miR-21: Biogenesis, Expression Regulations and Its Role in Regulating Apoptosis

PENG Han; QI Renli; HUANG Jinxiu; CHEN Ying; LIU Yan; LIU Zuohua

doi:10.3969/j.issn.1006-267x.2014.12.007

Chinese Journal of Animal Nutrition >

2014 , Vol. 26 >Issue 12: 3593 - 3598

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.12.007

Review

miR-21: Biogenesis, Expression Regulations and Its Role in Regulating Apoptosis

PENG Han ,
QI Renli ,
HUANG Jinxiu ,
CHEN Ying ,
LIU Yan ,
LIU Zuohua

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1. Southwest University, Rongchang Campus, Rongchang 402460, China;
2. Chongqing Academy of Animal Sciences, Rongchang 402460, China

Received date: 2014-06-23

Online published: 2014-12-05

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Abstract

Apoptosis is a basic biological phenomenon, which plays a key role in physiological and pathological process. miRNAs are a small class of endogenous non-coding, single-stranded RNA of about 22 nucleotides in length, which are found in eukaryotes, and can regulate cell apoptosis, differentiation, proliferation, invasion and metabolism via regulating expression of target gene. Particularly, as one of miRNAs, miR-21 and its function in regulating cell apoptosis has been reported in extensive studies. This paper reviewed the biogenesis and expression regulations of miR-21and its role in regulating apoptosis.

Key words： miR-21; expression and regulation; apoptosis

Cite this article

PENG Han , QI Renli , HUANG Jinxiu , CHEN Ying , LIU Yan , LIU Zuohua . miR-21: Biogenesis, Expression Regulations and Its Role in Regulating Apoptosis[J]. Chinese Journal of Animal Nutrition, 2014 , 26(12) : 3593 -3598 . DOI: 10.3969/j.issn.1006-267x.2014.12.007

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