Nuclear Factor Erythroid-2-Related Factor 2 Mediated Antioxidant Pathway Character and Its Relation on Health and Meat Quality of Livestock and Poultry

LIN Qian; QIU Lei; YUN Long; CAO Rong; HE Xi; HOU Dexing

doi:10.3969/j.issn.1006-267x.2014.06.001

2014 , Vol. 26 >Issue 6: 1421 - 1429

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.06.001

Review

Nuclear Factor Erythroid-2-Related Factor 2 Mediated Antioxidant Pathway Character and Its Relation on Health and Meat Quality of Livestock and Poultry

LIN Qian ,
QIU Lei ,
YUN Long ,
CAO Rong ,
HE Xi ,
HOU Dexing

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1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. Department of Biochemical Science and Technology, Faculty of Agricultural, Kagoshima University, Kagoshima 890-0065, Japan

Received date: 2013-12-23

Online published: 2014-05-30

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Abstract

Nuclear factor erythroid-2-related factor 2 (Nrf2) is an important molecule in antioxidative and redox signaling. Nrf2 can be activated by conformational change of Keap1 or Nrf2 itself phosphorylation. The activated Nrf2 enters the nucleus and binds with antioxidant response element (ARE) to transactivate the expression of a series of antioxidant enzyme genes against the harmful stimuli. This review summarizes Nrf2-mediated antioxidant pathway and its regulatory role in anti-stress, meat quality, development of feed additives, and the impact in maintaining the health of livestock and poultry.

Key words： nuclear factor erythroid-2-related factor 2 (Nrf2); antioxidant response element (ARE); meat quality; antioxidation

Cite this article

LIN Qian , QIU Lei , YUN Long , CAO Rong , HE Xi , HOU Dexing . Nuclear Factor Erythroid-2-Related Factor 2 Mediated Antioxidant Pathway Character and Its Relation on Health and Meat Quality of Livestock and Poultry[J]. Chinese Journal of Animal Nutrition, 2014 , 26(6) : 1421 -1429 . DOI: 10.3969/j.issn.1006-267x.2014.06.001

References

[1] 蔡维霞,张军,胡大海.氧化和化学应激的防御性转导通路--Nrf2/ARE[J].中国生物化学与分子生物学报,2009,25(4):297-303.

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