Review

Effects of Early Weaning Stress on Intestinal Barrier Function in Piglets and Its Monitoring and Repair

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  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Institute of Animal and Veterinary Science, Changsha 410131, China

Received date: 2014-05-05

  Online published: 2014-11-17

Abstract

In pig production, daily gain commonly used to measure the health and growth performance of weaned piglets. At weaning, the piglets is subjected to myriad of stressors (the diet change, separation from mother and littermates, new environment and so on) which cause reduced daily gain. Associated with weaning are marked changes the histology and physiology of the intestinal, such as villous atrophy, crypt hyperplasia and increased permeability of the intestinal mucosa, which cause decreased digestive and absorptive capacity, immune functional decline, contribute to post-weaning diarrhoea and poor growth performance of the weaned pigs. The focus of this review paper was to describe how the early weaning stress impact intestinal mucosa structure and barrier functions in briefly, summarized some markers that could be used as evaluation of intestinal mucosa structure and barrier functions, and listed some feed ingredients or additives which could be used to relieve the damage of weaning stress, in order to provide some help to the production of piglets and study on early weaning stress.

Cite this article

WANG Xiangrong, HE Jianhua, DAI Qiuzhong, FANG Rejun . Effects of Early Weaning Stress on Intestinal Barrier Function in Piglets and Its Monitoring and Repair[J]. Chinese Journal of Animal Nutrition, 2014 , 26(11) : 3197 -3202 . DOI: 10.3969/j.issn.1006-267x.2014.11.002

References

[1] JENSEN P,RECÉN B.When to wean-observations from free-ranging domestic pigs[J].Applied Animal Behaviour Science,1989,23(1/2):49-60.

[2] VAN DER MEULEN J,KOOPMANS S J,DEKKER R A,et al.Increasing weaning age of piglets from 4 to 7 weeks reduces stress,increases post-weaning feed intake but does not improve intestinal functionality[J].Animal:an International Journal of Animal Bioscience,2010,4(10):1653-1661.  

[3] COLSON V,ORGEUR P,FOURY A,et al.Consequences of weaning piglets at 21 and 28 days on growth,behaviour and hormonal responses[J].Applied Animal Behaviour Science,2006,98(1/2):70-88.

[4] VAN BEERS-SCHREURS H M G,BRUININX E M A M.Nutritional management to prevent disorders in post-weaning pig health[M]//Nutrition and health of the gastrointestinal tract.Wageningen:Wageningen Academic Publishers,2002:135-158.

[5] 杨家军,张敏红,冯京海.早期断奶对仔猪肠上皮细胞氧化与损伤的影响[J].安徽农业大学学报,2013,40(1):77-82.

[6] YIN J,WU M M,XIAO H,et al.Development of an antioxidant system after early weaning in piglets[J].Journal of Animal Science,2014,92(2):612-619.  

[7] CAMPBELL J M,CRENSHAW J D,POLO J.The biological stress of early weaned piglets[J].Journal of Animal Science and Biotechnology,2013,4(1):19-22.  

[8] LE DIVIDICH J,SÈVE B.Effects of underfeeding during the weaning period on growth,metabolism,and hormonal adjustments in the piglet[J].Domestic Animal Endocrinology,2000,19(2):63-74.  

[9] TOKACH M D,GOODBAND R D,NELSSEN J L,et al.Influence of weaning weight and growth during the first week postweaning on subsequent pig performance[C]//Kansas State University Swine Day 1992.Manhattan:Kansas State University,1992:19-21.

[10] TZIPORI S,CHANDLER D,SMITH M,et al.Factors contributing to postweaning diarrhoea in a large intensive piggery[J].Australian Veterinary Journal,1980,56(6):274-278.  

[11] FAIRBROTHER J M,NADEAU E,GYLES C L.Escherichia coli in postweaning diarrhea in pigs:an update on bacterial types,pathogenesis,and prevention strategies[J].Animal Health Research Reviews,2007,6(1):17-39.

[12] LECCE J G,BALSBAUGH R K,CLARE D A,et al.Rotavirus and hemolytic enteropathogenic Escherichia coli in weanling diarrhea of pigs[J].Journal of Clinical Microbiology,1982,16(4):715-723.

[13] HAMPSON D J,HINTON M,KIDDER D E.Coliform numbers in the stomach and small intestine of healthy pigs following weaning at three weeks of age[J].Journal of Comparative Pathology,1985,95(3):353-362.  

[14] MILLER B,NEWBY T,STOKES C,et al.Influence of diet on postweaning malabsorption and diarrhoea in the pig[J].Research in Veterinary Science,1984,36(2):187-193.

[15] 陈代文,杨凤,陈可容.补料及开食料中不同种类蛋白质对仔猪过敏反应及腹泻程度的影响[J].畜牧兽医学报,1995,26(3):200-206.

[16] 伍晓雄.断奶应激导致仔猪腹泻的内分泌机理研究[J].动物医学进展,1999,20(2):7-8.

[17] 王莉,汪蕊,王希彪.仔猪HSP70蛋白表达与断奶腹泻关系研究[J].东北农业大学学报,2011,42(12):29-32.

[18] MCLAMB B L,GIBSON A J,OVERMAN E L,et al.Early weaning stress in pigs impairs innate mucosal immune responses to enterotoxigenic E.coli challenge and exacerbates intestinal injury and clinical disease[J].PLoS One,2013,8(4):e59838.

[19] PLUSKE J R,HAMPSON D J,WILLIAMS I H.Factors influencing the structure and function of the small intestine in the weaned pig:a review[J].Livestock Production Science,1997,51(1):215-236.

[20] BOUDRY G,PRON V,LE HUROU-LURON I,et al.Weaning induces both transient and long-lasting modifications of absorptive,secretory,and barrier properties of piglet intestine[J].The Journal of Nutrition,2004,134(9):2256-2262.

[21] MOESER A J,KLOK C V,RYAN K A,et al.Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2007,292(1):G173-G181.

[22] MCCRACKEN B A,SPURLOCK M E,ROOS M A,et al.Weaning anorexia may contribute to local inflammation in the piglet small intestine[J].The Journal of Nutrition,1999,129(3):613-619.

[23] HAMPSON D.Alterations in piglet small intestinal structure at weaning[J].Research in Veterinary Science,1986,40(1):32-40.

[24] 栾兆双,姚丽丽,傅振宁,等.断奶应激对仔猪肠形态、肠黏膜屏障和p38丝裂原活化蛋白激酶信号通路的影响[J].动物营养学报,2012,24(11):2237-2242.

[25] ITOH H,YAGI M,HASEBE K,et al.Regeneration of small intestinal mucosa after acute ischemia-reperfusion injury[J].Digestive Diseases and Sciences,2002,47(12):2704-2710.  

[26] PRASAD M,ITO S,SILEN W.Functional studies of in vitro rat distal colon before and after restitution[J].Surgery,1997,121(4):430-439.  

[27] SMITH F,CLARK J E,OVERMAN B L,et al.Early weaning stress impairs development of mucosal barrier function in the porcine intestine[J].American Journal of physiology Gastrointestinal and Liver Physiology,2010,298(3):G352-G363.

[28] 钱仲仓,刘海萍,徐勇,等.早期断奶应激对仔猪血清皮质醇含量和肠形态及肠屏障通透性的影响[J].西北农林科技大学学报:自然科学版,2009,37(10):62-66.

[29] MONTAGNE L,BOUDRY G,FAVIER C,et al.Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning[J].British Journal of Nutrition,2007,97(1):45-57.  

[30] NABUURS M J A,HOOGENDOORN A,VAN DER MOLEN E J,et al.Villus height and crypt depth in weaned and unweaned pigs,reared under various circumstances in the Netherlands[J].Research in Veterinary Science,1993,55(1):78-84.  

[31] 钟武装,宋卫兵,杨键,等.炎症性肠病患者黏附分子-l、D-乳酸、二胺氧化酶的变化及临床意义[J].现代消化及介入诊疗,2013,18(5):273-276.

[32] WIJTTEN P J A,VERSTIJNEN J J,VAN KEMPEN T A T G,et al.Lactulose as a marker of intestinal barrier function in pigs after weaning[J].Journal of Animal Science,2011,89(5):1347-1357.  

[33] 王秋菊,崔一喆,孙鹏,等.早期断奶对仔猪小肠碱性磷酸酯酶活力的影响[J].动物营养学报,2013,25(5):959-967.

[34] 孙志洪,贺志雄,张庆丽,等.尤斯灌流系统在动物胃肠道屏障及营养物质转运中的应用[J].动物营养学报,2010,22(3):511-518.

[35] 刘海萍,胡彩虹,徐勇.早期断奶对仔猪肠通透性和肠上皮紧密连接蛋白Occludin mRNA表达的影响[J].动物营养学报,2008,20(4):442-446.

[36] TAO X,XU Z W.MicroRNA transcriptome in swine small intestine during weaning stress[J].PLoS One,2013,8(11):e79343.

[37] SPREEUWENBERG M A M,VERDONK J M A J,GASKINS H R,et al.Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning[J].The Journal of Nutrition,2001,131(5):1520-1527.

[38] 谢天宇,胡红莲,高民.肠黏膜免疫屏障及其保护措施[J].动物营养学报,2014,26(5):1157-1163.

[39] MORETÓ M,PÉREZ-BOSQUE A.Dietary plasma proteins,the intestinal immune system,and the barrier functions of the intestinal mucosa[J].Journal of Animal Science,2009,87(14 Suppl):E92-E100.

[40] PEACE R M,CAMPBELL J,POLO J,et al.Spray-dried porcine plasma influences intestinal barrier function,inflammation,and diarrhea in weaned pigs[J].The Journal of Nutrition,2011,141(7):1312-1317.  

[41] REN M,LIU C,ZENG X,et al.Amino acids modulates the intestinal proteome associated with immune and stress response in weaning pig[J].Molecular Biology Reports,2014,41(6):3611-3620.  

[42] HE Q H,TANG H R,REN P P,et al.Dietary supplementation with l-arginine partially counteracts serum metabonome induced by weaning stress in piglets[J].Journal of Proteome Research,2011,10(11):5214-5221.  

[43] ZHENG P,YU B,HE J,et al.Protective effects of dietary arginine supplementation against oxidative stress in weaned piglets[J].British Journal of Nutrition,2013,109(12):2253-2260.  

[44] ZHU L H,CAI X,GUO Q,et al.Effect of N-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets[J].British Journal of Nutrition,2013,110(11):1938-1947.  

[45] 胡彩虹,钱仲仓,刘海萍,等.高锌对早期断奶仔猪肠黏膜屏障和肠上皮细胞紧密连接蛋白表达的影响[J].畜牧兽医学报,2009,40(11):1638-1644.

[46] HU C H,SONG J,YOU Z T,et al.Zinc oxide-montmorillonite hybrid influences diarrhea,intestinal mucosal integrity,and digestive enzyme activity in weaned pigs[J].Biological Trace Element Research,2012,149(2):190-196.  

[47] 刘虎传,张敏红,李素霞,等.益生菌制剂对早期断奶仔猪肠道pH、黏膜形态结构和挥发性脂肪酸含量的影响[J].动物营养学报,2012,24(7):1329-1335.

[48] 唐志如,邓欢,孙卫忠等.口服益生菌Escherichia coli Nissle 1917调控断奶仔猪空肠黏膜屏障功能的机理研究[J].畜牧兽医学报,2014,45(1):78-86.

[49] 李美君,方成堃,张凯,等.饲粮中添加乳铁蛋白对早期断奶仔猪生长性能、肠道菌群及肠黏膜形态的影响[J].动物营养学报,2012,24(1):111-116.

[50] 肖定福,唐志如,印遇龙,等.壳聚糖对仔猪肠黏膜通透性及Occludin和ZO-1表达的影响[J].畜牧兽医学报,2012,43(6):894-900.
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