[1] ITOH N, ORNITZ D M.Evolution of the
Fgf and
Fgfr gene families[J].Trends in Genetics, 2004, 20(11):563-569.
[2] 龚磊, 陈京, 白波.FGF21的生物学功能[J].生理科学进展, 2012, 43(5):390-392.
[3] GOETZ R, BEENKEN A, IBRAHIMI O A, et al.Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members[J].Molecular and Cellular Biology, 2007, 27(9):3417-3428.
[4] KHARITONENKOV A, SHIYANOVA T L, Koester A, et al.FGF-21 as a novel metabolic regulator[J].Journal of Clinical Investigation, 2005, 115(6):1627-1635.
[5] OGAWA Y, KUROSU H, YAMAMOTO M, et al.BetaKlotho is required for metabolic activity of fibroblast growth factor 21[J].Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(18):7432-7437.
[6] YIE J, HECHT R, PATEL J, et al.FGF21 N-and C-termini play different roles in receptor interaction and activation[J].FEBS Letters, 2009, 583(1):19-24.
[7] 尹彬彬, 王蕾, 宋莹, 等.FGF-21的研究进展[J].吉林医药学院学报, 2011, 32(4):226-229.
[8] WENTE W, EFANOV A M, BRENNER M, et al.Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways[J].Diabetes, 2006, 55(9):2470-2478.
[9] INAGAKI T, DUTCHAK P, ZHAO G, et al.Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21[J].Cell Metabolism, 2007, 5(6):415-425.
[10] NISHIMURA T, NAKATAKE Y, KONISHI M, et al.Identification of a novel FGF, FGF-21, preferentially expressed in the liver[J].Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 2000, 1492(1):203-206.
[11] KHARITONENKOV A, SHANAFELT A B.Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases[J].BioDrugs, 2008, 22(1):37-44.
[12] MICANOIC R, RACHES D W, DUNBAR J D, et al.Different roles of N-and C-termini in the functional activity of FGF21[J].Journal of Cellular Physiology, 2009, 219(2):227-234.
[13] WANG H, QIANG L, FARMER S R.Identification of a domain within peroxisome proliferator-activated receptor γ regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes[J].Molecular and Cellular Biology, 2008, 28(1):188-200.
[14] IZUMIYA Y, BINA H A, OUCHI N, et al.FGF21 is an Akt-regulated myokine[J].FEBS Letters, 2008, 582(27):3805-3810.
[15] FON TACER K, BOOKOUT A L, DING X, et al.Research resource:comprehensive expression atlas of the fibroblast growth factor system in adult mouse[J].Molecular Endocrinology, 2010, 24(10):2050-2064.
[16] 柳景华, 吕昀, 张立克, 等.成纤维细胞生长因子21基因在心脏中表达的研究[J].心肺血管病杂志2009, 28(6):415-418.
[17] BADMAN M K, PISSIOS P, KENNEDY A R, et al.Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states[J].Cell Metabolism, 2007, 5(6):426-437.
[18] 吕昀, 柳景华.成纤维细胞生长因子21:参与代谢调节的细胞因子[J].生理科学进展, 2011, 42(3):234-237.
[19] FISHER M, ESTALL J L, ADAMS A C, et al.Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21)
in vivo[J].Endocrinology, 2011, 152(8):2996-3004.
[20] 孙国鹏, 叶贤龙, 任桂萍, 等.成纤维细胞生长因子21对1型糖尿病动物模型的肝糖代谢影响及机制研究[J].生物化学与生物物理进展, 2011, 38(10):953-960.
[21] LI K, LI L, YANG M, et al.The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose-lipid metabolism
in vitro[J].Molecular and Cellular Endocrinology, 2012, 348(1):21-26.
[22] 李钶摇, 李伶摇, 杨刚毅.成纤维细胞生长因子21调控小鼠肝脏和脂肪细胞的糖脂代谢[J].中华内分泌代谢杂志, 2010, 26(8):699-702.
[23] 李伶, 杨刚毅.成纤维细胞生长因子-21对代谢的影响及可能的机制[J].中国糖尿病杂, 2011, 19(5):321-324.
[24] CAMPOREZ J P G, JORNAYVAZ F R, PETERSEN M C, et al.Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice[J].Endocrinology, 2013, 154(9):3099-3109.
[25] ZHU S L, REN G P, ZHANG Z Y, et al.Therapeutic effect of fibroblast growth factor 21 on hypertension induced by insulin resistance[J].Acta Pharmaceutica Sinica, 2013, 48(9):1409-1414.
[26] 李婷婷, 高丽昌, 唐禄, 等.成纤维细胞生长因子-21改善胰岛素抵抗肝细胞对葡萄糖的吸收及机制[J].中国药理学通报, 2012, 28(3):366-371.
[27] KIM H W, LEE J E, CHA J J, et al.Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in
db/db mice[J].Endocrinology, 2013, 154(9):3366-3376.
[28] LIN Z, TIAN H, LAM K S L, et al.Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice[J].Cell Metabolism, 2013, 17(5):779-789.
[29] MURATA Y, NISHIO K, MOCHIYAMA T, et al.Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet[J].PLos One, 2013, 8(7):e69330.
[30] 刘建雷, 李伶, 杨刚毅.成纤维细胞生长因子-21的研究进展[J].检验医学与临床, 2007, 4(7):642-643.
[31] 付晓霞, 王爱民.PPARγ及其配体与肝纤维化的研究进展[J].临床消化病杂志, 2010, 22(4):253-256.
[32] DUTCHAK P A, KATAFUCHI T, BOOKOUT A L, et al.Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones[J].Cell, 2012, 148(3):556-567.
[33] CUEVAS-RAMOS D, AGUILAR-SALINAS C A, GOMEZ-PEREZ F J.Metabolic actions of fibroblast growth factor 21[J].Current Opinion in Pediatrics, 2012, 24(4):523-529.
[34] CHEN W, HOO R L, KONISHI M, et al.Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes[J].Journal of Biological Chemistry, 2011, 286(40):34559-34566.
[35] ZHANG X, YEUNG D C Y, KARPISEK M, et al.Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans[J].Diabetes, 2008, 57(5):1246-1253.
[36] KHARITONENKOV A, LARSEN P.FGF21 reloaded:challenges of a rapidly growing field[J].Trends in Endocrinology & Metabolism, 2011, 22(3):81-86.
[37] ARCH J R S, TRAYHURN P.Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification[J].Frontiers in Physiology, 2013, 64(4):3389-3404.
[38] COSKUN T, BINA H A, SCHNEIDER M A, et al.Fibroblast growth factor 21 corrects obesity in mice[J].Endocrinology, 2008, 149(12):6018-6027.
[39] BADMAN M K, KOESTER A, FLIER J S, et al.Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis[J].Endocrinology, 2009, 150(11):4931-4940.
[40] LI H, FANG Q, GAO F, et al.Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride[J].Journal of Hepatology, 2010, 53(5):934-940.
[41] HOTTA Y, NAKAMURA H, KONISHI M, et al.Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver[J].Endocrinology, 2009, 150(10):4625-4633.
[42] KURO O M.Endocrine FGFs and Klothos:emerging concepts[J].Trends in Endocrinology & Metabolism, 2008, 19(7):239-245.
[43] EITMAN M L.GF21:a missing link in the biology of fasting[J].Cell Metabolism, 2007, 5(6):405-407.
[44] CHU A Y, WORKALEMAHU T, PAYNTER N P, et al.Novel locus including FGF21 is associated with dietary macronutrient intake[J].Human Molecular Genetics, 2013, 22(9):1895-1902.
[45] SARRUF D A, THALER J P, MORTON G J, et al.Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats[J].Diabetes, 2010, 59(7):1817-1824.
[46] VARADY J, RINGSEIS R, EDER K.Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs[J].Lipids Health and Disease, 2012(11):34-40.
