-577.

[22] 方勇军.精氨酸对肉鸭生长性能、免疫机能、胴体品质和血液脂质的影响[D].硕士学位论文.武汉:武汉工业学院, 2009:19-21.

[23] 朱伟, 姜威, 李新杰, 等.精氨酸对夏季旱养肉鸭生长性能和免疫器官的影响[J].粮食与饲料工业, 2013(1):49-52.

[24] 姚康, 褚武英, 邓敦, 等.不同精氨酸添加水平对哺乳仔猪生长性能的影响[J].天然产物研究与开发, 2008, 20(1):121-124.

[25] YAO K, YIN Y L, CHU W Y, et al.Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs[J].The Journal of Nutrion, 2008, 138(5):867-872.

[26] KIM S W, MCPHERSON R L, WU G Y.Dietary arginine supplementation enhances the growth of milk-fed young pigs[J].The Journal of Nutrition, 2004, 134(3):625-630.

[27] 范苗.添加不同水平的精氨酸对新生仔猪生长性能、免疫性能及胃肠道发育的影响[D].硕士学位论文.保定:河北农业大学, 2011:15.

[28] 杨慧, 林伯全, 张力, 等.L-精氨酸和乳酸菌对早期断奶仔猪生长性能、血液生化指标和小肠黏膜形态的影响[J].福建农林大学学报:自然科学版, 2012, 41(4):514-519.

[29] 孔祥峰, 印遇龙, 伍国耀.猪功能性氨基酸营养研究进展[J].动物营养学报, 2009, 21(1):1-7.

[30] TAN B E, YIN Y L, LIU Z Q, et al.Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs[J].Amino Acids, 2009, 37(1):169-175.  

[31] TAN B E, YIN Y L, LIU Z Q, et al.Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle[J].The Journal of Nutritional Biochemistry, 2011, 22(5):441-445.  

[32] 吴琛, 刘俊锋, 孔祥峰, 等.饲粮精氨酸与丙氨酸对环江香猪肉质、氨基酸组成及抗氧化功能的影响[J].动物营养学报, 2012, 24(3):528-533.

[33] TURNER P, DEAR J, SCADDING G, et al.Role of kinins in seasonal allergic rhinitis:icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen[J].Journal of Allergy and Clinical Immunology, 2001, 107(1):105-113.  

[34] YAO K, GUAN S, LI T J, et al.Dietary L-arginine supplementation enhances intestinal development and expression of vascular endothelial growth factor in weanling piglets[J].British Journal of Nutrition, 2011, 105(5):703-709.  

[35] WU X, RUAN Z, GAO Y L, et al.Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn-and soybean meal-based diet[J].Amino Acids, 2010, 39(3):831-839.  

[36] PUIMAN P J, STOLL B, VAN GOUDOEVER J B, et al.Enteral arginine does not increase superior mesenteric arterial blood flow but induces mucosal growth in neonatal pigs[J].The Journal of Nutrition, 2011, 141(1):63-70.  

[37] 孟国权, 刘玉兰, 车政权, 等.L-精氨酸对脂多糖诱导的断奶仔猪肠道黏膜屏障损伤的缓解作用[J].动物营养学报, 2010, 22(3):647-652.

[38] LIU Y L, HAN J, HUANG J J, et al.Dietary L-arginine supplementation improves intestinal function in weaned pigs after an Escherichia coli lipopolysaccharide challenge[J].Asian-Australasian Journal of Animal Sciences, 2009, 22(12):1667-1675.

[39] 郭长义, 蒋宗勇, 李职, 等.泌乳母猪饲粮精氨酸水平对哺乳仔猪小肠黏膜发育的影响[J].动物营养学报, 2010, 22(4):870-878.

[40] 谭碧娥, 李新国, 孔祥峰, 等.精氨酸对早期断奶仔猪肠道生长、组织形态及IL-2基因表达水平的影响[J].中国农业科学, 2008, 41(9):2783-2788.

[41] TAN B, YIN Y L, ONG X F, et al.L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells[J].Amino Acids, 2010, 38(4):1227-1235.  

[42] 陈渝, 陈代文, 毛湘冰, 等.精氨酸对免疫应激仔猪肠道组织Toll样受体基因表达的影响[J].动物营养学报, 2011, 23(9):1527-1535.

[43] LIU Y L, HUANG J J, HOU Y Q, et al.Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs[J].British Journal of Nutrition, 2008, 100(3):552-560.  

[44] 赵宏丽, 孙海洲, 李金霞, 等.瘤胃保护性精氨酸及N-氨甲酰谷氨酸对细毛羊肠道黏膜蛋白质合成率的影响[J].动物营养学报, 2012, 24(11):2141-2147.

[45] 岳斌, 于艺辉.性控胶囊与精氨酸在奶牛性别控制中的应用试验[J].中国奶牛, 2012(1):21-22.

[46] 杨慧, 林登峰, 王恬, 等.饲粮中添加不同水平L-精氨酸对妊娠母猪繁殖性能及血液生化指标的影响[J].动物营养学报, 2012, 24(10):2013-2020.

[47] 杨慧, 林登峰, 林伯全, 等.饲粮中添加不同水平L-精氨酸对泌乳母猪生产性能、血清氨基酸浓度和免疫生化指标的影响[J].动物营养学报, 2012, 24(11):2103-2109.

[48] MATEO R D, WU G Y, BAZER F W, et al.Dietary L-arginine supplementation enhances the reproductive performance of gilts[J].The Journal of Nutrition, 2007, 137(3):652-656.

[49] ZENG X F, WANG F L, FAN X, et al.Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats[J].The Journal of Nutrition, 2008, 138(8):1421-1425.

[50] GREENE J M, DUNAWAY C W, BOWERS S D, et al.Dietary L-arginine supplementation during gestation in mice enhances reproductive performance and vegfr2 transcription activity in the fetoplacental unit[J].The Journal of Nutrition, 2012, 142(3):456-460.  

[51] LIU X D, WU X, YIN Y L, et al.Effects of dietary L-arginine or N-carbamylglutamate supplementation during late gestation of sows on the miR-15b/16, miR-221/222, VEGFA and eNOS expression in umbilical vein[J].Amino Acids, 2012, 42(6):2111-2119.  

[52] LUIKING Y C, ENGELEN M P, DEUTZ N E, et al.Regulation of nitric oxide production in health and disease[J].Current Opinion in Clinical Nutrition and Metabolic Care, 2010, 13(1):97-104.  

[53] KWAK H, AUSTIC R E, DIETERT R R.Influence of dietary arginine concentration on lymphoid organ growth in chickens[J].Poultry Science, 1999, 78(11):1536-1541.

[54] 闫伟, 施寿荣, 杨海明, 等.L-精氨酸对脂多糖刺激仔鹅生长发育的影响[J].动物营养学报, 2010, 22(4):1071-1075.

[55] 师昆景, 吴灵英, 谭荣炳.胚胎注射L-精氨酸和L-鸟氨酸对肉仔鸡早期生长、免疫器官及血浆激素T3、T4的影响[J].中国家禽, 2008, 30(17):25-28.

[56] HAN J, LIU Y L, FAN W, et al.Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs[J].Amino Acids, 2009, 37(4):643-651.  

[57] TAN B E, LI X G, KONG X F, et al.Dietary L-arginine supplementation enhances the immune status in early-weaned piglets[J].Amino Acids, 2009, 37(2):323-331.  

[58] 谭玲芳, 王安, 李越, 等.精氨酸对笼养生长期蛋鸭生长性能及免疫功能的影响[J].中国饲料, 2013(7):15-18.

[59] 柏美娟, 孔祥峰, 印遇龙, 等.日粮添加精氨酸对肥育猪免疫功能的调节作用[J].扬州大学学报:农业与生命科学版, 2009, 30(3):45-49.

[60] LI Q, LIU Y L, CHE Z Q, et al.Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs[J].Innate Immunity, 2012, 18(6):804-814.  
Outlines

/