[1] SAULNIER D M, KOLIDA S, GIBSON G R.Microbiology of the human intestinal tract and approaches for its dietary modulation[J].Current Pharmaceutical Design, 2009, 15(13):1403-1414.
[2] EBERL G.A new vision of immunity:homeostasis of the super organism[J].Mucosal Immunology, 2010, 3(5):450-460.
[3] NEISH A S.Microbes in gastrointestinal health and disease[J].Gastroenterology, 2009, 136(1):65-80.
[4] HOOPER L V, LITTMAN D R, MACPHERSON A J.Interactions between the microbiota and the immune system[J].Science, 2012, 336(6068):1268-1273.
[5] LITTMAN D R, PAMER E G.Role of the commensal microbiota in normal and pathogenic host immune responses[J].Cell Host and Microbe, 2011, 10(4):311-323.
[6] MOAL V L, SERVIN A L.The front line of enteric host defense against unwelcome intrusion of harmful microorganisms:mucins, antimicrobial peptides, and microbiota[J].Clinical Microbiology Reviews, 2006, 19(2):315-337.
[7] DIDIERLAURENT A, SIRARD J C, KRAEHENBUHL J P, et al.How the gut senses its content[J].Cellular Microbiology, 2002, 4(2):61-72.
[8] RAKOFF-NAHOUM S, PAGLINO J, ESLAMI-VARZANEH F, et al.Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis[J].Cell, 2004, 118(2):229-241.
[9] CARIO E.Bacterial interactions with cells of the intestinal mucosa:toll-like receptors and NOD2[J].Gut, 2005, 54:1182-1193.
[10] LAVELLE E C, MURPHY C, O'NEILL L A J, et al.The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis[J].Mucosal Immunology, 2010, 3(1):17-28.
[11] SANTAOLALLA R, ABREU M T.Innate immunity in the small intestine[J].Current Opinion in Gastroenterology, 2012, 28(2):124-129.
[12] CARIO E.Barrier-protective function of intestinal epithelial Toll-like receptor 2[J].Mucosal Immunology, 2008, 1(Suppl.1):S62-S66.
[13] CARIO E.Toll-like receptors in inflammatory bowel diseases:a decade later[J].Inflammatory Bowel Diseases, 2010, 16(9):1583-1597.
[14] LALA S, OGURA Y, OSBORNE C, et al.Crohn's disease and the
NOD2 gene:a role for paneth cells[J].Gastroenterology, 2003, 125(1):47-57.
[15] JOHANSSON M E, LARSSON J M, HANSSON G C.The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions[J].Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(Suppl.1):S4659-S4665.
[16] JOHANSSON M E.Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by
in vivo labeling of mucin glycoproteins[J].PLoS One, 2012, 7(7):e41009.
[17] MEYER-HOFFERT U, HORNEF M W, HENRIQUES-NORMARK B, et al.Secreted enteric antimicrobial activity localises to the mucus surface layer[J].Gut, 2008, 57(6):764-771.
[18] MASUDA K, NAKAMURA K, YOSHIOKA S, et al.Regulation of microbiota by antimicrobial peptides in the gut[J].Advances in Oto-Rhino-Laryngology, 2011, 72:97-99.
[19] WEHKAMP J, STANGE E F.Paneth's disease[J].Journal of Crohn's and Colitis, 2010, 4(5):523-531.
[20] KLVVER E, ADERMANN K, SCHULZ A.Synthesis and structure-activity relationship of β-defensins, multi-functional peptides of the immune system[J].Journal of Peptide Science, 2006, 12(4):243-257.
[21] TAYLOR K, CLARKE D J, MCCULLOUGH B, et al.Analysis and separation of residues important for the chemoattractant and antimicrobial activities of β-defensin 3[J].The Journal of Biological Chemistry, 2008, 283(11):6631-6639.
[22] SCHROEDER B O, WU Z, NUDING S, et al.Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1[J].Nature, 2011, 469(7330):419-423.
[23] COBO R E, CHADEE K.Antimicrobial human β-defensins in the colon and their role in infectious and non-infectious diseases[J].Pathogens, 2013, 2(1):177-192.
[24] RUMIO C, BESUSSO D, PALAZZO M, et al.Degranulation of paneth cells via toll-like receptor 9[J].The American Journal of Pathology, 2004, 165(2):373-381.
[25] 薛现凤.猪β-防御素抗菌、抗氧化功能及其对肠上皮细胞黏膜屏障功能的影响[D].硕士学位论文.杭州:浙江大学, 2012.
[26] BAO H, SHE R, LIU T, et al.Effects of pig antibacterial peptides on growth performance and intestine mucosal immune of broiler chickens[J].Poultry Science, 2009, 88(2):291-297.
[27] LIU T, SHE R, WANG K, et al.Effects of rabbit sacculus rotundus antimicrobial peptides on the intestinal mucosal immunity in chickens[J].Poultry Science, 2008, 87(2):250-254.
[28] YANG Y R, JIANG Y B, SHE R P, et al.Effects of chicken intestinal antimicrobial peptides on humoral immunity of chickens and antibody titres after vaccination with infectious bursal disease virus vaccine in chicken[J].Archives of Animal Nutrition, 2006, 60(5):427-435.
[29] WU S D, ZHANG F R, HUANG Z M, et a1.Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli[J].Peptides, 2012, 35(2):225-230.
[30] HASHIMOTO T, PERLOT T, REHMAN A, et al.ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation[J].Nature, 2012, 487(7408):477-481.
[31] TELTSCHIK Z, WIEST R, BEISNER J, et al.Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense[J].Hepatology, 2012, 55(4):1154-1163.
[32] 王秀青, 张婵, 朱明星, 等.抗菌肽CecropinB对鸡肠道正常微生物群的影响[J].宁夏医科大学学报, 2010, 32(7):762-766.
[33] 余绍海.甘露寡糖、抗菌肽在肉用番鸭生产中的应用研究[D].硕士学位论文.扬州:扬州大学, 2006.
[34] 郭志强, 杨奉珠, 雷岷, 等.抗菌肽对肉兔小肠黏膜形态、盲肠菌群和免疫功能的影响[J].动物营养学报, 2012, 24(9):1778-1784.
[35] 杨奉珠.抗菌肽对新西兰兔生长性能、消化生理和免疫功能的影响研究[D].硕士学位论文.重庆:西南大学, 2012.
[36] YOONA J H, INGALEA S L, KIM J S, et a1.Effects of dietary supplementation of antimicrobial peptide-A3 on growth performance, nutrient digestibility, intestinal and fecal microflora and intestinal morphology in weanling pigs[J].Animal Feed Science and Technology, 2012, 177(1/2):98-107.
[37] PENG K S, SHE R P, YANG Y R, et a1.Anti-adherence of antibacterial peptides and oligosaccharides and promotion of growth and disease resistance in tilapia[J].Asian-Australasian Journal of Animal Sciences, 2007, 20(4):569-576.
[38] CARVALHO F A, AITKEN J D, VIJAY-KUMAR M, et a1.Toll-like receptor-gut microbiota interactions:perturb at your own risk[J].Annual Review of Physiology, 2012, 74:177-198.
[39] CHEEMA U B, YOUNAS M, SULTAN J I, et al.Antimicrobial peptides:an alternative of antibiotics in ruminants[J].Advances in Agricultural Biotechnology, 2011(2):15-21.
[40] 崔雅丽.动物抗菌肽饲料添加剂的应用与展望[J].畜禽业, 2010(4):12-14.
