[1] POLIAKOV E,GENTLEMAN S,CUNNINGHAM F X,et al.Key role of conserved histidines in recombinant mouse β-carotene 15,15'-mono-oxygenase-1 activity[J].The Journal of Biological Chemistry,2005,280(32):29217-29223.

[2] KLOER D P,SCHULZ G E.Structural and biological aspects of carotenoid cleavage[J].Cellular and Molecular Life Sciences,2006,63(19/20):2291-2303.
[3] LIETZ G,LANGE J,RIMBACH G.Molecular and dietary regulation of β,β-carotene 15,15'-monooxygenase 1 (BCMO1)[J].Archives of Biochemistry and Biophysics,2010,502(1):8-16.

[4] HESSEL S,EICHINGER A,ISKEN A,et al.CMO1 deficiency abolishes vitamin A production from β-carotene and alters lipid metabolism in mice[J].The Journal of Biological Chemistry,2007,282(46):33553-33561.

[5] AMENGUAL J,GOURANTON E,VAN HELDEN Y G J,et al.Beta-carotene reduces body adiposity of mice via BCMO1[J].PLoS One,2011,6:e20644.
[6] OLSON J A.Provitamin A function of carotenoids:the conversion of β-carotene into vitamin A[J].Journal of Nutrition,1989,119:105-108.
[7] WANG X D,RUSSELL R M,LIU C,et al.β-Oxidation in rabbit liver
in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from β-apocarotenoic acids[J].The Journal of Biological Chemistry,1996,271(43):26490-26498.

[8] WOLF G,PHIL D.The enzymatic cleavage of β-carotene:still controversial[J].Nutrition Reviews,1995,53(5):134-137.
[9] WYSS A.Carotene oxygenases:a new family of double bond cleavage enzymes[J].The Journal of Nutrition,2004,134(1):246S-250S.
[10] SHMARAKOV I,FLESHMAN M K,D'AMBROSIO D N,et al.Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid[J].Archives of Biochemistry and Biophysics,2010,504(1):3-10.

[11] VOGEL J T,TAN B C,MCCARTY D R,et al.The carotenoid cleavage dioxygenase 1 enzyme has broad substrate specificity,cleaving multiple carotenoids at two different bond positions[J].The Journal of Biological Chemistry,2008,283(17):11364-11373.

[12] AMENGUAL J,WIDJAJA-ADHI M A K,RODRIGUEZ-SANTIAGO S,et al.Two carotenoid oxygenases contribute to mammalian provitamin A metabolism[J].The Journal of Biological Chemistry,2013,288(47):34081-34096.

[13] SHE H Y,XIONG S G,HAZRA S,et al.Adipogenic transcriptional regulation of hepatic stellate cells[J].The Journal of Biological Chemistry,2005,280(6):4959-4967.

[14] AMENGUAL J,LOBO G P,GOLCZAK M,et al.A mitochondrial enzyme degrades carotenoids and protects against oxidative stress[J].The FASEB Journal,2011,25(3):948-959.

[15] LOBO G P,ISKEN A,HOFF S,et al.BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway[J].Development,2012,139(16):2966-2977.

[16] YU D N,DOS SANTOS C O,ZHAO G W,et al.miR-451 protects against erythroid oxidant stress by repressing 14-3-3ζ[J].Genes & Development,2010,24(15):1620-1633.

[17] VON LINTIG J,HESSEL S,ISKEN A,et al.Towards a better understanding of carotenoid metabolism in animals[J].Biochimica et Biophysica Acta (BBA):Molecular Basis of Disease,2005,1740(2):122-131.

[18] WIRTZ G M,BORNEMANN C,GIGER A,et al.The substrate specificity of β,β-carotene 15,15' -monooxygenase[J].Helvetica Chimica Acta,2001,84(8):2301-2315.

[19] Kim Y S,OH D K.Substrate specificity of a recombinant chicken β-carotene 15,15'-monooxygenase that converts β-carotene into retinal[J].Biotechnology Letters,2009,31(3):403-408.

[20] KIEFER C,HESSEL S,LAMPERT J M,et al.Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A[J].Journal of Biological Chemistry,2001,276(17):14110-14116.
[21] MEIN J R,DOLNIKOWSKI G G,ERNST H,et al.Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein,zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase[J].Archives of Biochemistry and Biophysics,2011,506(1):109-121.

[22] DUSZKA C,GROLIER P,AZIM E M,et al.Rat intestinal β-carotene dioxygenase activity is located primarily in the cytosol of mature jejunal enterocytes[J].Journal of Nutrition,1996,126:2550-2556.
[23] LINDQVIST A,ANDERSSON S.Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase[J].Journal of Biological Chemistry,2002,277(26):23942-23948.

[24] LINDQVIST A,ANDERSSON S.Cell type-specific expression of β-carotene 15,15'-mono-oxygenase in human tissues[J].Journal of Histochemistry & Cytochemistry,2004,52(4):491-499.

[25] LINDQVIST A,HE Y G,ANDERSSON S.Cell type-specific expression of β-carotene-9',10' -monooxygenase in human tissues[J].Journal of Histochemistry & Cytochemistry,2005,53(11):1403-1412.

[26] LUVIZOTTO R A,NASCIMENTO A F,VEERAMACHANENI S,et al.Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats[J].The Journal of Nutrition,2010,140(10):1808-1814.

[27] KIM Y K,WASSEF L,CHUNG S,et al.β-carotene and its cleavage enzyme β-carotene 15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues[J].The FASEB Journal,2011,25(5):1641-1652.

[28] ZIOUZENKOVA O,ORASANU G,SHARLACH M,et al.Retinaldehyde represses adipogenesis and diet-induced obesity[J].Nature Medicine,2007,13(6):695-702.

[29] MANTENA S K,KING A L,ANDRINGA K K,et al.Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases[J].Free Radical Biology and Medicine,2008,44(7):1259-1272.

[30] LAKSHMAN M R,LIU Q H,SAPP R,et al.The effects of dietary taurocholate,fat,protein,and carbohydrate on the distribution and fate of dietary β-carotene in ferrets[J].Nutrition and Cancer,1996,26(1):49-61.

[31] HOSOTANI K,KITAGAWA M.Effects of dietary protein,fat and beta-carotene levels on beta-carotene absorption in rats[J].International Journal for Vitamin and Nutrition Research,2005,75(4):274-280.

[32] BOULANGER A,MCLEMORE P,COPELAND N G,et al.Identification of beta-carotene 15,15'-monooxygenase as a peroxisome proliferator-activated receptor target gene[J].The FASEB Journal,2003,17(10):1304-1306.
[33] GONG X,TSAI S W,YAN B,et al.Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression[J].BMC Molecular Biology,2006,7:7.
[34] ZARIPHEH S,NARA T Y,NAKAMURA M T,et al.Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues[J].The Journal of Nutrition,2006,136(4):932-938.
[35] SEINO Y,MIKI T,KIYONARI H,et al.ISX participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15,15'-monooxygenase (BCMO1) expression[J].The Journal of Biological Chemistry,2008,283(8):4905-4911.

[36] LOBO G P,HESSEL S,EICHINGER A,et al.ISX is a retinoic acid-sensitive gatekeeper that controls intestinal β,β-carotene absorption and vitamin A production[J].The FASEB Journal,2010,24(6):1656-1666.

[37] LINDQVIST A,SHARVILL J,SHARVILL D E,et al.Loss-of-function mutation in carotenoid 15,15'-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A[J].The Journal of Nutrition,2007,137(11):2346-2350.
[38] POLIAKOV E,GENTLEMAN S,CHANDER P,et al.Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse β-carotene 15,15'-monooxygenase [J].BMC Biochemistry,2009,10:31.
[39] TIAN R,PITCHFORD W S,MORRIS C A,et al.Genetic variation in the β,β-carotene-9',10'-dioxygenase gene and association with fat colour in bovine adipose tissue and milk[J].Animal Genetics,2010,41(3):253-259.

[40] VÅGE D I,BOMAN I A.A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (
Ovis aries)[J].BMC Genetics,2010,11:10.
[41] ERIKSSON J,LARSON G,GUNNARSSON U,et al.Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken[J].PLoS Genetics,2008,4(2):e1000010.