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Immunomodulatory Effects of Glycine and Its Molecular Mechanism

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  • 1. Animal Nutrition Institute, Agriculture and Animal Husbandry Academy of Inner Mongolia, Hohhot 010031, China;
    2. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2014-10-31

  Online published: 2015-03-18

Abstract

Glycine is a simple, non-essential amino acid, participates in the synthesis of protein and many physiologically important molecules, and it has been well characterized as an inhibitory neurotransmitter in the central nervous system. Except for the protection of glycine in experimental models of ischaemia-reperfusion injury, shock, transplantation, alcoholic hepatitis, hepatic fibrosis, arthritis, tumour and drug toxicity, ample evidence has been generated demonstrating that glycine has anti-inflammatory and immunomodulatory function, but the exact mechanism(s) responsible for the protective and anti-inflammatory action of glycine are still unclear. This paper reviewed the basic characteristics, the physiological protective fuctions, anti-inflammatory and immunomodulatory effects and possible molecular mechanisms of glycine, discussed the modulation possibility of glycine on mastitis control of lactating ruminants, and provided promising insights into the development of glycine as a natural immunomodulatory agent in practice.

Cite this article

DU Ruiping, ZHANG Xingfu, GAO Min, AO Changjin . Immunomodulatory Effects of Glycine and Its Molecular Mechanism[J]. Chinese Journal of Animal Nutrition, 2015 , 27(3) : 663 -670 . DOI: 10.3969/j.issn.1006-267x.2015.03.001

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