This study was conducted to compare the nutrient components of large yellow croaker (Pseudosciaena crocea Richardson) cultured in different modes fed different feeds and from different strains. Six wild Daiqu strain large yellow croaker captured in East China Sea (wild group), 6 Daiqu strain large yellow croaker cultured in pond which fed frozen fresh fish (pond group), 6 Daiqu strain large yellow croaker cultured in deep-water net cage which fed frozen fresh fish (deep-water net cage group), 6 Daiqu strain large yellow croaker cultured in net cage which fed frozen fresh fish (frozen fresh fish group), 6 Daiqu strain large yellow croaker cultured in net cage which fed artificial compound feed (feed group), and 6 Mindong satin large croaker yellow cultured in net cage which fed frozen fresh fish (Mindong group) were selected to analyze and compare the morphological indices (condition factor, viscerosomatic index and hepatosomatic index, n=6), common nutrient components (n=3) and amino acid composition in back muscle, abdominal muscle and whole body (n=3), fatty acid composition in back muscle (n=3), and heavy metal (inorganic arsenic, mercury, plumbum and chromium) contents in whole body (n=3). The results showed as follows: 1) the condition factor and hepatosmatic index of large yellow croaker in wild group were significantly lower than those in deep-water net cage group, pond group and frozen fresh fish group (P<0.05), while the condition factor and hepatosmatic index were not significantly different among groups cultured in different modes (P>0.05); the viscerosomatic index in feed group was significantly lower than that in frozen fresh fish group and Mindong group (P<0.05). 2) The crude lipid content in back muscle and abdominal muscle of large yellow croaker in wild group was the lowest, but no significant difference was found between wild group and feed group (P>0.05); the crude protein content in back muscle, abdominal muscle and whole body of large yellow croaker in wild group, frozen fresh fish group and feed group was higher than that in other groups, and no significant difference was found among above 3 groups (P>0.05);no significant difference was found in ash content in back muscle and abdominal muscle of large yellow croaker among all groups (P>0.05). 3) The contents of total amino acids, total essential amino acids, total flavor amino acids and total delicious amino acids in back muscle, abdominal muscle and whole body of large yellow croaker in wild group, frozen fresh fish group and feed group were higher than those in pond group, deep-water net cage group and Mindong group. 4) The contents of total fatty acids, total unsaturated fatty acids and highly unsaturated fatty acids in back muscle of large yellow croaker in wild group, feed group and deep-water net cage group were higher than those in frozen fresh fish group, pond group and Mindong group, and the lowest contents of total fatty acids and total unsaturated fatty acids in back muscle were found in Mindong group. 5) The large yellow croaker in wild group had a higher mercury content in whole body, and those in feed group had a higher chromium content in whole body, while the inorganic arsenic, mercury, plumbum and chromium contents in whole body of large yellow croaker in all groups were all in the safety range. These results indicate that different culture modes and different feed sources have significant effects on the nutrient components of large yellow croaker. Under the condition of cultured in the same mode and fed the same feed, the differences of nutrient components still exist among different strains of large yellow croaker.