Review

Regulation of Host Immune System by Gut Microbiota and Its Possible Mechanisms

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  • Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Institute of Dairy Sciences, Zhejiang University, Hangzhou 310058, China

Received date: 2014-09-22

  Online published: 2015-02-09

Abstract

An animal gut is an open ecological system that is colonized by large numbers and variety of microorganisms. The microbiota has coevolved relationship with the host immune system and plays an important role in maintaining intestinal homeostasis. Establishing and maintaining beneficial interactions between gut microbiota and host immunity are key requirements for host health. Therefore, this article reviewed the composition of gut microbiota, the development of the host immune system under regulation of gut microbes and the possible mechanisms of gut microbiota regulating immune system.

Cite this article

WANG Shanshan, WANG Jiakun, LIU Jianxin . Regulation of Host Immune System by Gut Microbiota and Its Possible Mechanisms[J]. Chinese Journal of Animal Nutrition, 2015 , 27(2) : 375 -382 . DOI: 10.3969/j.issn.1006-267x.2015.02.007

References

[1] The Human Microbiome Project Consortium.Structure, function and diversity of the healthyhuman microbiome[J].Nature,2012,486(7402):207-214.  

[2] QIN J J,LI R Q,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464(7285):59-65.  

[3] CHOI J H,KIM G B,CHA C J.Spatial heterogeneity and stability of bacterial community in the gastrointestinal tracts of broiler chickens[J].Poultry Science,2014,93(8):1942-1950.  

[4] DURSO L M,HARHAY G P,SMITH P L,et al.Animal-to-animal variation in fecal microbial diversity among beef cattle[J].Applied and Environmental Microbiology,2010,76(14):4858-4862.  

[5] DAVE M,HIGGINS P D,MIDDHA S,et al.The human gut microbiome:current knowledge,challenges,and future directions[J].Translational Research,2012,160(4):246-257.  

[6] SEKIROV I,RUSSELL S L,ANTUNES L C,et al.Gut microbiota in health and disease[J].Physiological Reviews,2010,90(3):859-904.  

[7] DOMINGUEZ-BELLO M G,COSTELLO E K,CONTRERAS M,et al.Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(26):11971-11975.  

[8] MOUNTZOURIS K C,MCCARTNEY A L,GIBSON G R.Intestinal microflora of human infants and current trends for its nutritional modulation[J].British Journal of Nutrition,2002,87(5):405-420.

[9] XU J,GORDON J I.Honor thy symbionts[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(18):10452-10459.  

[10] LEY R E,BÄCKHED F,TURNBAUGH P,et al.Obesity alters gut microbial ecology[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(31):11070-11075.  

[11] TURNBAUGH P J,HAMADY M,YATSUNENKO T,et al.A core gut microbiome in obese and lean twins[J].Nature,2009,457(7228):480-484.  

[12] TURNBAUGH P J,BÄCKHED F,FULTON L,et al.Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome[J].Cell Host & Microbe,2008,3(4):213-223.  

[13] DUNCAN S H,BELENGUER A,HOLTROP G,et al.Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces[J].Applied and Environmental Microbiology,2007,73(4):1073-1078.  

[14] ORCUTT R P,GIANNI F J,JUDGE R J.Development of an "altered Schaedler flora" for NCI gnotobiotic rodents[J].Microecology Therapeutics,1987,17:5-9.

[15] NILUSHA M,MEIJU L,LAKSIRI A G,et al.Effect of calf starter feeding on gut microbial diversity and expression of genes involved in host immune responses and tight junctions in dairy calves during weaning transition[J].Journal of Dairy Science,2013,96(5):3189-3200.  

[16] LUNEDO R,FERNANDEZ-ALARCON M F,CARVALLHO F M,et al.Analysis of the intestinal bacterial microbiota in maize- or sorghum-fed broiler chickens using real-time PCR[J].British Poultry Science,2014,55(6):795-803.  

[17] 朱伟云,姚文,毛胜勇.变性梯度凝胶电泳法研究断奶仔猪粪样细菌区系变化[J].微生物学报,2003,43(4):503-508.

[18] JOHANSSON M E V,LARSSON J M,HANSSON G C.The two mucus layers of colon are organized by the MUC2 mucin,whereas the outer layer is a legislator of host-microbial interactions[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(Suppl.1):4659-4665.

[19] ATUMA C,STRUGALA V,ALLEN A,et al.The adherent gastrointestinal mucus gel layer:thickness and physical state in vivo[J].American Journal of Physiology Gastrointest and Liver Physiology,2001,280:G922-G929.

[20] JOHANSSON M E,PHILLIPSON M,PETERSSON J,et al.The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(39):15064-15069.  

[21] AN G Y,WEI B Y,XIA B,et al.Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans[J].Journal of Experimental Medicine,2007,204(6):1417-1429.  

[22] FU J X,WEI B,WEN T,et al.Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice[J].Journal of Clinical Investigation,2011,121(4):1657-1666.  

[23] HEAZLEWOOD C K,COOK M C,ERI R,et al.Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis[J].PLoS Medicine,2008,5(3):e54.

[24] CHELED-SHOVAL S L,GAMAGE N S,AMIT-ROMACH E,et al.Differences in intestinal mucin dynamics between germ-free and conventionally reared chickens after mannan-oligosaccharide supplementation[J].Poultry Science,2014,93(3):636-644.  

[25] SHARMA R,SCHUMACHER U,RONAASEN V,et al.Rat intestinal mucosal responses to a microbial flora and different diets[J].Gut,1995,36(2):209-214.  

[26] PETERSSON J,SCHREIBER O,HANSSON G C,et al.Importance and regulation of the colonic mucus barrier in a mouse model of colitis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2011,300(2):G327-G333.

[27] KOBOZIEV I,KARLSSON F,GRISHAM M B.Gut-associated lymphoid tissue,T cell trafficking,and chronic intestinal inflammation[J].Annals of the New York Academy of Sciences,2010,1207(Suppl.1):e86-e93.

[28] MEBIUS R E.Organogenesis of lymphoid tissues[J].Nature Reviews Immunology,2003,3(4):292-303.  

[29] ROUND J L,MAZMANIAN S K.The gut microbiota shapes intestinal immune responses during health and disease[J].Nature Reviews Immunology,2009,9(5):313-323.  

[30] RENZ H,BRANDTZAEG P,HORNEF M.The impact of perinatal immune development on mucosal homeostasis and chronic inflammation[J].Nature Reviews Immunology,2012,12(1):9-23.

[31] MAYNARD C L,ELSON C O,HATTON R D,et al.Reciprocal interactions of the intestinal microbiota and immune system[J].Nature,2012,489(7415):231-241.  

[32] HAMADA H,HIROI T,NISHIYAMA Y,et al.Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine[J].The Journal of Immunology,2002,168(1):57-64.  

[33] BOUSKRA D,BRÉZILLON C,BÉRARD M,et al.Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis[J].Nature,2008,456:507-510.

[34] BUTLER J E,LAGER K M,SPLICHAL I,et al.The piglet as a model for B cell and immune system development[J].Veterinary Immunology and Immunopathology,2009,128(1/2/3):147-170.

[35] LAYCOCK G,SAIT L,INMAN C,et al.A defined intestinal colonization microbiota for gnotobiotic pigs[J].Veterinary Immunology and Immunopathology,2012,149(3/4):216-224.

[36] O'Neill L A J,GOLENBOCK D,BOWIE A G.The history of Toll-like receptors-redefining innate immunity[J].Nature Reviews Immunology,2013,13(6):453-460.  

[37] STEINMAN L.A brief history of TH17,the first major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage[J].Nature Medicine,2007,13(2):139-145.  

[38] JOLLER N,LOZANO E,BURKETT P R,et al.Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses[J].Immunity,2014,40(4):569-581.  

[39] GABORIAU-ROUTHIAU V,RAKOTOBE S,LÈCUYER E,et al.The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses[J].Immunity,2009,31(4):677-689.  

[40] IVANOV I I,ATARASHI K,MANEL N,et al.Induction of intestinal Th17 cells by segmented filamentous bacteria[J].Cell,2009,139(3):485-498.  

[41] ATARASHI K,TANOUE T,SHIMA T,et al.Induction of colonic regulatory T cells by indigenous Clostridium species[J].Science,2011,331(6015):337-341.  

[42] NICHOLSON J K,HOLMES E,KINROSS J,et al.Host-gut microbiota metabolic interactions[J].Science,2012,336(6086):1262-1267.  

[43] ARPAIA N,CAMPBELL C,FAN X Y,et al.Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation[J].Nature,2013,504(7480):451-455.  

[44] FURUSAWA Y,OBATA Y,FUKUDA S,et al.Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells[J].Nature,2013,504(7480):446-450.  

[45] MASLOWSKI K M,VIEIRA A T,NG A,et al.Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43[J].Nature,2009,461(7268):1282-1286.  

[46] INAN M S,RASOULPOUR R J,YIN L,et al.The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line[J].Gastroenterology,2000,118(4):724-734.  

[47] VAVASSORI P,MENCARELLI A,RENGA B,et al.The bile acid receptor FXR is a modulator of intestinal innate immunity[J].The Journal of Immunology,2009,183(10):6251-6261.  

[48] MYSZKA M,KLINGER M.The immunomodulatory role of vitamin D[J].Postepy higieny imedycyny doswiadczalnej(Online),2014,68:865-878.

[49] REYES-BECERRIL M,ASCENCIO-VALLE F,TOVAR-RAMÍREZ D,et al.Effects of polyamines on cellular innate immune response and the expression of immune-relevant genes in gilthead seabream leucocytes[J].Fish Shellfish Immunology,2011,30(1):248-254.  

[50] FENG T,WANG L F,SCHOEB T R,et al.Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis[J].The Journal of Experimental Medicine,2010,207(6):1321-1332.  

[51] DRAPER E,DECOURCEY J,HIGGINS S C,et al.Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses[J].The Journal of Nutritional Biochemistry,2014,25(7):741-749.  
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