[1] PETERS T,AUSMEIER K,RVTHER U.Cloning of Fatso (
Fto),a novel gene deleted by the Fused toes (
Ft) mouse mutation[J].Mammalian Genome,1999,10(10):983-986.
[2] GÖTZ K,BRISCOE J,RVTHER U.Homozygous
Ft embryos are affected in floor plate maintenance and ventral neural tube patterning[J].Developmental Dynamics,2005,233(2):623-630.
[3] HEYMER J,KUEHN M,RÜTHER U.The expression pattern of
nodal and
lefty in the mouse mutant
Ft suggests a function in the establishment of handedness[J].Mechanisms of Development,1997,66(1/2):5-11.
[4] GROTEWOLD L,RÜTHER U.The Fused toes (
Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly[J].Developmental Biology,2002,251(1):129-141.
[5] VAN DER HOEVEN F,SCHIMMANG T,VOLKMANN A,et al.Programmed cell death is affected in the novel mouse mutant Fused toes (
Ft)[J].Development,1994,120(9):2601-2607.
[6] STRATAKIS C A,LAFFERTY A,TAYMANS S E,et al.Anisomastia associated with interstitial duplication of chromosome 16,mental retardation,obesity,dysmorphic facies,and digital anomalies:molecular mapping of a new syndrome by fluorescent
in situ hybridization and microsatellites to 16q13 (D16S419-D16S503)[J].The Journal of Clinical Endocrinology and Metabolism,2000,85(9):3396-3401.
[7] FRAYLING T M,TIMPSON N J,WEEDON M N,et al.A common variant in the
FTO gene is associated with body mass index and predisposes to childhood and adult obesity[J].Science,2007,316(5826):889-894.
[8] FAN B,DU Z Q,ROTHSCHILD M F.The fat mass and obesity-associated (
FTO) gene is associated with intramuscular fat content and growth rate in the pig[J].Animal Biotechnology,2009,20(2):58-70.
[9] MÜLLER T D,HINNEY A,SCHERAG A,et al.Fat mass and obesity associated gene (
FTO):no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents[J].BMC Medical Genetics,2008,9(1):85.
[10] STRATIGOPOULOS G,PADILLA S L,LEDUC C A,et al.Regulation of
Fto/Ftm gene expression in mice and humans[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2008,294(4):R1185-R1196.
[11] BOISSEL S,REISH O,PROULX K,et al.Loss-of-function mutation in the dioxygenase-encoding
FTO gene causes severe growth retardation and multiple malformations[J].The American Journal of Human Genetics,2009,85(1):106-111.
[12] GERKEN T,GIRARD C A,TUNG Y C L,et al.The obesity-associated
FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase[J].Science,2007,318(5855):1469-1472.
[13] JIA G,YANG C G,YANG S,et al.Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human
FTO[J].FEBS Letters,2008,582(23/24):3313-3319.
[14] SANCHEZ-PULIDO L,ANDRADE-NAVARRO M A.The
FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily[J].BMC Biochemistry,2007,8(1):23.
[15] KUROWSKI M A,BHAGWAT A S,PAPAJ G,et al.Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB[J].BMC Genomics,2003,4(1):48.
[16] WESTBYE M P,FEYZI E,AAS P A,et al.Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA[J].The Journal of Biological Chemistry,2008,283(36):25046-25056.
[17] FU Y,DAI Q,ZHANG W,et al.The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA[J].Angewandte Chemie International Edition,2010,49(47):8885-8888.
[18] VAN DEN BORN E,VÅGBØ C B,SONGE-MØLLER L,et al.ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA[J].Nature Communications,2011,2(2):172.
[19] HAN Z F,NIU T H,CHANG J B,et al.Crystal structure of the
FTO protein reveals basis for its substrate specificity[J].Nature,2010,464(7292):1205-1209.
[20] JIA G F,FU Y,ZHAO X,et al.N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated
FTO[J].Nature Chemical Biology,2011,7(12):885-887.
[21] WU Q,SAUNDERS R A,SZKUDLAREK-MIKHO M,et al.The obesity-associated
Fto gene is a transcriptional coactivator[J].Biochemical and Biophysical Research Communications,2010,401(3):390-395.
[22] LEIN E S,HAWRYLYCZ M J,AO N,et al.Genome-wide atlas of gene expression in the adult mouse brain[J].Nature,2007,445(7124):168-176.
[23] MORTON G J,CUMMINGS D E,BASKIN D G,et al.Central nervous system control of food intake and body weight[J].Nature,2006,443(7109):289-295.
[24] FREDRIKSSON R,HÄGGLUND M,OLSZEWSKI P K,et al.The obesity gene,
FTO,is of ancient origin,up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain[J].Endocrinology,2008,149(5):2062-2071.
[25] SÉBERT S P,HYATT M A,CHAN L L Y,et al.Influence of prenatal nutrition and obesity on tissue specific fat mass and obesity-associated (
FTO) gene expression[J].Reproduction,2010,139(1):265-274.
[26] TUNG Y C L,AYUSO E,SHAN X Y,et al.Hypothalamic-specific manipulation of Fto,the ortholog of the human obesity gene
FTO,affects food intake in rats[J].PLoS One,2010,5(1):e8771.
[27] FISCHER J,KOCH L,EMMERLING C,et al.Inactivation of the
Fto gene protects from obesity[J].Nature,2009,458(7240):894-898.
[28] CHURCH C,MOIR L,MCMURRAY F,et al.Overexpression of
Fto leads to increased food intake and results in obesity[J].Nature Genetics,2010,42(12):1086-1092.
[29] TIWARI A,KRZYSIK-WALKER S M,RAMACHANDRAN R.Cloning and characterization of chicken fat mass and obesity associated (
Fto) gene:fasting affects
Fto expression[J].Domestic Animal Endocrinology,2012,42(1):1-10.
[30] YUAN L X,NI Y D,BARTH S,et al.Layer and broiler chicks exhibit similar hypothalamic expression of orexigenic neuropeptides but distinct expression of genes related to energy homeostasis and obesity[J].Brain Research,2009,1273:18-28.
[31] DINA C,MEYRE D,GALLINA S,et al.Variation in
FTO contributes to childhood obesity and severe adult obesity[J].Nature Genetics,2007,39(6):724-726.
[32] HINNEY A,NGUYEN T T,SCHERAG A,et al.Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (
FTO) variants[J].PLoS One,2007,2(12):e1361.
[33] SCUTERI A,SANNA S,CHEN W M,et al.Genome-wide association scan shows genetic variants in the
FTO gene are associated with obesity-related traits[J].PLoS Genetics,2007,3(7):e115.
[34] CECIL J E,TAVENDALE R,WATT P,et al.An obesity-associated
FTO gene variant and increased energy intake in children[J].The New England Journal of Medicine,2008,359(24):2558-2566.
[35] HAUPT A,THAMER C,STAIGER H,et al.Variation in the
FTO gene influences food intake but not energy expenditure[J].Experimental and Clinical Endocrinology & Diabetes,2009,117(4):194-197.
[36] SONESTEDT E,ROOS C,GULLBERG B,et al.Fat and carbohydrate intake modify the association between genetic variation in the
FTO genotype and obesity[J].The American Journal of Clinical Nutrition,2009,90(5):1418-1425.
[37] WARDLE J,LLEWELLYN C,SANDERSON S,et al.The
FTO gene and measured food intake in children[J].International Journal of Obesity,2009,33(1):42-45.
[38] WÀHLÉN K,SJÖLIN E,HOFFSTEDT J.The common
rs9939609 gene variant of the fat mass- and obesity-associated gene
FTO is related to fat cell lipolysis[J].The Journal of Lipid Research,2008,49(3):607-611.
[39] TEWS D,FISCHER-POSOVSZKY P,WABITSCH M.Regulation of
FTO and
FTM expression during human preadipocyte differentiation[J].Hormone and Metabolic Research,2011,43(1):17-21.
[40] 王玉峰.鸡
FTO基因:组织特异性表达、中枢核团定位、品种差异以及禁食的影响[D].硕士学位论文.南京:南京农业大学,2009.
[41] BRUGGEMAN V,ONAGBESAN O M,DECUYPERE E.Body weight,fat content,liver weight and plasma leptin concentrations in broiler breeder females reared under ad libitum feeding,restricted feeding or combinations of both until age of first egg[J].British Poultry Science,2000,41(S1):57-59.
[42] TAOUIS M,DRIDI S,CASSY S,et al.Chicken leptin:properties and actions[J].Domestic Animal Endocrinology,2001,21(4):319-327.
[43] JIA X,NIE Q,LAMONT S J,et al.Variation in sequence and expression of the avian
FTO,and association with glucose metabolism,body weight,fatness and body composition in chickens[J].International Journal of Obesity,2012,36(8):1054-1061.
[44] FONTANESI L,SCOTTI E,BUTTAZZONI L,et al.The porcine fat mass and obesity associated (
FTO) gene is associated with fat deposition in Italian Duroc pigs[J].Animal Genetics,2009,40(1):90-93.
[45] RENSTRÖM F,PAYNE F,NORDSTRÖM A,et al.Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden[J].Human Molecular Genetics,2009,18(8):1489-1496.
[46] ZHANG L F,MIAO X T,HUA X C,et al.Polymorphism in 5' regulatory region of the porcine fat mass and obesity associated (
FTO) gene is associated with intramuscular fat content in a Jinhua x Pietrain F2 reference population[J].Journal of Animal and Veterinary Advances,2009,8(11):2329-2334.
[47] 郭兵.猪FTO的组织特异性表达及其调控[D].硕士学位论文.南京:南京农业大学,2010.
[48] MADSEN M B.猪肥胖症候选基因
FTO的表达研究[J].晋大鹏,译.中国畜牧兽医,2010(5):146-146.
[49] REMPEL L A,CASAS E,SHACKELFORD S D,et al.Relationship of polymorphisms within metabolic genes and carcass traits in crossbred beef cattle[J].Journal of Animal Science,2012,90(4):1311-1316.
[50] ZHANG B,ZHANG Y,ZHANG L Z,et al.Allelic polymorphism detected in the bovine
FTO gene[J].Molecular Biotechnology,2011,49(3):257-262.
[51] WEI S J,ZAN L S,UJAN J A,et al.Novel polymorphism of the bovine fat mass and obesity-associated (
FTO) gene are related to backfat thickness and longissimus muscle area in five Chinese native cattle breeds[J].African Journal of Biotechnology,2011,10(15):2820-2824.
[52] 刘建,阎萍,梁春年,等.牛
FTO基因功能结构生物信息学分析[C]//中国畜牧兽医学会养牛学分会2011年学术研讨会文集.北京:中国畜牧兽医学会,2011.
