[1] BISCHOFF S C.'Gut health’:a new objective in medicine[J].BMC Medicine,2011,9:24.
[2] LAMBERT G P.Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects[J].Journal of Animal Science,2009,87(14S):E101-E108.
[3] BAUMGART D C,DIGNASS A U.Intestinal barrier function[J].Current Opinion in Clinical Nutrition and Metabolic Care,2002,5(6):685-694.
[4] KELLY G S.Clinical applications of N-acetylcysteine[J].Alternative Medicine Review:A Journal of Clinical Therapeutic,1998,3(2):114-127.
[5] 张再重,王瑜,王烈,等.N-乙酰半胱氨酸对肠屏障功能障碍防治作用的研究现状[J].临床军医杂志,2007,35(5):756-759.
[6] WANG Q J,HOU Y Q,YI D,et al.Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model[J].BMC Gastroenterology,2013,13(1):133.
[7] HOU Y Q,WANG L,YI D,et al.N-acetylcysteine reduces inflammation in the small intestine by regulating redox,EGF and TLR4 signaling[J].Amino Acids,2013,45(3):513-522.
[8] HOU Y Q,WANG L,ZHANG W,et al.Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide[J].Amino Acids,2012,43(3):1233-1242.
[9] 胡尧,张丽丽,侯永清,等.N-乙酰半胱氨酸对脂多糖应激仔猪生长性能及血浆生化指标的影响[J].动物营养学报,2010,22(4):1007-1011.
[10] 王蕾,侯永清.α-酮戊二酸对动物肠道黏膜作用的研究进展[C]//饲料营养研究进展.北京:中国农业科学技术出版社,2010:222-229.
[11] 胡泉舟,侯永清,丁斌鹰,等.α-酮戊二酸对仔猪小肠组织学形态与功能的影响[J].动物营养学报,2008,20(6):662-667.
[12] 张伟.N-乙酰半胱氨酸对脂多糖刺激仔猪肠道屏障功能及抗氧化能力的影响[D].硕士学位论文.武汉:武汉工业学院,2011.
[13] WU G Y,MEININGER C J,KNABE D A,et al.Arginine nutrition in development,health and disease[J].Current Opinion in Clinical Nutrition and Metabolic Care,2000,3(1):59-66.
[14] TAKATSUKA S,MORITA T,HORIKIRI Y,et al.Absorption enhancement of poorly absorbed hydrophilic compounds from various mucosal sites by combination of mucolytic agent and nonionic surfactant[J].International Journal of Pharmaceutics,2007,338(1/2):87-93.
[15] HOU Y Q,WANG L,DING B Y,et al.Alpha-ketoglutarate and intestinal function[J].Frontiers in Bioscience,2011,16:1186-1196.
[16] LUK G D,BAYLESS T M,BAYLIN S B,et al.Plasm a postheparin diamine oxidase.Sensitive provocative test for quantitating length of acute intestinal mucosa injury in the rat[J].The Journal of Clinical Investigation,1983,71(5):1308-1315.
[17] 黎君友,吕艺,付小兵,等.二胺氧化酶在创伤后肠道损伤中变化及意义[J].中国危重病急救医学,2000,12(8):482-484.
[18] 孙莹杰,曹惠鹃,张铁铮,等.N-乙酰半胱氨酸对体外循环期间大鼠肠屏障功能的影响[J].天津医药,2009,37(2):128-130.
[19] OCAL K,AVLAN D,CINEL I,et al.The effect of N-acetylcysteine on oxidative stress in intestine and bacterial translocation after thermal injury[J].Burns,2004,30 (8):778-784.
[20] NISHI K,ODA T,TAKABUCHI S,et al.LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner[J].Antioxidants & Redox Signaling,2008,10(5):983-996.
[21] 王咏梅.自由基与谷胱甘肽过氧化物酶[J].解放军药学学报,2005,21(5):369-371.
[22] 宋玉果,王涤新.谷胱甘肽作为脂质过氧化损伤指标的研究[J].中华预防医学杂志,1999,33(5):317-319.
[23] 刘平祥.谷胱甘肽对断奶仔猪的促生长作用及其机制[D].博士学位论文.广州:华南农业大学,2002.
[24] 乔小蓉,张静,郑海霞,等.血清氧化-还原态的监测及其与细胞损伤的关系[J].四川生理科学杂志,2004,26(1):16-21.
[25] FUKATA M,VAMADEVAN A S,ABREU M T.Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders[J].Seminars in Immunology,2009,21(4):242-253.
[26] 杨震国.N-乙酰半胱氨酸对脂多糖刺激仔猪免疫应激及能量状况的影响[D].硕士学位论文.武汉:武汉工业学院,2011.
[27] RAHMAN I.Regulation of nuclear factor-κB,activator protein-1,and glutathione levels by tumor necrosis factor-α and dexamethasone in alveolar epithelial cells[J].Biochemical Pharmacology,2000,60(8):1041-1049.
[28] 刘坚,侯永清,丁斌鹰,等.α-酮戊二酸对脂多糖应激仔猪肠黏膜能量代谢的影响[J].动物营养学报,2009,21(6):892-896.
[29] HARDIE D G,SCOTT J W,PAN D A,et al.Management of cellular energy by the AMP-activated protein kinase system[J].FEBS Letters,2003,546(1):113-120.
[30] 陈代文,张克英.AMPK对动物营养代谢的调节作用[J].动物营养学报,2002,14(3):1-6.
[31] HOU Y Q,YAO K,WANG L,et al.Effects of α-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide[J].The British Journal of Nutrition,2011,106(3):357-363.
[32] ZAFARULLAH M,LI W Q,SYLVESTER J,et al.Molecular mechanisms of N-acetylcysteine actions[J].Cellular and Molecular Life Sciences,2003,60(1):6-20.
[33] FASINA Y O,MORAN E T,ASHWELL C M,et al.Effect of dietary gelatin supplementation on the expression of selected enterocyte genes,intestinal development and early chick performance[J].International Journal of Poultry Science,2007,6 (12):944-951.
[34] ENGLER J A,GUPTA A,LI L,et al.Inhibition of DNA synthesis in Caco-2 cells by oxidative stress amelioration by epidermal growth factor[J].Digestive Diseases and Sciences,1999,44(9):1902-1909.
[35] RYAN C K,MILLER J H,SEYDEL A S,et al.Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy[J].Journal of Gastrointestinal Surgery,1997,1(5):467-473.
[36] HELMRATH M A,SHIN C E,ERWIN C R.Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression[J].Journal of Pediatric Surgery,1998,33(7):980-985.
[37] NAIR R R,WARNER B B,WARNER B W.Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis[J].Seminars in Perinatology,2008,32(2):107-113.
[38] FURUSE M,FUJITA K,HIIRAGI T,et al.Claudin-1 and -2:novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludeing[J].Journal of Cell Biology,1998,141 (7):1539-1550.
