Effects of Zinc Lactate on Intestinal Morphology, mRNA Expressions of Metallothioneins 1 in Intestinal Mucosa and Acute Phase Proteins in Tissues of Weaner Piglets

WANG Rongjiao; XIN Aiguo; ZHANG Chunyong; LI Meiquan; MEI Wennan; AN Qingcong; CHEN Kelin; GUO Rongfu

doi:10.3969/j.issn.1006-267x.2014.04.028

2014 , Vol. 26 >Issue 4: 1068 - 1076

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.04.028

Short Communications

Effects of Zinc Lactate on Intestinal Morphology, mRNA Expressions of Metallothioneins 1 in Intestinal Mucosa and Acute Phase Proteins in Tissues of Weaner Piglets

WANG Rongjiao ,
XIN Aiguo ,
ZHANG Chunyong ,
LI Meiquan ,
MEI Wennan ,
AN Qingcong ,
CHEN Kelin ,
GUO Rongfu

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1. Yunnan Animal Nutrition and Feed Laboratory, College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China;
2. Yunnan Animal Science and Veterinary Institute, Kunming 650224, China

Received date: 2013-10-21

Online published: 2014-04-01

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Abstract

This study was conducted to investigate the effects of zinc lactate on growth performance, intestinal morphology, metallothioneins 1(MT1) in intestinal mucosa and acute phase proteins (APP) mRNA expression in tissues. of‘duroc×landrace×york’ (DLY) weaner piglets Twenty-four (half male and half female) 35-day-old DLY weaner piglets in this study were randomly divided into control group and experimental group with 12 replicates per group and 1 piglet per replicate. Control group was fed a basal diet, while the experimental group was fed an experimental diet which was the basal diet added with zinc lactate (zinc added level at 100 mg/kg). The experiment lasted for 25 days. The results showed that, adding zinc lactate significantly improved the growth performance of weaner piglet (P<0.05), significantly increased villi length and decreased crypt depth of piglets (P<0.01), and significantly induced the upregulation of MT1 mRNA expression in duodenum, jejunum and ileum mucosa and APP mRNA expression in liver, pancreas, spleen, kidney, duodenum, jejunum and ileum of piglets (P<0.05). MT1 mRNA expression profile in small intestine was jejunum, duodenum and ileum, respectively; mRNA expressions of C-reactive protein (CRP), haptoglobin (HP), α1-acid glycoprotein (AGP) and serum amyloid-A (SAA) were detected the highest in the pancreas, kidney and liver, but trace expression in spleen and duodenum. It is suggested that zinc lactate significantly increase small intestinal villi length, decrease crypt depth, and zinc lactate may improve nutrient utilization, inducing the upregulation of CRP, HP, AGP and SAA mRNA expression in tissues by increasing MT1 mRNA expression in duodenum, jejunum and ileum, and increase disease resistance of piglets, thereby growth performance can be improved for weaner piglets.

Key words： weaner piglets; zinc lactate; intestinal morphology; MTs; APPs

Cite this article

WANG Rongjiao , XIN Aiguo , ZHANG Chunyong , LI Meiquan , MEI Wennan , AN Qingcong , CHEN Kelin , GUO Rongfu . Effects of Zinc Lactate on Intestinal Morphology, mRNA Expressions of Metallothioneins 1 in Intestinal Mucosa and Acute Phase Proteins in Tissues of Weaner Piglets[J]. Chinese Journal of Animal Nutrition, 2014 , 26(4) : 1068 -1076 . DOI: 10.3969/j.issn.1006-267x.2014.04.028

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