Research Progress on the Regulation of Milk Protein Synthesis by Essential Amino Acids through Mammalian Target of Rapamycin Signaling Pathway

GAO Haina, ZHENG Nan, HU Han, WANG Jiaqi

doi:10.3969/j.issn.1006-267x.2014.09.002

2014 , Vol. 26 >Issue 9: 2451 - 2456

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.09.002

Review

Research Progress on the Regulation of Milk Protein Synthesis by Essential Amino Acids through Mammalian Target of Rapamycin Signaling Pathway

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1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
3. Ministry of Agriculture-Milk and Dairy Product Inspection Center, Beijing 100193, China;
4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2014-04-25

Online published: 2014-09-10

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Abstract

Recent studies showed that the essential amino acids not only functioned as the substrates of milk protein synthesis, but also as the signaling molecules to regulate milk protein synthesis. The regulation of milk casein by different essential amino acids through mammalian target of rapamycin (mTOR) signaling pathways is different, some amino acids have positive regulatory roles and others have negative ones. It is essential to further study on the molecular mechanism of milk protein synthesis regulation by different essential amino acids. In this review, the downstream of mTOR signaling pathways and milk protein synthesis regulation by essential amino acids through the mTOR signaling pathways were summarized.

Key words： essential amino acids; mTOR; casein

Cite this article

GAO Haina, ZHENG Nan, HU Han, WANG Jiaqi . Research Progress on the Regulation of Milk Protein Synthesis by Essential Amino Acids through Mammalian Target of Rapamycin Signaling Pathway[J]. Chinese Journal of Animal Nutrition, 2014 , 26(9) : 2451 -2456 . DOI: 10.3969/j.issn.1006-267x.2014.09.002

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