Review

Immune Regulation Roles of Phytogenic Polysaccharides and Its Mechanisms

  • SHANG Qinghui ,
  • XIE Yuhuai ,
  • ZHANG Guiguo ,
  • JIANG Shuzhen ,
  • YANG Zaibin ,
  • YANG Weiren ,
  • ZHANG Chongyu
Expand
  • College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China

Received date: 2014-08-04

  Online published: 2015-01-10

Abstract

Polysaccharides, a kind of natural macromolecule, is widespread occurrence in biological bodies and has many kinds of biological activities, which plays an important role in regulating immune system. Previous studies documented that phytogenic polysaccharides could regulate animals' immune system by combining to membrane receptors of immune cells and initiating the special signaling pathways. This included stimulating the secretion or proliferation of macrophages, T/B lymphocytes and natural killer (NK) cells, modulating the release of cytokines, promoting the production of antibodies, and activating the complement system, etc. This paper mainly reviews the immune regulation roles of phytogenic polysaccharides and related molecular mechanisms.

Cite this article

SHANG Qinghui , XIE Yuhuai , ZHANG Guiguo , JIANG Shuzhen , YANG Zaibin , YANG Weiren , ZHANG Chongyu . Immune Regulation Roles of Phytogenic Polysaccharides and Its Mechanisms[J]. Chinese Journal of Animal Nutrition, 2015 , 27(1) : 49 -58 . DOI: 10.3969/j.issn.1006-267x.2015.01.008

References

[1] 何朝勇,王立为.多糖的免疫调节作用综述[J].安徽中医学院学报,2002,21(4):62-64.

[2] ROUT D,MONDAL S,CHAKRABORTY I,et al.Chemical analysis of a new (1→3)-,(1→6)-branched glucan from an edible mushroom,Pleurotus florida[J].Carbohydrate Research,2005,340(16):2533-2539.  

[3] HAN S B,YOON Y D,AHN H J,et al.Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus[J].International Immunopharmacology,2003,3(9):1301-1312.  

[4] 邹云,谢红兵,禹琪芳,等.植物多糖对断奶仔猪淋巴细胞增殖和细胞因子分泌的影响[J].动物营养学报,2014,26(1):210-218.

[5] 章世元,徐春燕,董晓芳,等.苜蓿多糖和黄芪多糖对肉仔鸡淋巴细胞增殖的影响[J].动物营养学报,2010,22(3):670-674.

[6] KIM H S,KIM Y J,LEE H K,et al.Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4[J].Food and Chemical Toxicology,2012,50(9):3190-3197.  

[7] 李敬双,刘英姿,唐雨顺,等.苜蓿多糖对小鼠淋巴细胞增殖和NK细胞活性影响的研究[J].中国农学通报,2012,28(32):89-93.

[8] 徐贤柱,饶华,蔡险峰,等.杜仲叶多糖提取及对小鼠免疫功能影响研究[J].时珍国医国药,2013(3):541-542.

[9] GLOVSKY M M,CORTES-HAENDCHEN L,GHEKIERE L,et al.Effects of particulate beta-1,3 glucan on human, rat, and guinea pig complement activity[J].Journal of the Reticuloendothelial Society,1983,33(5):401-413.

[10] SCHEPETKIN I A,QUINN M T.Botanical polysaccharides:macrophage immunomodulation and therapeutic potential[J].International Immunopharmacology,2006,6(3):317-333.  

[11] 程安玮,金征宇,万发春,等.甘草多糖对小鼠腹腔巨噬细胞化学成分及胞内酶的影响[J].食品与生物技术学报,2008,27(1):76-79.

[12] 尹美珍,阮启刚,余桂朋,等.艾叶多糖对体外培养巨噬细胞吞噬功能的影响[J].时珍国医国药,2012,23(1):162-163.

[13] YU Q,NIE S P,LI W J,et al.Macrophage immunomodulatory activity of a purified polysaccharide isolated from Ganoderma atrum[J].Phytotherapy Research,2013,27(2):186-191.  

[14] 王德成,单风平.牛膝多糖对小鼠腹腔巨噬细胞的活化作用[J].微生物学杂志,2013,33(4):59-61.

[15] HUANG M,MEI X,ZHANG S.Mechanism of nitric oxide production in macrophages treated with medicinal mushroom extracts (review)[J].International Journal of Medicinal Mushrooms,2011,13(1): 1-6.  

[16] 荣岳光.苜草素对小鼠巨噬细胞NO,IL-6,TNF-α分泌的影响及其机理研究[D].硕士学位论文.北京:中国农业科学院,2007.

[17] LEE K Y,JEON Y J.Polysaccharide isolated from Poria cocos sclerotium induces NF-κB/Rel activation and iNOS expression in murine macrophages[J].International Immunopharmacology,2003,3(10):1353-1362.

[18] 黄海华.药学细胞生物学[M].北京:中国医药科技出版社,2006:208.

[19] 郭仁强.临床免疫学基础[M].南京:江苏科学出版社,1982:72-86.

[20] 尹美珍,胡岗,李仲娟,等.艾叶多糖对小鼠腹腔巨噬细胞内酶活性的影响[J].时珍国医国药,2013,24(9):2118-2120.

[21] 王青,胡明华,董燕,等.茯苓多糖对免疫抑制小鼠粘膜淋巴组织及脾脏中CD3+和 CD19+细胞变化的影响[J].中国免疫学杂志,2011,27(3):228-231.

[22] 罗强,任鸿,孙黎,等.刺五加多糖对小鼠淋巴细胞转化率及外周血淋巴细胞亚群的影响[J].河南农业科学,2013,42(8):137-140.

[23] HUANG Y,JIANG C,HU Y,et al.Immunoenhancement effect of rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell[J].Carbohydrate Polymers,2013,96(2):516-521.  

[24] 刘亚娟,陈赛娟,李海丽,等.枸杞多糖对生长獭兔生产性能及血清生化指标的影响[J].中国饲料,2013(20):22-25.

[25] RAULET D H.Missing self recognition and self tolerance of natural killer (NK) cells[J].Seminars in Immunology,2006,18(3):145-150.  

[26] 余英才,张纯,夏循礼,等.补体系统的进化[J].生命科学,2012,24(004):362-367.

[27] 马红樱,张德禄,胡春香,等.植物活性多糖的研究进展[J].西北师范大学学报:自然科学版,2004,40(3):112-117.

[28] ROEDER A,KIRSCHNING C J,RUPEC R A,et al.Toll-like receptors as key mediators in innate antifungal immunity[J].Medical Mycology,2004,42(6):485-498.  

[29] 吴燕燕,王易.Toll样受体信号通路中MyD88的研究进展[J].免疫学杂志,2012,28(3):262-265.

[30] WIDMANN C,GIBSON S,JARPE M B,et al.Mitogen-activated protein kinase:conservation of a three-kinase module from yeast to human[J].Physiological Reviews,1999,79(1):143-180.

[31] LEE K Y,YOU H J,JEONG H G,et al.Polysaccharide isolated from Poria cocos sclerotium induces NF-κB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages[J].International Immunopharmacology,2004,4(8):1029-1038.  

[32] GHOSH S,MAY M J,KOPP E B.NF-κB and Rel proteins:evolutionarily conserved mediators of immune responses[J].Annual Review of Immunology,1998,16(1):225-260.  

[33] LI Q,VERMA I M.NF-κB regulation in the immune system[J].Nature Reviews Immunology,2002,2(10):725-734.  

[34] LI X,XU W.TLR4-mediated activation of macrophages by the polysaccharide fraction from Polyporus umbellatus (pers.) fries[J].Journal of Ethnopharmacology,2011,135(1):1-6.  

[35] WRIGHT S D,RAMOS R A,TOBIAS P S,et al.CD14,a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein[J].Science,1990,249(4975):1431-1433.  

[36] ROSS G D,VETVIVKA V.CR3 (CD11b,CD18):a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions[J].Clinical and Experimental Immunology,1993,92(2):181-184.

[37] ZAREWYCH D M,KINDZELSKII A L,TODD R F,et al.LPS induces CD14 association with complement receptor type 3,which is reversed by neutrophil adhesion[J].The Journal of Immunology,1996,156(2):430-433.

[38] MORK A C,SUN X,LIU X B,et al.Regulation of (1-3)-β-glucan-stimulated Ca2+ influx by protein kinase C in NR8383 alveolar macrophages[J].Journal of Cellular Biochemistry,2000,78(1):131-140.  

[39] HAN S B,PARK S H,LEE K H,et al.Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells[J].International Immunopharmacology,2001,1(11):1969-1978.  

[40] GAZI U,MARTINEZ-POMARES L.Influence of the mannose receptor in host immune responses[J].Immunobiology,2009,214(7):554-561.  

[41] STEINMAN R M,MELLMAN I S,MULLER W A,et al.Endocytosis and the recycling of plasma membrane[J].The Journal of Cell Biology,1983,96(1):1-27.  

[42] 郭振军,刘莉,张维璐,等.大黄、当归多糖对巨噬细胞甘露糖受体作用的研究[J].细胞与分子免疫学杂志,2008,24(5):514-516.

[43] MURPHY J E,TEDBURY P R,HOMER-VANNIASINKAM S,et al.Biochemistry and cell biology of mammalian scavenger receptors[J].Atherosclerosis,2005,182(1):1-15.  

[44] 金伯泉.医学免疫学[M].5版.北京:人民卫生出版社,2008:137.

[45] ILCHMANN A,BURGDORF S,SCHEURER S,et al.Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity:role of macrophage scavenger receptor class A type Ⅰ and Ⅱ[J].Journal of Allergy and Clinical Immunology,2010,125(1):175-183.  

[46] NAKAMURA T,SUZUKI H,WADA Y,et al.Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-κB-dependent signaling pathways through macrophage scavenger receptors[J].Biochemical and Biophysical Research Communications,2006,343(1):286-294.  

[47] BROWN G D,GORDON S.Immune recognition:a new receptor for β-glucans[J].Nature,2001,413(6851):36-37.

[48] HERRE J,MARSHALL A S,CARON E,et al.Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages[J].Blood,2004,104(13):4038-4045.  

[49] GUO L,XIE J,RUAN Y,et al.Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum[J].International Immunopharmacology,2009,9(10):1175-1182.  

[50] 易阳,曹银,张名位.多糖调控T/B淋巴细胞免疫应答机制的研究进展[J].中国细胞生物学学报,2012,34(1):67-74.

[51] SHAO B,XU W,DAI H,et al.A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb[J].Biochemical and Biophysical Research Communications,2004,320(4):1103-1111.  

[52] MATSUMOTO T,HOSONO-NISHIYAMA K,GUO Y,et al.A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of Bupleurum falcatum L. in murine B cell[J].International Immunopharmacology,2005,5(9):1373-1386.  

[53] TINGJUN H,RONGLIANG Z.Promotion of Sophora subprosrate polysaccharide on nitric oxide and interleukin-2 production in murine T lymphocytes:implicated Ca2+ and protein kinase C[J].International Immunopharmacology,2004,4(1):109-118.  

[54] CHEN Z,KWONG HUAT TAN B,CHAN S H.Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L.[J].International Immunopharmacology,2008,8(12):1663-1671.  

[55] HAMURO J,HADDING U,BITTER-SUERMANN D.Solid phase activation of alternative pathway of complement by beta-1,3-glucans and its possible role for tumour regressing activity[J].Immunology,1978,34(4):695-705.

[56] RAVEENDRAN NAIR P K,RODRIGUEZ S,RAMACHANDRAN R,et al.Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia[J].International Immunopharmacology,2004,4(13):1645-1659.  
Outlines

/