Review

Immunoregulatory Effect and Mechanism of Tryptophan on Maternal-Fetal Interface of Mammals

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  • 1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;
    2. College of Food Science and Engineering, Nanchang University, Nanchang 330031, China;
    3. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    4. Department of Animal Science, Texas A&M University, College Station 77843, USA

Received date: 2014-08-13

  Online published: 2015-01-23

Abstract

Recently, researchers found that amino acids could improve the reproductive capacity of sows. A few in vivo and in vitro studies showed that tryptophan and its metabolites could improve the reproductive capacity and reduce the abortion rate of sows. This paper reviewed the effect of tryptophan and its metabolites via kynurenine pathway on the immunoloregulation (or immunologic tolerance) of maternal-fetal interface of mammals (mainly pigs and rats), and the regulatory effect of tryptophan and its metabolites (such as kynurenine and 3-hydroxykynurenine) on decidual natural killer (dNK) cell, regulatory T cell (Treg) and type 17 helper T cell (Th17) in maternal-fetal interface of mammals and their possible mechanisms.

Cite this article

RUAN Zheng, YIN Yulong, WU Guoyao . Immunoregulatory Effect and Mechanism of Tryptophan on Maternal-Fetal Interface of Mammals[J]. Chinese Journal of Animal Nutrition, 2014 , 26(10) : 2986 -2991 . DOI: 10.3969/j.issn.1006-267x.2014.10.010

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