[1] GALLINETTI J,HARPUTLUGIL E,MITCHELL J R.Amino acid sensing in dietary-restriction-mediated longevity:roles of signal-transducing kinases GCN2 and TOR[J].Biochemical Journal,2013,449(1):1-10.
[2] 吕子全,郭非凡.氨基酸感应与糖脂代谢调控的研究进展[J].生命科学,2013,25(2):152-157.
[3] POLAK P,HALL M N.mTOR and the control of whole body metabolism[J].Current Opinion in Cell Biology,2009,21(2):209-218.
[4] WULLSCHLEGGER S,LOEWITH R,HALL M N.TOR signaling in growth and metabolism[J].Cell,2006,124(3):471-484.
[5] KIM J,GUAN K L.Amino acid signaling in TOR activation[J].Annual Review of Biochemistry,2011,80:1001-1032.
[6] LOEWITH R,JACINTO E,WULLSCHLEGER S,et al.Two TOR complexes,only one of which is rapamycin sensitive,have distinct roles in cell growth control[J].Molecular Cell,2002,10(3):457-468.
[7] ZINZALLA V,STRACKA D,OPPLIGER W,et al.Activation of mTORC2 by association with the ribosome[J].Cell,2011,144(5):757-768.
[8] LAPLANTE M,SABATINI D M.mTOR signaling in growth control and disease[J].Cell,2012,149(2):274-293.
[9] CYBULSKI N,HALL M N.TOR complex 2:a signaling pathway of its own[J].Trends in Biochemical Sciences,2009,34(12):620-627.
[10] HAGIWARA A,CORNU M,CYBULSKI N,et al.Hepatic mTORC2 activates glycolysis and lipogenesis through Akt,glucokinase,and SREBP1c[J].Cell Metabolism,2012,15(5):725-738.
[11] SEILIEZ I,GABILLARD J C,SKIBA-CASSY S,et al.An
in vivo and
in vitro assessment of TOR signaling cascade in rainbow trout (
Oncorhynchus mykiss)[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2008,295(1):R329-R335.
[12] BHASKAR P T,HAY N.The two TORCs and AKT[J].Developmental Cell,2007,12(4):487-502.
[13] KIM E,GORAKSHA-HICKS P,LI L,et al.Regulation of TORC1 by Rag GTPases in nutrient response[J].Nature Cell Biology,2008,10(8):935-945.
[14] SANCAK Y,BAR-PELED L,ZONCU R,et al.Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids[J].Cell,2010,141(2):290-303.
[15] SANCAK Y,PETERSON T R,SHAUL Y D,et al.The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1[J].Science,2008,320(5882):1496-1501.
[16] JEWELL J L,RUSSELL R C,GUAN K L.Amino acid signalling upstream of mTOR[J].Nature Reviews Molecular Cell Biology,2013,14(3):133-139.
[17] SEILIEZ I,PANSERAT S,LANSARD M,et al.Dietary carbohydrate-to-protein ratio affects TOR signaling and metabolism-related gene expression in the liver and muscle of rainbow trout after a single meal[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2011,300(3):733-743.
[18] HARA K,YONEZAWA K,WENG Q P,et al.Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism[J].Journal of Biological Chemistry,1998,273(23):14484-14494.
[19] KIMBALL SR,JEFFERSON L S.Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis[J].The Journal of Nutrition,2006,136(1):227S-231S.
[20] STIPANUK M H.Leucine and protein synthesis:mTOR and beyond[J].Nutrition Reviews,2007,65(3):122-129.
[21] 邓会玲,刘国华,刘宁.氨基酸介导的TOR信号传导通路研究进展[J].动物营养学报,2011,23(4):529-535.
[22] DRUMMOND M J,RASMUSSEN B B.Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis[J].Current Opinion in Clinical Nutrition & Metabolic Care,2008,11(3):222-226.
[23] PESTOVA T V,KOLUPAEVA V G,LOMAKIN I B,et al.Molecular mechanisms of translation initiation in eukaryotes[J].Proceedings of the National Academy of Sciences of the United States of America,2001,98(13):7029-7036.
[24] GEBAUER F,HENTZE M W.Molecular mechanisms of translational control[J].Nature Reviews Molecular Cell Biology,2004,5(10):827-835.
[25] GINGRAS A C,KENNEDY S G,O'LEARY M A,et al.4E-BP1,a repressor of mRNA translation,is phosphorylated and inactivated by the Akt (PKB) signaling pathway[J].Genes Development,1998,12(4):502-513.
[26] JASTRZEBSKI K,HANNAN K M,TCHOUBRIEVA E B,et al.Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase,a key mediator of mTOR function[J].Growth Factors,2007,25(4):209-226.
[27] RUVINSKY I,SHARON N,LERER T,et al.Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis[J].Genes Development,2005,19(18):2199-2211.
[28] RUVINSKY I,MEYUHAS O.Ribosomal protein S6 phosphorylation:from protein synthesis to cell size[J].Trends in Biochemical Sciences,2006,31(6):342-348.
[29] JEFFERIES H B,FUMAGALLI S,DENNIS P B,et al.Rapamycin suppresses 5' TOP mRNA translation through inhibition of p70S6K[J].The EMBO Journal,1997,16(12):3693-3704.
[30] HORNSTERN E,TANG H,MEYUHAS O.Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs[C]//Cold spring harbor symposia on quantitative biology.Cold Spring Harbor,NY:Cold Spring Harbor Laboratory Press,2001:477-484.
[31] MEYUHAS O,AVNI D,SHAMA S.Translational control of ribosomal protein mRNAs in eukaryotes[M].Cold Spring Harbor,NY:Cold Spring Harbor Laboratory Press,1996:363-364.
[32] LECKER S H,JAGOE R T,GILBERT A,et al.Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression[J].The FASEB Journal,2004,18(1):39-51.
[33] HOCHSTRASSER M.Ubiquitin-dependent protein degradation[J].Annual Review of Genetics,1996,30(1):405-439.
[34] MARTIN S A M,BLANEY S,BOWMAN A B,et al.Ubiquitin-proteasome-dependent proteolysis in rainbow trout (
Oncorhynchus mykiss):effect of food deprivation[J].Pflügers Archiv,2002,445(2):257-266.
[35] SALEM M,KENNEY P B,REXROAD C E,et al.Microarray gene expression analysis in atrophying rainbow trout muscle:a unique nonmammalian muscle degradation model[J].Physiological Genomics,2007,28(1):33-45.
[36] WANG Y,LI K,HAN H,et al.Potential of using a blend of rendered animal protein ingredients to replace fish meal in practical diets for malabar grouper (
pinephelus malabricus)[J].Aquaculture,2008,281(1):113-117.
[37] STRAUS D S.Nutritional regulation of hormones and growth factors that control mammalian growth[J].The FASEB Journal,1994,8(1):6-12.
[38] DUAN C M,REN H X,GAO S.Insulin-like growth factors (IGFs),IGF receptors,and IGF-binding proteins:roles in skeletal muscle growth and differentiation[J].General and Comparative Endocrinology,2010,167(3):344-351.
[39] DUVEL K,YECIES J L,MENON S,et al.Activation of a metabolic gene regulatory network downstream of mTOR complex 1[J].Molecular Cell,2010,39(2):171-183.
[40] YECIES J L,MANNING B D.Transcriptional control of cellular metabolism by mTOR signaling[J].Cancer Research,2011,71(8):2815-2820.
[41] ESPENSHADE P J,HUGHES A L.Regulation of sterol synthesis in eukaryotes[J].Genetics,2007,41:401-427.
[42] PORSTMANN T,SANTOS C R,GRIFFITHS B,et al.SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth[J].Cell Metabolism,2008,8(3):224-236.
[43] THOMAS G V,TRAN C,MELLINGHOFF I K,et al.Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer[J].Nature Medicine,2005,12(1):122-127.
[44] MAJMUNDAR A J,WONG W J,SIMON M C.Hypoxia-inducible factors and the response to hypoxic stress[J].Molecular Cell,2010,40(2):294-309.
[45] KIM J W,TCHERNYSHYOV I,SEMENZA G L,et al.HIF-1-mediated expression of pyruvate dehydrogenase kinase:a metabolic switch required for cellular adaptation to hypoxia[J].Cell Metabolism,2006,3(3):177-185.
[46] CUNNINGHAM J T,RODGERS J T,ARLOW D H,et al.mTOR controls mitochondrial oxidative function through a YY1-PGC-1[agr] transcriptional complex[J].Nature,2007,450(7170):736-740.
[47] PENDE M,KOZMA S C,JAQUET M,et al.Hypoinsulinaemia,glucose intolerance and diminished β-cell size in S6K1-deficient mice[J].Nature,2000,408(6815):994-997.
[48] UM S H,FRIGERIO F,WATANABE M,et al.Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity[J].Nature,2004,431(7005):200-205.
[49] LANSARD M,PANSERAT S,PLAGNES-JUAN E,et al.
L-leucine,
L-methionine,and
L-lysine are involved in the regulation of intermediary metabolism-related gene expression in rainbow trout hepatocytes[J].The Journal of Nutrition,2011,141(1):75-80.
[50] LANSARD M,PANSERAT S,PLAGNES-JUAN E,et al.Integration of insulin and amino acid signals that regulate hepatic metabolism-related gene expression in rainbow trout:role of TOR[J].Amino Acids,2010,39(3):801-810.
[51] LANSARD M,PANSERAT S,SEILIEZ I,et al.Hepatic protein kinase B (Akt)-target of rapamycin (TOR)-signalling pathways and intermediary metabolism in rainbow trout (
Oncorhynchus mykiss) are not significantly affected by feeding plant-based diets[J].British Journal of Nutrition,2009,102(11):1564-1573.
[52] SKIBA-CASSY S,PANSERAT S,LARQUIER M,et al.Apparent low ability of liver and muscle to adapt to variation of dietary carbohydrate:protein ratio in rainbow trout (
Oncorhynchus mykiss)[J].British Journal of Nutrition,2013,109(8):1359-1372.
[53] SEILIEZ I,MÉDALE F,AGUIRRE P,et al.Postprandial regulation of growth- and metabolism-related factors in Zebrafish[J].Zebrafish,2013,10(2):237-248.
[54] DAI W W,PANSERAT S,MENNIGEN J A,et al.Post-prandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signalling in rainbow trout (
Oncorhynchus mykiss)[J].Journal of Experimental Biology,2013,216(23):4483-4492.
[55] PADDON-JONES D,SHEFFIELD-MOORE M,ZHANG X J,et al.Amino acid ingestion improves muscle protein synthesis in the young and elderly[J].American Journal of Physiology:Endocrinology and Metabolism,2004,286(3):E321-E328.
[56] KILBERG M S,SHAN J X,SU N.ATF4-dependent transcription mediates signaling of amino acid limitation[J].Trends in Endocrinology and Metabolism,2009,20(9):436-443.
[57] DUDEK S M,SEMENKOVICH C F.Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism[J].Journal of Biological Chemistry,1995,270(49):29323-29329.
[58] CHAVEROUX C,JOUSSE C,CHERASSE Y,et al.Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals[J].Molecular and Cellular Biology,2009,29(24):6515-6526.
[59] MARTEN N,SLADEK F,STRAUS D.Effect of dietary protein restriction on liver transcription factors[J].Biochemical Journal,1996,317(2):361-370.
[60] HAI T,WOLFGANG C D,MARSEE D K,et al.ATF3 and stress responses[J].Gene Expression,1999,7(4/5/6):321-335.
[61] PAN Y X,CHEN H,SIU F,et al.Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that,when overexpressed in HepG2 cells,modulate transcription by the human asparagine synthetase promoter[J].The Journal of Biological Chemistry,2003,278(40):38402-38412.
[62] JIANG H Y,WEK S A,MCGRATH B C,et al.Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response[J].Molecular and Cellular Biology,2004,24(3):1365-1377.
[63] HARDING H P,ZHANG Y,ZENG H,et al.An integrated stress response regulates amino acid metabolism and resistance to oxidative stress[J].Molecular Cell,2003,11(3):619-633.
[64] YE J B,KUMANOVA M,HART L S,et al.The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation[J].The EMBO Journal,2010,29(12):2082-2096.
[65] KIMBALL S R,DO A N D,KUTZLER L,et al.Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis[J].The Journal of Biological Chemistry,2008,283(6):3465-3475.
[66] JIN H O,SEO S K,WOO S H,et al.SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression[J].FEBS Letters,2009,583(1):123-127.
[67] ANTHONY T G,MCDANIEL B J,BYERLEY R L,et al.Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2[J].The Journal of Biological Chemistry,2004,279(35):36553-36561.
[68] GUO F F,CAVENER D R.The GCN2 eIF2α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid[J].Cell Metabolism,2007,5(2):103-114.
[69] DEVAL C,CHAVEROUX C,MAURIN A C,et al.Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways[J].The FEBS Journal,2009,276(3):707-718.
[70] HINNEBUSCH A G.Translational regulation of GCN4 and the general amino Acid control of yeast[J].Annual Review of Microbiology,2005,59:407-450.
[71] KILBERG M S,PAN Y X,CHEN H,et al.Nutritional control of gene expression:how mammalian cells respond to amino acid limitation[J].Annual Review of Nutrition,2005,25:59-85.
[72] ZHANG P C,MCGRATH B C,REINERT J,et al.The GCN2 eIF2α kinase is required for adaptation to amino acid deprivation in mice[J].Molecular and Cellular Biology,2002,22(19):6681-6688.
[73] DE SOUSA-COELHO A L,MARRERO P F,HARO D.Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation[J].Biochemical Journal,2012,443(1):165-171.
[74] ENDO Y,FU Z W,ABE K,et al.Dietary protein quantity and quality affect rat hepatic gene expression[J].The Journal of Nutrition,2002,132(12):3632-3637.
[75] KOEHNLE T J,RUSSELL M C,MORIN A S,et al.Diets deficient in indispensable amino acids rapidly decrease the concentration of the limiting amino acid in the anterior piriform cortex of rats[J].The Journal of Nutrition,2004,134(9):2365-2371.
[76] 郑溜丰,彭健.中枢神经系统整合外周信号调节采食量的分子机制[J].动物营养学报,2013,25(10):2212-2221.
[77] MAURIN A C,JOUSSE C,AVEROUS J,et al.The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores[J].Cell Metabolism,2005,1(4):273-277.
[78] DEVER T E,HINNEBUSCH A G.GCN2 whets the appetite for amino acids[J].Molecular Cell,2005,18(2):141-142.
[79] HAO S Z,SHARP J W,ROSS-INTA C M,et al.Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex[J].Science,2005,307(5716):1776-1778.
[80] LEE J I,DOMINY J E,Jr,SIKALIDIS A K,et al.HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway[J].Physiological Genomics,2008,33(2):218-229.
