Effects of Intrauterine Growth Retardation on Growth Performance and Hepatic Oxidative and Antioxidative Parameters of Suckling Piglets

LI Bo, LI Wei, ZHANG Hao, ZHANG Lili, WANG Tian

doi:10.3969/j.issn.1006-267x.2014.09.046

2014 , Vol. 26 >Issue 9: 2822 - 2827

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.09.046

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Effects of Intrauterine Growth Retardation on Growth Performance and Hepatic Oxidative and Antioxidative Parameters of Suckling Piglets

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College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

Received date: 2014-03-24

Online published: 2014-09-10

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Abstract

The purpose of this study was to investigate the effects of intrauterine growth retardation (IUGR) on growth performance and hepatic oxidative and anti-oxidative parameters of suckling piglets. Ten pregnant sows with the similar parity and body condition were selected, and after parturition, ten normal body weight (NBW) piglets and ten IUGR piglets were selected according to birth weight. Thus, all piglets were distributed into 2 groups (NBW and IUGR groups, respectively). Determination of body weight was performed at specified days, and anti-oxidative parameters in the liver of pigs at 7 and 23 days of age were measured at slaughter. The results showed as follows: compared with NBW group, the body weight of pigs in IUGR group was significantly decreased at 7, 14, and 23 days of age, respectively (P<0.05), the average daily gain(ADG) of pigs in IUGR group was numerically decreased at 1 to 7 days of age (P=0.075), and there was a significant decrease in the ADG of pigs in IUGR group at 8 to 14 days of age and 15 to 23 days of age, respectively (P<0.05). IUGR significantly decreased the activity of catalase (CAT) in the liver of pigs compared with the NBW pigs at 7 days of age (P<0.05), and tendency toward decrease in total-oxidizing ability (T-AOC) (P=0.099) and the activity of superoxide dismutase (SOD) (P=0.076) were observed in IUGR group; at 23 days of age, a notably reduce was found in T-AOC and the activity of SOD in the liver of pigs in IUGR group (P<0.05), and there was a tendency to decrease the ability of 1,6-Bis(diphenylphosphino)hexane free radical (DPPH·) scavenging (P=0.098). In conclusion, IUGR has a permanent stunting effect on growth performance of pigs and damages hepatic antioxidant ability of pigs at 7 and 23 days of age.

Key words： intrauterine growth retardation; liver; growth performance; oxidation and anti-oxidation

Cite this article

LI Bo, LI Wei, ZHANG Hao, ZHANG Lili, WANG Tian . Effects of Intrauterine Growth Retardation on Growth Performance and Hepatic Oxidative and Antioxidative Parameters of Suckling Piglets[J]. Chinese Journal of Animal Nutrition, 2014 , 26(9) : 2822 -2827 . DOI: 10.3969/j.issn.1006-267x.2014.09.046

References

[1] PREDOJEVIC M,STANOJEVIC M,VASILJ O,et al.Prenatal and postnatal neurological evaluation of a fetus and newborn from pregnancy complicated with IUGR and fetal hypoxemia[J].Journal of Maternal-Fetal and Neonatal Medicine,2011,24(5):764-767.

[2] WU G,BAZER F W,DATTA S,et al.Proline metabolism in the conceptus:implications for fetal growth and development[J].Amino Acids,2008,35(4):691-702.

[3] BOBAK M.Outdoor air pollution,low birth weight,and prematurity[J].Environmental Health Perspectivest,2000,108(2):173-176.

[4] MATILAINEN R,HEINONEN K,SIREN-TIUSANEN H.Effect of intrauterine growth retardation (IUGR) on the psychological performance of preterm children at preschool age[J].Journal of Child Psychology and Psychiatry,1988,29(5):601-609.

[5] FERRO-LUZZI A,ASHWORTH A,MARTORELL R,et al.Report of the IDECG working group on effects of IUGR on infants,children and adolescents:immunocompetence,mortality,morbidity,body size,body composition,and physical performance[J].European Journal of Clinical Nutrition,1998,52(Suppl.1):S97-S99.

[6] 张贺,王承利,王洋,等.小型猪动物模型在医学领域中的研究应用[J].中国畜牧兽医,2012,39(7):263-266.

[7] XU R J,MELLOR D J,BIRTLES M J,et al.Impact of intrauterine growth retardation on the gastrointestinal tract and the pancreas in newborn pigs[J].Journal of Pediatric Gastroenterology & Nutrition,1994,18(2):231-240.

[8] HAN F,HU L,XUAN Y,et al.Effects of high nutrient intake on the growth performance,intestinal morphology and immune function of neonatal intra-uterine growth-retarded pigs[J].British Journal of Nutrition,2013,110(10):1819-1827.

[9] VAIMAN D,GASCOIN-LACHAMBRE G,BOUBRED F,et al.The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model[J].PLoS One,2011,6(6):e21222.

[10] WU G,BAZER F W,WALLACE J M,et al.Board-invited review:intrauterine growth retardation:implications for the animal sciences[J].Journal of Animal Science,2006,84:2316-2337.

[11] 张崇志,刘迎春,高峰,等.妊娠后期营养限饲对蒙古绵羊胎儿肝脏生长发育及抗氧化能力的影响[J].畜牧兽医学报,2013,44(8):1263-1268.

[12] ALEXANDRE-GOUABAU M C,COURANT F,LE GALL G,et al.Offspring metabolomic response to maternal protein restriction in a rat model of intrauterine growth restriction (IUGR)[J].Journal of Proteome Research,2011,10(7):3292-3302.

[13] 刘静波,姚英,余冰,等.叶酸对初产母猪繁殖性能和宫内发育迟缓仔猪肾脏功能基因表达的影响[J].动物营养学报,2010,22(2):278-284.

[14] SOYDINC H E,SAK M E,EVLIYAOGLU O,et al.Maternal plasma prolidase,matrix metalloproteinases 1 and 13,and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitis[J].Journal of the Turkish German Gynecological Association,2012,13(3):172-177.

[15] 陈伟,林映才,马现永,等.一些抗氧化剂的抗/促氧化作用及其机制[J].动物营养学报,2012,24(4):595-605.

[16] LIU J B,YAO Y,YU B,et al.Effect of folic acid supplementation on hepatic antioxidant function and mitochondrial-related gene expression in weanling intrauterine growth retarded piglets[J].Livestock Science,2012,146(2/3):123-132.

[17] KAMATH U,RAO G,KAMATH S U,et al.Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR)[J].Indian Journal of Clinical Biochemistry,2006,21(1):111-115.

[18] 王远孝,张莉莉,周根来,等.大豆卵磷脂对子宫内发育迟缓仔猪肠道抗氧化和热休克蛋白70表达的影响[J].中国农业科学,2012,45(13):2711-2717.

[19] KRESSIG P,BEINDER E,SCHWEER H,et al.Post-delivery oxidative stress in women with preeclampsia or IUGR[J].Journal of Perinatal Medicine,2008,36(4):310-315.

[20] BIRI A,BOZKURT N,TURP A,et al.Role of oxidative stress in intrauterine growth restriction[J].Gynecologic and Obsteteric Investigation,2007,64(4):187-192.

[21] YIN J,REN W,LIU G,et al.Birth oxidative stress and the development of an antioxidant system in newborn piglets[J].Free Radical Research,2013,47(12):1027-1035.

[22] NIERMEYER S,YANG P,ZHUANG J,et al.Arterial oxygen saturation in Tibetan and Han infants born in Lhasa,Tibet[J].The New England Journal of Medicine,1995,333(19):1248-1252.

[23] MYATT L,CUI X L.Oxidative stress in the placenta[J].Histochemistry and Cell Biology,122(4):369-382.

[24] PETERSIDE I E,SELAK M A,SIMMONS R A.Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats[J].American Journal of Physiology,Endocrinology and Metabolism,2003,285(6):E1258-E1266.

[25] SPARRE T,REUSENS B,CHERIF H,et al.Intrauterine programming of fetal islet gene expression in rats-effects of maternal protein restriction during gestation revealed by proteome analysis[J].Diabetologia,2003,46(11):1497-1511.

[26] LEE H C,WEI Y H.Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress[J].The International Journal of Biochemistry & Cell Biology,2005,37(4):822-834.

[27] PARK K S,KIM S K,KIM M S,et al.Fetal and early postnatal protein malnutrition cause long-term changes in rat liver and muscle mitochondria[J].The Journal of Nutrition,2003,133(10):3085-3090.

[28] 朱玉昌,焦必宁.ABTS法体外测定果蔬类总抗氧化能力的研究进展[J].食品与发酵工业,2005,31(8):77-80.

[29] 彭长连,陈少薇,林植芳,等.用清除有机自由基DPPH法评价植物抗氧化能力[J].生物化学与生物物理进展,2000,27(6):658-661.

[30] ZHANG J F,HOU X,AHMAD H,et al.Assessment of free radicals scavenging activity of seven natural pigments and protective effects in AAPH-challenged chicken erythrocytes[J].Food Chemistry,2014,145(15):57-65.

[31] DESSI A,ATZORI L,NOTO A,et al.Metabolomics in newborns with intrauterine growth retardation (IUGR):urine reveals markers of metabolic syndrome[J].Journal of Maternal-Fetal and Neonatal Medicine,2011,24 (Suppl.2):S35-S39.

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