Review

Exogenous Polyamine: Effects on Intestinal Structure and Function in Piglet and Its Mechanism

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  • 1. Key Laboratory for Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China;
    2. College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330000, China

Received date: 2014-04-01

  Online published: 2014-09-10

Abstract

Polyamines(putrescine, spermidine, spermine) are growth factors in both prokaryote and eukaryote. Exogenous polyamine can promote the growth and development and the absorption of nutrients of the small intestine and is important to the growth, development and repair damage of the small intestinal mucosa. The appropriate amount of exogenous polyamines can alleviate intestinal structure and function damage caused by weaning, and help piglets to better adapt to the transition from breastfeeding to feed. The effects of polyamine on intestinal structure and function and its mechanisms were summarized in this article.

Cite this article

WANG Xiaocheng, XIONG Xia, GONG Min, YIN Yulong . Exogenous Polyamine: Effects on Intestinal Structure and Function in Piglet and Its Mechanism[J]. Chinese Journal of Animal Nutrition, 2014 , 26(9) : 2457 -2462 . DOI: 10.3969/j.issn.1006-267x.2014.09.003

References

[1] IGARASHI K,KASHIWAGI K.Bacterial and eukaryotic transport systems[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:433-448.

[2] SVENSSON F,PERSSON L.Regulation of ornithine decarboxylase and s-adenosylmethionine decarboxylase in a plyamine auxotrophic cell line[J].Molecular and Cellular Biochemistry,1996,162(2):113-121.

[3] VELLENGA L,WENSING T,EGBERTS H J A,et al.Intestinal permeability to macromolecules in piglets infected with transmissible gastroenteritis virus[J].Veterinary Research Communications,1988,12(6):481-489.  

[4] RUSSO F,LINSALATA M,GIORGIO I,et al.Polyamine levels and ODC activity in intestinal-type and diffuse-type gastric carcinoma[J].Digestive Diseases and Sciences,1997,42(3):576-579.  

[5] OSIPOVA L A,NEMLII N I,GRIDINA N I,et al.Effect of inhibitors of polyamine biosynthesis and od exogenous polyamines on mitogenic effect of epidermal growth factor in primary hepatocyte[J].Biull Eksp Biol Med,1989,107(3):339-342

[6] 张翥.腐胺对断奶仔猪的营养生理作用及对后续生长性能的影响[D].硕士学位论文.重庆:西南大学,2009:11-26.

[7] WU G Y,FLYNN E N,KNABEA D.Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets[J].American Journal of Physiology-Endocrinology and Metabolism,2000,279(2):E395-E402.

[8] LALLS J P,BOUDRY G,FAVIER C,et al.Gut function and dysfynction in young pigs:physiology[J].Animal Research,2004,53:301-316.

[9] KONG X F,YIN F G,HE Q H,et al.Acanthopanax senticosus extract as a dietary additive enhances the apparent ileal digestibility of amino acids in weaned piglets[J].Livestock Science,2009,123:261-267.

[10] PLUSKE R J,HAMPSONJ D,WILLIAMS H I,et al.Factors influencing the structure and function of the small intestine in the weaned pig:a review[J].Livestock Production Science,1997,51:215-236.

[11] CAMPBELL J M,CRENSHAW J D,POLO J.The biological stress of early weaned piglets[J].Journal of Animal Science and Biotechnology,2013,4(1):19-23.  

[12] 王红宁.仔猪腹泻成因及综合防治技术措施[J].中国畜牧杂志,2006,42(6):58-60.

[13] RAY R M,JOHNSON L R.Polyamines and cytoskeletal regulation during intestinal epithelial restitution[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:349-362.

[14] FLYNN N E,BIRD J G,GUTHRIE A S.Glucocorticoid regulation of amino acid and polyamine metabolism in the small intestine[J].Amino Acids,2009,37:123-129.

[15] OREDSSON S M.Polyamine-dependent early cellular signals and cell proliferation[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:41-50.

[16] RICHARD P,DENIS S,BRUNO G,et al.Evidence for a multistep model for eukaryotic polyamine transport[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:415-432.

[17] WOSTER P M.Polyamine structure and synthetic analogs[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:3-24.

[18] CASERO R A,Jr,FRASER A V,MURRAY-STEWART T,et al.Recent advances in the understanding of mammalian polyamine catabolism[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:205-231.

[19] GRANT A L,THOMAS J W, KING K J,et al.Effects of dietary amines on small intestinal variables in neonatal pigs fed soy protein isolate[J].Journal of Animal Science,1990,68:363-371.

[20] 程志斌,廖启顺,苏子峰.精胺促进仔猪肠道发育的作用与机理[J].饲料博览,2010(4):16-18.

[21] LÖSER C,EISEL A,HARMS D,et al.Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development[J].Gut,1999,44:12-16.

[22] JÄNNE J,ALHONEN L,PIETILÄ M,et al.Genntic engineering of polyamine catabolism in transgenic mice and rats[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:465-477.

[23] 邹伟,何余湧,陆伟.小肠粘膜二糖酶的发育规律及其影响因素[J].江西畜牧兽医杂志,2011(5):1-4.

[24] HAMPSON D J.Alterations in piglet small intestinal structure at weaning[J].Research in Veterinary Science,1986,40(1):32-40.

[25] MOLINA-SABATER M,LARQUE E,TORRELLA F,et al.Effects of dietary polyamines at physiologic doses in early-weaned piglets[J].Nutrition,2009,25(9):940-946.  

[26] 王猛,侯永清,丁斌鹰,等.精胺对断奶仔猪小肠组织形态的影响[J].动物营养学报,2007,19(4):366-371.

[27] 何余湧,邹伟,王仁华,等.饲料中添加精胺对哺乳仔猪血液生化指标及胃肠道发育的影响研究[J].饲料工业,2012,33(9):14-16.

[28] 廖启顺,苏子峰,程志斌,等.口服精胺对哺乳仔猪小肠生长的影响[J].饲料博览,2010(11):5-7.

[29] FUSI E,BALDI A,CHELI F,et al.Effects of putrescine,cadaverine,spermine,spermidine and β-phenylethylamine on cultured bovine mammary epithelial cells[J].Italian Journal of Animal Science,2008,7:131-140.

[30] 陶青燕,王康宁.哺乳期灌服亚精胺或精胺对早期断奶大鼠生长及肠道发育的影响[J].中国畜牧杂志,2009,45(9):24-27.

[31] RAO N J,WANG J Y.Regulation of Kv channel activity and intercellular junctions by polyamines in intestinal epithelial cells[M]//WANG J Y,CASERO R A,Jr.Polyamine Cell Signaling:Physiology,Pharmacology,and Cancer Research.Totowa:Humana Press Inc.,2006:363-381.

[32] GERNER E W.Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models[J].Biochemical Society Transactions,2007,35(Pt2):322-325.

[33] POWROZNIK B,GHARBI M,DANDRIFOSSE G,et al.Enhancement of lysozyme stability and activity by polyamines[J].Biochimie,2004,86:651-656.

[34] 何余湧,邹伟,刘晓兰,等.妊娠后期母猪和仔猪补饲外源精胺对初生和28日龄仔猪肠道形态结构及二糖酶活性的影响[J].动物营养学报,2012,24(8):1429-1437.

[35] 郭豫杰,张志强,王月影,等.仔猪多胺代谢相关基因的克隆及断奶对其mRNA表达的影响[J].农业生物技术学报,2012,20(8):893-900.

[36] 张翥,董国忠,张文火,等.断奶仔猪饲粮中添加腐胺的营养生理效应研究[J].中国畜牧杂志,2011,47(9):69-72.

[37] CHENG H,LEBLOND C P.Origin,differentiation and renewal of the four main epithelial cell types in the mouse small intestine I.Columnar cell[J].American Journal of Anatomy,1974,141(4):461-479.  

[38] WANG H,SCOTT R E.Induction of c-jun independent PKC,pertussis toxin-sensitive G protein,and polyamines in quiescent SV40-transformed 3T3 T cells[J].Experimental Cell Reserch.1992,203:47-55.

[39] 和俊涛,马建敏,宁黔冀,等.外源多胺对大鼠早期再生肝鸟氨酸脱羧酶蛋白水平的调节[J].解剖学报,2008,39(1):102-105.

[40] SOUSADIAS M G,SMITH T K.Toxicity and growth-promoting potential of spermine when fed to chicks[J].Journal of Animal Science,1995,73:2375-2381.
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