Regulation of Epidermal Growth Factor on Intestinal Functions

LIU Shujie; XU Ziwei; QI Keke; WU Jie

doi:10.3969/j.issn.1006-267x.2014.03.002

Chinese Journal of Animal Nutrition >

2014 , Vol. 26 >Issue 3: 565 - 570

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.03.002

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Regulation of Epidermal Growth Factor on Intestinal Functions

LIU Shujie ,
XU Ziwei ,
QI Keke ,
WU Jie

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Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received date: 2013-10-08

Online published: 2014-03-04

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Abstract

Gastrointestinal health of animals determines their overall level of function and productivity, and the improvement of structure and function in intestine has a great influence on healthy growth of animals. However, some factors can cause intestinal injury, reduction of growth performance and immunity in animal production. Epidermal growth factor (EGF) is one of growth factor family members, which has many biological functions. EGF can stimulate cellular proliferation and differentiation, and enhance protein and DNA synthesis of epithelial tissues. The unique roles of EGF are promoting growth and development and repairing damage of the intestinal tract, which are related to intestinal structure and function. This paper reviewed the mediated signal pathways by EGF, and its biological functions such as promoting intestinal development, repairing damaged intestine, affecting enzyme activities in intestinal tract and improving digestion and absorption of nutrients.

Key words： epidermal growth factor; intestinal tract; signaling pathway; functional regulation

Cite this article

LIU Shujie , XU Ziwei , QI Keke , WU Jie . Regulation of Epidermal Growth Factor on Intestinal Functions[J]. Chinese Journal of Animal Nutrition, 2014 , 26(3) : 565 -570 . DOI: 10.3969/j.issn.1006-267x.2014.03.002

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