Molecular Mechanism Underlying Meat Quality Formation and Its Nutritional Regulation in Pigs

YIN Jingdong, LI Defa

doi:10.3969/j.issn.1006-267x.2014.10.009

Chinese Journal of Animal Nutrition >

2014 , Vol. 26 >Issue 10: 2979 - 2985

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.10.009

Review

Molecular Mechanism Underlying Meat Quality Formation and Its Nutritional Regulation in Pigs

Expand

State Key Laboratory of Animal Nutrition, China University of Agriculture, Beijing 100193, China

Received date: 2014-07-31

Online published: 2015-01-23

Fold

Abstract

China has become the largest pork production country in the world for a few years in succession. However, Chinese pork international competitiveness hardly matches its status of pork production. Considering good pork quality embraces a great deal of market value and high quality pork is the ultimate aim for pig industry, it is essential that advancing technologies of improving the pork quality to guarantee the sustainable development of the pig industry in China. High quality pork should be produced by a healthy, safe and ecological pig industry. Originally, a study on pork quality focused on identification of the genetic and environmental causes which lead to low quality pork. Now, it has extended how to improve pork qualities, including fresh meat color, favor, tenderness, water hold capacity, and animal welfare. In this paper, we discussed advancing in molecular mechanism and nutrient metabolism underlying high quality pork formation through two major aspects of muscle biological characteristics, i.e. myofiber development and intramuscular fat deposition. Furthermore, we also reviewed the progress of nutritional regulation of pork quality, and proposed that genetic resources of Chinese indigenous pig breeds should be put more attention on based on predecessors’ achievements, and the approaches of nutrigenomics and integrative physiology should be applied to accelerate the setting up of strategies of high quality pork production in China.

Key words： pork; meat quality; myofiber type; intramuscular fat; nutritional regulation

Cite this article

YIN Jingdong, LI Defa . Molecular Mechanism Underlying Meat Quality Formation and Its Nutritional Regulation in Pigs[J]. Chinese Journal of Animal Nutrition, 2014 , 26(10) : 2979 -2985 . DOI: 10.3969/j.issn.1006-267x.2014.10.009

References

[1] KLONT R E,BROCKS L,EIKELNBOOM G.Muscle fibre type and meat quality[J].Meat Science,1998,49(1):S219-S229.

[2] KARLSSON A H,KLONT R E,FERNANDEZ X.Skeletal muscle fibres as factors for pork quality[J].Livestock Production Science,1999,60(2/3):255-269.

[3] CHANG K C,DA COSTA N,BLACKLEY R,et al.Relationships of myosin heavy chain fibre types to meat quality traits in traditional and modern pigs[J].Meat Science,2003,64(1):93-103.

[4] ARANY Z,LEBRASSEUR N,MORRIS C,et al.The transcriptional coactivator PGC-1β drives the formation of oxidative type IIX fibers in skeletal muscle[J].Cell Metabolism,2007,5(1):35-46.

[5] LIN J D,WU H,TARR P T,et al.Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres[J].Nature,2002,418(6899):797-801.

[6] RUSSELL A P,FEILCHENFELDT J,SCHREIBER S,et al.Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle[J].Diabetes,2003,52(12):2874-2881.

[7] SCHULER M,ALI F,CHAMBON C,et al.PGC1 alpha expression is controlled in skeletal muscles by PPARbeta,whose ablation results in fiber-type switching,obesity,and type 2 diabetes[J].Cell Metabolism,2006,4(5):407-414.

[8] TALMADGE R J,OTIS J S,RITTLER M R,et al.Calcineurin activation influences muscle phenotype in a muscle-specific fashion[J].BMC Cell Biology,2004,5:28.

[9] WANG Y X,ZHANG C L,YU R T,et al.Regulation of muscle fiber type and running endurance by PPARdelta[J].PLoS Biology,2004,2(10):e294.

[10] ZHAO W,SU Y H,SU R J,et al.The full length cloning of a novel porcine gene CFL2b and its influence on the MyHC expression[J].Molecular Biology Reports,2009,36(8):2191-2199.

[11] NIRO C,DEMIGNON J,VINCENT S,et al.Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome[J].Developmental Biology,2010,338(2):168-182.

[12] TSIKA R W,SCHRAMM C,SIMMER G,et al.Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype[J].The Journal of Biological Chemistry,2008,283:36154-36167.

[13] REHFELDT C,STICKLAND N C,FIEDLER I,et al.Environmental and genetic factors as sources of variation in skeletal muscle fibre number[J].Basic and Applied Myology,1999,9(5):235-253.

[14] LEFAUCHEUR L,ECOLAN P,BARZIC Y M,et al.Early postnatal food intake alters myofiber maturation in pig skeletal muscle[J].The Journal of Nutrition,2003,133(1):140-147.

[15] HARRISON A P,ROWLERSON A M,DAUNCEY M J.Selective regulation of myofiber differentiation by energy status during postnatal development[J].The American Journal of Physiology,1996,270:R667-R674.

[16] WHITE P,CATTANEO D,DAUNCEY M J.Postnatal regulation of myosin heavy chain isoform expression and metabolic enzyme activity by nutrition[J].The British Journal of Nutrition,2000,84(2):185-194.

[17] VETTOR R,MILAN G,FRANZIN C,et al.The Origin of intermuscularadipose tissue and its pathophysiological implications[J].American Journal of Physiology: Endocrinology and Metabolism,2009,297(5):E987-E998.

[18] TISCHENDORF F,SCHONE F,KIRCHHEIM U,et al.Influence of a conjugated linoleic acid mixture on growth,organ weights,carcass traits and meat quality in growing pigs[J].Journal of Animal Physiology and Animal Nutrition,2002,86(3/4):117-128.

[19] ZHOU X,LI D F,YIN J D,et al.CLA differently regulates adipogenesis in stromal vascular cells from porcine subcutaneous adipose and skeletal muscle[J].The Journal of Lipid Resarch,2007,48:1701-1709.

[20] LIN J,ARNOLD H B,DELLA-FERA M A,et al.Myostatin knockout in mice increases myogenesis and decreases adipogenesis[J].Biochemical and Biophysical Research Communications,2002,291(3):701-706.

[21] HOBERT O.MiRNAs play a tune[J].Cell,2007,131(1):22-24.

[22] BOSTJANCIC E,ZIDAR N,STAJER D,et al.MicroRNAs miR-1,miR-133a,miR-133b and miR-208 are dysregulated in human myocardial infarction[J].Cardiology,2010,115(3):163-169.

[23] KIM H K,LEE Y S,SIVAPRASAD U,et al.Muscle-specific microRNA miR-206 promotes muscle differentiation[J].The Journal of Cell Biology,2006,174(5):677-687.

[24] XU C Q,LU Y J,PAN Z W,et al.The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60,HSP70 and caspase-9 in cardiomyocytes[J].Journal of Cell Science,2007,120:3045-3052.

[25] STOCKER C J,ARCH J R S,CAWTHORNE M A.Fetal origins of insulin resistance and obesity[J].Proceedings of the Nutrition Society,2005,64(2):143-151.

[26] LANGLEY-EVANS S C.Developmental programming of health and disease[J].Proceedings of the Nutrition Society,2006,65(1):97-105.

[27] KAPOOR A,DUNN E,KOSTAKI A,et al.Fetal programming of hypothalamo-pituitary-adrenal function:prenatal stress and glucocorticoids[J].The Journal of Physiology,2006,572:31-44.

[28] BELLINGER L,LANGLEY-EVANS S C.Fetal programming of appetite by exposure to a maternal low-protein diet in the rat[J].Clinical Science (London),2005,109:413-420.

[29] LANGLEY-EVANS S C,BELLINGER L,MCMULLEN S.Animal models of programming:early life influences on appetite and feeding behaviour[J].Maternal & Child Nutrition,2005,1(3):142-148.

[30] GARDNER D S,TINGEY K,VAN BON B W M,et al.Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2005,289(4):R947-R954.

[31] SZYF M,WEAVER I C,CHAMPAGNE F A,et al.Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat[J].Frontiers in Neuroendocrinology,2005,26(3/4):139-162.

[32] REES W D,HAY S M,CRUICKSHANK M,et al.Maternal protein intake in the pregnant rat programs the insulin axis and body composition in the offspring[J].Metabolism,2006,55(5):642-649.

[33] DRAKE A J,WALKER B R,SECKL J R.Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2005,288(1):R34-R38.

[34] MOSTYN A,SEBERT S,LITTEN J C,et al.Influence of porcine genotype on the abundance of thyroid hormones and leptin in sow milk and its impact on growth,metabolism and expression of key adipose tissue genes in offspring[J].Journal of Endocrinology,2006,190:631-639.

[35] SRINIVASAN M,AALINKEEL R,SONG F,et al.Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia,and adult-onset obesity and maternal mild food restriction reverses this phenotype[J].American Journal of Physiology: Endocrinology and Metabolism,2006,290(1):E129-E134.

[36] MILAN D,JEON J T,LOOFT C,et al.A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle[J].Science,2000,288(5469):1248-1251.

[37] BARNES B R,MARKLUND S,STEILER T L,et al.The 5'-AMP-activated protein kinase γ3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle[J].The Journal of Biological Chemistry,2004,279:38441-38447.

[38] CERISUELO A,BAUCELLS M D,GASA J,et al.Increased sow nutrition during midgestation affects muscle fiber development and meat quality,with no consequences on growth performance[J].Journal of Animal Science,2009,87(2):729-739.

[39] ROSENVOLD K,PETERSEN J S,LWERKE H N,et al.Muscle glycogen stores and meat quality as affected by strategic finishing feeding of slaughter pigs[J].Journal of Animal Science,2001,79(2):382-391.

[40] ROSENVOLD K,ANDERSSN H J.Factors of significance for pork quality—a review[J].Meat Science,2003,64(3):219-237.

[41] BEE G,BIOLLEY C,GUEX G,et al.Effects of available dietary carbohydrate and preslaughter treatment on glycolytic potential,protein degradation,and quality traits of pig muscles[J].Journal of Animal Science,2006,84(1):191-203.

[42] TAN B,YIN Y L,LIU Z Q,et al.Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs[J].Amino Acids,2009,37(1):169-175.

[43] LIU Y,LV W,YU B,et al.S-adenosylmethionine-induced adipogenesis is accompanied by suppression of Wnt/β-catenin and Hedgehog signaling pathways[J].Molecular and Cellular Biochemistry,2013,382(1/2):59-73.

[44] MADDOCK R J,BIDNER B S,CARR S N,et al.Creatine monohydrate supplementation and the quality of fresh pork in normal and halothane carrier pigs[J].Journal of Animal Science,2002,80(4):997-1004.

[45] LU P,LI D F,YIN J D,et al.Flavour differences of cooked longissimus muscle from Chinese indigenous pig breeds and hybrid pig breed(Duroc× Landrace× Large White)[J].Food Chemistry,2008,107 (4):1529-1537.

[46] HUANG Z Q,CHEN D W,ZHANG K Y,et al.Regulation of myostatin signaling by c-Jun N-terminal kinase in C2C12 cells[J].Cellular Signalling,2007,19(11):2286-2295.

[47] SHAN T Z,REN Y,WU T,et al.Regulatoryrole of sirt1 on the gene expression of fatty acid-binding protein 3 in cultured porcine adipocytes[J].Journal of Cellular Biochemistry,2009,107(5):984-991.

[48] CHEN J,YANG X J,XIA D,et al.Expression and polymorphism of SREBP-1 in the longissimus muscle associated with intramuscular fat deposition in Erhualian and Sutai pigs[J].Journal of Animal Science,2008,86(1):57-63.

[49] LI X,YANG X,SHAN B,et al.Meat quality is associated with muscle metabolic status but not contractile myofiber type composition in premature pigs[J].Meat Science,2009,81(1):218-223.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References